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Phenotyping Services
46 services found
by:Rady Children`s Institute for Genomic Medicine based inSan Diego, CALIFORNIA (USA)
We provide a quick turnaround, offering actionable results to guide Rapid Precision Medicine™ and improve patient outcomes. Phenotype-Driven Results: Rapid, robust phenotype-driven results are delivered to inform medical management. Actionable Next Steps: We expedite disease-specific molecular diagnoses in time to make a clinical difference. Expert ...
by:OracleBio based inGlasgow, UNITED KINGDOM
Adding value to Immuno-Oncology studies with Quantitative Digital Pathology. Quantitative Digital Pathology provides deep insights into the tumor microenvironment (TME), a knowledge which is crucial for understanding the mechanism of action of new oncology immunotherapies or for investigating new biomarkers. ...
Manufactured by:Creative Biogene-Mitochondrial Research based inNY, NEW YORK (USA)
Mitochondrial dysfunction is rapidly developing as a key pathological feature of early and persistent lung disease. In particular, mitochondria are emerging as central to the pathological processes and clinical phenotypes associated with a range of lung diseases. Creative Biogene provides a comprehensive range of services and products to assist researchers in lung-disease-related ...
Manufactured by:Creative Bioarray based inShirley, NEW YORK (USA)
Creative Bioarray has developed human highly immortalized differentiated cell lines from various human tissues that show stable growth characteristics and phenotypes and have a high potential for production of complex biopharmaceuticals such as recombinant proteins, vaccines or extracellular vesicles. Creative Bioarray provides already established cell lines to get ...
by:Science in Action based inNess Ziona, ISRAEL
In vitro migration and invasion assays provide a simple and fast quantitative platform to measure cellular migratory or invasive phenotypes, in vitro. In this assay, cells are allowed to migrate through an artificial membrane towards a chemo-attractant gradient. The efficiency of this process is assessed by fluorometric analysis. Migration through a membrane coated with basement ...
Manufactured by:Creative Biogene based inShirley, NEW YORK (USA)
Model plant is a species that has been widely studied. With its characteristics like dwarf phenotype, short life cycle, fertility and small genome, model plant plays a crucial role in plant genomics research. Model plant is highly homologous with other complex plants in molecular level. Therefore, genome research of model plant establishes a foundation to reveal the functional ...
Manufactured by:CN Bio based inCambridge, UNITED KINGDOM
Our Non-Alcoholic Fatty Liver Disorder (NAFLD)/NASH in vitro Services offer a preclinical tool to test therapeutics in a human-relevant model, replicating key disease phenotypes including fibrosis and reporting clinical biomarkers to allow translatability to clinical trials. ...
Manufactured by:vivoVerse Inc. based inAustin, TEXAS (USA)
The vivoChip® enables the use of C. elegans for high-content, multi-parametric analysis of neurodegeneration phenotypes from high-resolution fluorescence images of neurons. To demonstrate our unique capabilities, we studied dendritic neurodegeneration of dopaminergic neurons in C. elegans induced by a well-accepted neurotoxicant, MPP+, showing dose-dependent increase in ...
Manufactured by:Curi Bio based inSeattle, WASHINGTON (USA)
Curi Bio has a repository of iPSC’s for disease modeling and proprietary technologies for differentiating these cells into myoblasts and cardiomyocytes. Curi has developed in vitro 3D disease models for multiple disease phenotypes. In addition, Curi has the capability of generating new gene-edited iPSC models in ...
by:InVivo Biosystems based inEugene, OREGON (USA)
They allow researchers to study the effects of the absence of a particular gene, protein segment, amino acid, or regulatory element, thereby enabling the researcher to determine their function. Gene knockouts are a commonly used tool for biologists to understand gene function. Examination of phenotypes when the gene is deleted can reveal insights into what role that gene plays in ...
Manufactured by:Creative Bioarray based inShirley, NEW YORK (USA)
Immortalized cell lines and services are of ever-increasing importance in various aspects of biomedicine, toxicology and biotechnology. The cells can be used as model systems in phenotypic and drug screening, high content analysis, target identification, drug development, toxicology testing, gene editing studies, reporter assays. Besides, the immortalized cells have implications ...
Manufactured by:Creative Bioarray based inShirley, NEW YORK (USA)
Immortalized cell lines and services are of ever-increasing importance in various aspects of biomedicine, toxicology and biotechnology. The cells can be used as model systems in phenotypic and drug screening, high content analysis, target identification, drug development, toxicology testing, gene editing studies, reporter assays. Besides, the immortalized cells have implications ...
by:Strateos Inc. based inMenlo Park, CALIFORNIA (USA)
Our state-of-the-art fully automated robotic platform is set-up to accelerate your drug discovery process starting with robust, targeted hit identification services. Our system can efficiently run biochemical, phenotypic and cellular HTS assays in 384- or 1536-well ...
by:Champions Oncology, Inc. based inHackensack, NEW JERSEY (USA)
Champions Oncology has a team of highly qualified PhD flow cytometrists with the expertise in oncology modeling as well as phenotypic analysis to ensure your data is reliable and scientifically relevant to your clinical trial. We work with you to define reportables for each flow cytometry panel that was developed and validated and ensure the data is reported in a format that ...
Manufactured by:Ozgene Pty Ltd. based inBentley DC, AUSTRALIA
These mouse models allow researchers to gain insight into how the loss of the gene affects physiology, behavior and disease development. Observing the characteristics of a knockout phenotype can also help researchers understand human gene expression and genetic ...
Manufactured by:RoosterBio, Inc. based inFrederick, MARYLAND (USA)
As a raw material in emerging cell, gene, and exosome based therapies, understanding the key quality attributes of your hMSC, such as phenotype, function, and growth kinetics are vital to understanding expansion and therapeutic potential. At RoosterBio Inc., we have years of experience in hMSC isolation, manufacturing, and characterization. Leverage this expertise within your ...
Manufactured by:Newcells Biotech Limited based inNewcastle Upon Tyne, UNITED KINGDOM
Activated fibroblasts differentiate into myofibroblasts, a process known as fibroblast-to-myofibroblast transition (FMT). This persistent myofibroblast phenotype leads to an increased synthesis of extracellular matrix proteins, and their deposition within the lung parenchyma, causing progressive scarring, increased lung stiffness and a loss in lung function. ...
Manufactured by:Newcells Biotech Limited based inNewcastle Upon Tyne, UNITED KINGDOM
Both models are iPSC derived allowing gene-edited lines to be engineered using CRISPR/Cas9 for direct comparison between WT and mutant phenotypes after differentiation. Targeted mutations can model retinopathies, more specifically monogenic inherited retinopathies such as retinitis pigmentosa (RP), Stargardt disease, Usher’s syndrome and Leber congenital ...
Manufactured by:ProImmune Ltd. based inOxford, UNITED KINGDOM
Blood collection, shipping and processing is often the first point of failure for cell based immunology assays, such as ELISpot, flow cytometric phenotyping and functional cell based assays. When these assays are planned as part of multi-center clinical trials, setting up processes for collecting processing, shipping, preserving blood incorrectly can have catastrophic ...
by:MtoZ Biolabs based in, MASSACHUSETTS (USA)
After a target is identified, it must be validated to demonstrate the functional relationship between the target and disease phenotype while ensuring safety. The drug discovery process is lengthy and costly, but good target validation increases the likelihood of developing effective drugs and achieving clinical success. ...