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Pharmacokinetic Modeling Physiology Based Pharmacokinetic Services
41 services found
by:Center for Toxicology and Environmental Health, L.L.C. (CTEH) based inNorth Little Rock, ARKANSAS (USA)
CTEH® provides both traditional pharmacokinetic modeling and physiologically-based pharmacokinetic (PBPK) modeling. CTEH® toxicologists are experienced in developing and applying traditional and PBPK modeling to reconstruct exposure and dose, support the establishment of ...
Manufactured by:Creative Biolabs based inShirley, NEW YORK (USA)
Pharmacokinetics (PK) models are generated to elucidate the transformations that a drug undergoes in an organism and the rules that determine this ...
Manufactured by:Bexson Biomedical based inSanta Barbara, CALIFORNIA (USA)
We are developing a formulation technology platform & a subcutaneous delivery platform for controlled delivery of critical medications in need of pharmacokinetic ...
Manufactured by:Creative Biolabs based inShirley, NEW YORK (USA)
Creative Biolabs developed a constrained peptide library construction technology, which offers constrained peptides with target-adapted cross-links. Our technology involves generating natural or semi-synthetic peptides with constrained structures to retain and improve the properties (e.g. stability, resistance to protease activity, protein binding affinity, intrinsic cell permeability, etc.) of ...
Manufactured by:Alfa Chemistry based inNY, NEW YORK (USA)
Lead optimization is a complex and iterative process for identifying an improved drug lead with the goal of progressing to a preclinical candidate by altering the chemical structure of a confirmed hit. A diversity of properties such as target’s specificity, selectivity, pharmacodynamics, pharmacokinetics and toxicological properties are improved by modifying the chemical structures of compounds ...
Manufactured by:Creative Biolabs based inShirley, NEW YORK (USA)
ADMET stands as an abbreviation for absorption, distribution, metabolism, excretion, and toxicity in pharmacokinetics and pharmacology. These properties describe the reaction of a drug medication within an organism, human, or animal, which helps scientists evaluate their drug candidates and select compounds that are likely to have the desired effects on patients. ...
Manufactured by:Creative Biolabs based inShirley, NEW YORK (USA)
Pharmacokinetics (PK) studies provide critical information regarding the behavior of a drug in circulation and its ultimate form after extensive in vivo metabolism. Results from PK studies often serve as guidelines for clinical trials designs, especially in the development of an antibody-drug conjugate (ADC). Due to the heterogeneous nature of ADCs, multiple analytes have to be assessed to reveal ...
Manufactured by:Creative Biolabs based inShirley, NEW YORK (USA)
Pharmacokinetics (PK) studies provide critical information regarding the behavior of a drug in circulation and its ultimate form after extensive in vivo metabolism. Results from PK studies often serve as guidelines for clinical trials designs, especially in the development of an antibody-drug conjugate (ADC). Due to the heterogeneous nature of ADCs, multiple analytes have to be assessed to reveal ...
Manufactured by:Creative Biolabs based inShirley, NEW YORK (USA)
Pharmacology and pharmacodynamics studies are of great importance in determining a drug's effect during drug discovery and development. A large variety of animal models has been developed to provide investigators with the ability to characterize the pharmacokinetics and pharmacodynamics of ...
Manufactured by:Creative Biolabs based inShirley, NEW YORK (USA)
Small molecule inhibitors are a class of small molecules that interact with proteins and reduce the biological activity of target proteins. The structure of small molecule inhibitors has good spatial dispersion, and their chemical properties determine their good pharmacodinemic properties and pharmacokinetic properties. These characteristics make small molecule inhibitors show great advantages in ...
Manufactured by:Alfa Chemistry based inNY, NEW YORK (USA)
Early studies on the properties of drugs in ADMET mainly focused on human-derived or humanized tissue functional proteins as drug targets. Combined with in vitro research techniques and computer simulation, scientists study the interaction between drugs and in vivo biophysical and biochemical barrier factors. Alfa Chemistry can predict ADME parameters and pharmacokinetic properties by calculating ...
Manufactured by:CD Formulation based in, NEW YORK (USA)
CD Formulation researchers have conducted extensive research and development of drug delivery systems (DDS) in order to improve the pharmacokinetics and pharmacodynamics of drugs by delivering the required dose at the target site at the appropriate time and rate. Our drug delivery system development offerings include nanoparticles and particles, transdermal patches, and more. Our current services ...
Manufactured by:CD Formulation based in, NEW YORK (USA)
Solubility and bioavailability issues run through drug metabolism and pharmacokinetic evaluation of candidate compounds, preclinical prescription development, and commercial formulation development. From the toxicological evaluation stage, CD Formulation has a perfect drug metabolism and pharmacokinetic support system, each experiment only consumes milligram-level API, which can help customers ...
Manufactured by:Creative Biolabs based inShirley, NEW YORK (USA)
Pharmacokinetics (PK) dedicated to determining the mechanisms of a drug's absorption, biodistribution, when it eliminated from the body and what it becomes. It is a study of how an organism affects a drug. In vivo PK studies are critical to ensure drug candidates have appropriate PK properties that can be evaluated in preclinical pharmacology and safety studies. In vivo PK studies provide ...
Manufactured by:Invicro, LLC based inNeedham, MASSACHUSETTS (USA)
Invicro has a vast range of tools that help accelerate your drug discovery and development process. Our technology platforms support key decision-making in: Early discovery and screening. Candidate selection. First-in-human translation and early development. Late stage, multi-center determination of ...
Manufactured by:ACROBiosystems based inNewark, DELAWARE (USA)
Anti-idiotypic antibodies are antibodies that target the variable region of another antibody to produce specific binding. These antibodies are widely used in drug development: they can be used as an important reference standard for immunogenicity analysis or can be developed to specifically detect antibody drug levels for pharmacokinetic studies. ACROBiosystems is committed to providing high ...
by:Eurofins bioskin ( formely Bioskin GmbH) based inHamburg, GERMANY
Investigation of cutaneous safety is a critical component of product development for topical and systemic products and transdermal systems. At bioskin we are experienced in the design and conduct of the entire spectra of cutaneous safety studies and offer a battery of safety tests required for assessment of products which are applied locally. In addition we plan and conduct studies evaluating ...
Manufactured by:Alfa Chemistry based inNY, NEW YORK (USA)
One of the most important steps in the process of developing a medicine is determining its safety. Alfa Chemistry is dedicated to providing pre-clinical drug research services to support our clients' drug development, pre-clinical and clinical investigations, and assist them in deciding which drug candidates are most worthwhile to pursue in clinical trials. We emphasize pharmacology, ...
by:Center for Toxicology and Environmental Health, L.L.C. (CTEH) based inNorth Little Rock, ARKANSAS (USA)
CTEH®’s pharmacology & toxicology professionals have extensive experience assessing the human toxicity of drugs and chemicals, and drug interactions and adverse reactions. CTEH® provides additional experience in pharmacokinetic analysis. Levels of drugs or chemicals in blood and/or urine are frequently key pieces of information in accidents, worker exposure issues, and in ...
Manufactured by:Atriva Therapeutics GmbH based inTübingen, GERMANY
The company’s lead drug candidate is the MEK inhibitor zapnometinib. The small molecule, which can be administered orally (tablet), is under advanced clinical development in two severe respiratory viral diseases: COVID-19 and influenza, two disease areas with urgent need for effective ...