Drug Solubility Services
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Manufactured by CD Formulationbased in USA
CD Formulation provides a complete set of services for the development and manufacturing of improved drug solubility and bioavailability, including the provision of pH regulators, drug solubility evaluation, etc. We have quality systems, infrastructure, and capabilities to create a low-risk path for commercial production even ...
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Manufactured by CD Formulationbased in USA
Method Development & Method Validation for Solubility and Dissolution Curves: Accurate determination of the aqueous solubility of drugs is very important for understanding quality control and drug delivery issues of pharmaceutical formulations, and is influenced by the physicochemical properties of the drug, the ...
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Manufactured by CD Formulationbased in USA
Industry estimates indicate that over 80% of new chemical entities exhibit low solubility, low bioavailability, and/or low or inconsistent dissolution rates. Effectively addressing these drug solubility, bioavailability, and dissolution rate issues is critical to advancing compound development and providing patients with the therapeutic ...
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Manufactured by CD Formulationbased in USA
Industry estimates indicate that over 80% of new chemical entities exhibit low solubility, low bioavailability, and/or low or inconsistent dissolution rates. Effectively addressing these drug solubility, bioavailability, and dissolution rate issues is critical to advancing compound development and providing patients with the therapeutic ...
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Manufactured by CD Formulationbased in USA
About 40% of newly developed medicinal chemical entities have poor water solubility, and 90% of drugs under development can be classified as poorly soluble drugs. A solid dispersion (SD) refers to a dispersion system in which the drug particle size is within the range of 0.001 to 0.1 μm in a certain state and ...
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Manufactured by CD Formulationbased in USA
Bioavailability refers to the degree and speed at which a drug is absorbed into the blood circulation. There are ongoing challenges with poorly water-soluble drugs and have failed to reach the market due to their poor water solubility. CD Formulation has developed a range of technologies and formulation expertise to improve the ...
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Manufactured by CD Formulationbased in USA
that achieves programmable homogeneous particle size, improved encapsulation of water-soluble drugs, and reduced handling procedures that can achieve controlled or sustained release of ...
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based in USA
Pace® offers small scale feasibility and current Good Manufacturing Practices (cGMP) pilot scale processes for bioavailability enhancement of orally administered small molecules. Leverage our commercially proven approaches to boosting bioavailability for poorly water-soluble drugs through production of amorphous solid ...
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Manufactured by CD Formulationbased in USA
At present, many drugs are often lower than the concentration required for treatment due to their low solubility, even in saturated solutions. For example, the solubility of chloramphenicol in water is 0.25%, and clinically, more than 12.5% solution is required for intramuscular or intravenous injection. In the pharmaceutical liquid ...
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Manufactured by Ascendia Pharmaceuticalsbased in USA
Ascendia specializes in the development of market suitable formulations for poorly water soluble drug substances. Based on the pre-formulation data package and the delivery requirements for the product, we recommend a comprehensive formulation development strategy. We understand that each formulation is unique and must address the ...
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Manufactured by CD Formulationbased in USA
CD Formulation's self-emulsifying drug delivery system service can evaluate the bioavailability of drugs and suggest suitable product solutions. Our professional team has the ability to establish and validate analytical methods, determine oil/water partition coefficients, investigate the equilibrium solubility of drugs in water, ...
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Manufactured by Ascendia Pharmaceuticalsbased in USA
for Phase I studies. At Ascendia, our core business is to develop practical, customized product formulations for poorly water soluble drugs. We offer rapid and cost-effective formulation technology screening services through the utilization of our multiple nano-particle technology ...
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Manufactured by Ascendia Pharmaceuticalsbased in USA
Ascendia develops and evaluates a variety of formulations for preclinical non-GLP and GLP studies. We understand the needs of companies with an exciting compound in the discovery pipeline, but with limited amounts of drug substance. We have developed methods for carrying out formulation screening studies with as little as several mg of ...
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Manufactured by Ascendia Pharmaceuticalsbased in USA
Nanotechnology is now being extensively utilized in the development of innovative drug delivery systems for various routes of administration. Due to the advantages of their targeted drug delivery, reduced toxicity, long circulation, and enhanced half-life, nanoparticles are particularly useful for use in long acting ...
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Manufactured by CD Formulationbased in USA
Bioavailability depends on several factors. The solubility of the drug in an aqueous environment and the permeability of the drug through the lipophilic membrane are important factors. The pH adjustment method is a technique that increases the solubility of ionizable API by adding acidic and alkaline excipients to the ...
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Manufactured by Creative Bioarraybased in USA
Creative Bioarray provides various in vitro ADME/PK services including high-throughput ADME screening, in vitro metabolism, in vitro permeability and transporter assays. ADME is short for "absorption, distribution, metabolism, and excretion". The four properties determine the drug level within a body, the drug exposure to ...
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Manufactured by Ascendia Pharmaceuticalsbased in USA
Parenteral formulation development for drugs delivered by injection or infusion is the fastest and the second most common route of drug administration. These formulations must achieve good compatibility of the drug substances with the excipients and the primary container. ...
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Manufactured by Ascendia Pharmaceuticalsbased in USA
Parenteral formulation development for drugs delivered by injection or infusion is the fastest and the second most common route of drug administration. These formulations must achieve good compatibility of the drug substances with the excipients and the primary container. Successful formulation development can determine drug ...
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