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Mtoz Biolabs Protein Targeting Services
24 services found
by:MtoZ Biolabs based in, MASSACHUSETTS (USA)
Many drugs target proteins that function as receptors for small-molecule ligands. These ligands bind to and alter the structures of their protein targets, thus modulating their biological activities. Key protein targets in the fields of biology and pharmaceutical research include the nuclear ...
by:MtoZ Biolabs based in, MASSACHUSETTS (USA)
Small molecules predominantly modulate the activity of their protein targets. The majority of approved small molecule inhibitors target intracellular kinases, which regulate cell signaling by transferring phosphate groups to target proteins. Contemporary research extensively focuses on targets ...
by:MtoZ Biolabs based in, MASSACHUSETTS (USA)
Far-western blot is a molecular biology method based on western blot technology that can be used to detect protein-protein interactions in vitro, especially interactions that do not require the natural structure of the target ...
by:MtoZ Biolabs based in, MASSACHUSETTS (USA)
Diacylglycerol (DAG), also known as diglyceride, consists of two fatty acid chains and a glycerol molecule. It primarily exists in two forms: 1,2-diacylglycerol and 1,3-diacylglycerol. DAG can be synthesized via the phosphatidic acid pathway in the endoplasmic reticulum by the action of phosphatidic acid phosphatase or produced during the lipolysis of triglycerides (TAG) by TAG lipase. DAG is ...
by:MtoZ Biolabs based in, MASSACHUSETTS (USA)
During the production of bioproducts, it's common to find impurities not only produced in the manufacturing process but also related to the desired products. These product-related impurities typically consist of product variants that do not align functionally with the target product. The most common variants arise from chemical modifications, as well as from the degradation and ...
by:MtoZ Biolabs based in, MASSACHUSETTS (USA)
Molecular size variation critically influences the properties of biomacromolecules such as proteins, antibodies, and peptides, especially in the realms of drug research and bioproduct manufacturing. Size Exclusion Chromatography (SEC), also known as Gel Permeation Chromatography (GPC), separates compounds based on molecular size. ...
by:MtoZ Biolabs based in, MASSACHUSETTS (USA)
In the biological activities of organisms, the function of proteins is achieved through interactions between proteins. Therefore, studying new protein interactions can provide new directions for investigating the potential functions of proteins. Among many protein interaction identification experiments, pull-down is commonly used for in vitro protein interaction testing, and helps discover new ...
by:MtoZ Biolabs based in, MASSACHUSETTS (USA)
Proteolysis targeting chimera (PROTAC) drugs offer a novel approach to disease treatment by leveraging the body's innate protein degradation pathways. In contrast to traditional small-molecule inhibitors, PROTAC drugs promote the degradation of specific proteins rather than directly inhibiting their function, thus mitigating or eliminating their ...
by:MtoZ Biolabs based in, MASSACHUSETTS (USA)
Antibodies bind to various antigens with high affinity and specificity, playing a crucial role in adaptive immune response to infections and can also mediate autoimmune diseases by targeting self-antigens. Antibodies facilitate immunity by inhibiting critical stages of a pathogen's replication cycle, such as receptor binding and cellular entry, activating the complement system, or initiating ...
by:MtoZ Biolabs based in, MASSACHUSETTS (USA)
A key step in drug discovery is target identification—identifying "druggable" biological targets. After a target is identified, it must be validated to demonstrate the functional relationship between the target and disease phenotype while ensuring safety. The drug discovery process is lengthy and costly, but good target validation increases the likelihood of developing effective drugs and ...
by:MtoZ Biolabs based in, MASSACHUSETTS (USA)
Proteins play a pivotal role in the regulation, function, and structure of various human organs and tissues. The regulation of the synthesis and degradation of proteins is crucial for cell functionality. Protein turnover can exist in three states: equilibrium, pool expansion, and pool contraction. At equilibrium, the rate of protein synthesis matches that of degradation, leading to unchanged ...
by:MtoZ Biolabs based in, MASSACHUSETTS (USA)
The CUT&Tag analysis service utilizes cleavage and transposase tagging technology to precisely map the binding sites of transcription factors or histone modifications within the genome, facilitating research into DNA-protein interaction mechanisms. It provides an accurate solution for genomic and epigenetic studies. MtoZ Biolabs provides the CUT&Tag analysis service leveraging an advanced ...
by:MtoZ Biolabs based in, MASSACHUSETTS (USA)
With the increasing focus on personalized healthcare, there is a growing demand for biomarkers for early diagnosis, prognosis, patient stratification, or monitoring treatment response. Compared with genetic biomarkers, protein biomarkers provide higher degrees of differential information. Olink proteomics is based on a unique proximity extension assay (PEA) technique that enables simultaneous ...
by:MtoZ Biolabs based in, MASSACHUSETTS (USA)
PROTACs represent a novel strategy for protein degradation that has gained prominence recently. Utilizing bifunctional molecules, PROTACs enable the targeted ubiquitination and subsequent degradation of proteins via the UPS. PROTACs can not only offer potential therapeutic applications for a variety of conditions, including cancer, immune ...
by:MtoZ Biolabs based in, MASSACHUSETTS (USA)
Antibody therapies leverage human immune system antibodies to treat diseases by targeting specific proteins on pathogens or abnormal cells with exceptional precision. The development of antibody therapies has evolved from early polyclonal sera to monoclonal antibodies, and now to genetically engineered antibodies, focusing on enhancing drug safety, effectiveness, ...
by:MtoZ Biolabs based in, MASSACHUSETTS (USA)
Protein-based macromolecular drugs, typically organic compounds with molecular weights exceeding 1000, depend on cellular biosynthesis and are also known as biologics. Compared to traditional small molecule drugs, protein drugs are characterized by their high potency, strong specificity, low toxicity, clear biological function, and conducive to clinical application. Protein drugs are the ...
by:MtoZ Biolabs based in, MASSACHUSETTS (USA)
Activity-based protein profiling (ABPP) is a versatile and powerful chemoproteomic technique, utilizing activity-based probes (ABPs) that selectively and covalently interact with the active sites of proteins. This approach allows for the capture and analysis of tagged proteins using various proteomic tools. ABPP facilitates the global and quantitative examination of protein functional states in ...
by:MtoZ Biolabs based in, MASSACHUSETTS (USA)
The process where proteins separated by electrophoresis are transferred or “blotted” from the gel matrix onto a membrane (usually nitrocellulose or polyvinylidene difluoride (PVDF)), followed by subsequent antibody-based detection on the membrane surface, is known as western blot (WB) or immunoblotting. Mtoz Biolabs provides WB analysis ...
by:MtoZ Biolabs based in, MASSACHUSETTS (USA)
Drug screening refers to the evaluated process of substances (samples) potentially used as drugs, assessing their biological activity, pharmacological effects, and therapeutic value through appropriate methods. This process encompasses biochemical and cellular levels of screening, divided into high-throughput screening (HTS) and virtual ...
by:MtoZ Biolabs based in, MASSACHUSETTS (USA)
Ion channels are made up of special proteins produced by cells, which are aggregated and embedded in the cell membrane, forming pores occupied by water molecules. These pores are the channels for water-soluble substances, which can quickly enter and exit the ...