Target Protein Services
45 services found
by:MtoZ Biolabs based in, MASSACHUSETTS (USA)
With the rapid development of biotechnology, drug research and development has gradually entered a new era of precision and personalization. Targeted Protein Degradation (TPD) drugs are an emerging therapeutic strategy that utilizes the body's ubiquitin-proteasome system to degrade specific pathological proteins to achieve precise treatment. As ...
by:MtoZ Biolabs based in, MASSACHUSETTS (USA)
In the biological activities of organisms, the function of proteins is achieved through interactions between proteins. Therefore, studying new protein interactions can provide new directions for investigating the potential functions of proteins. Among many protein interaction identification experiments, pull-down is commonly used for in vitro protein interaction testing, and helps discover new ...
by:MtoZ Biolabs based in, MASSACHUSETTS (USA)
Proteolysis targeting chimera (PROTAC) drugs offer a novel approach to disease treatment by leveraging the body's innate protein degradation pathways. In contrast to traditional small-molecule inhibitors, PROTAC drugs promote the degradation of specific proteins rather than directly inhibiting their function, thus mitigating or eliminating their ...
by:MtoZ Biolabs based in, MASSACHUSETTS (USA)
Proteins play a pivotal role in the regulation, function, and structure of various human organs and tissues. The regulation of the synthesis and degradation of proteins is crucial for cell functionality. Protein turnover can exist in three states: equilibrium, pool expansion, and pool contraction. At equilibrium, the rate of protein synthesis matches that of degradation, leading to unchanged ...
by:MtoZ Biolabs based in, MASSACHUSETTS (USA)
PROTACs represent a novel strategy for protein degradation that has gained prominence recently. Utilizing bifunctional molecules, PROTACs enable the targeted ubiquitination and subsequent degradation of proteins via the UPS. PROTACs can not only offer potential therapeutic applications for a variety of conditions, including cancer, immune ...
Manufactured by:Orbit Discovery based inOxford, UNITED KINGDOM
Engineering soluble and membrane bound proteins. Our flexible peptide display platforms allow for screening directly against both cells and recombinant target protein. The Orbit team incudes experts on structural biology and protein production to ensure the quality of target protein for affinity ...
by:Ainnocence Inc. based inSacramento, CALIFORNIA (USA)
Concentrated; PharmCollectibles contains a highly selective chemical probe library for over 2,000 human target protein for efficient target identification. Representative; PharmaCollectibles condenses 14 million chemical compounds into a 50,000 compound library against a highly diverse set of ...
Manufactured by:Creative Biolabs based inShirley, NEW YORK (USA)
The drug-discovery process is a trial-and-error run and time-consuming. Currently, using in silico tools to find a molecule that binds to the target protein has made computational chemistry a valuable tool in drug ...
Manufactured by:Inovotion Sas based inLa Tronche, FRANCE
Target validation is an essential and critical phase of the drug discovery process. This is a crucial step before starting to develop a treatment based on a targeted protein that has been identified to play a role in the disease. The target protein’s role must be clearly identified before starting to ...
by:Creative Proteomics based inNew York, NEW YORK (USA)
Ubiquitin is an about 8.5 kDa polypeptide consisting of 76 amino acids that is appended to the ε-NH2 of lysine in target proteins via the C-terminal glycine of ubiquitin. Following an initial monoubiquitination event, the formation of a ubiquitin polymer may occur, and polyubiquitinated proteins are then recognized by the 26S proteasome ...
Manufactured by:Creative Biolabs based inShirley, NEW YORK (USA)
Small molecule inhibitors are a class of small molecules that interact with proteins and reduce the biological activity of target proteins. The structure of small molecule inhibitors has good spatial dispersion, and their chemical properties determine their good pharmacodinemic properties and pharmacokinetic properties. ...
Manufactured by:Orbit Discovery based inOxford, UNITED KINGDOM
The result is a library of unique beads each displaying thousands of copies of peptide, providing massive chemical diversity and the ability to perform rapid screens for high affinity binders against soluble or more complex target proteins, such as GPCRs and ion ...
Manufactured by:Genscript based inPiscataway, NEW JERSEY (USA)
Our BacPower™ Guaranteed Bacterial Recombinant Protein Expression Service offer a comprehensive panel of options for your target protein production in an E. coli system with guaranteed protein amounts, purities as well as endotoxin levels to meet a variety of your research needs, especially for protein ...
by:MtoZ Biolabs based in, MASSACHUSETTS (USA)
Far-western blot is a molecular biology method based on western blot technology that can be used to detect protein-protein interactions in vitro, especially interactions that do not require the natural structure of the target ...
by:MtoZ Biolabs based in, MASSACHUSETTS (USA)
Small molecules predominantly modulate the activity of their protein targets. The majority of approved small molecule inhibitors target intracellular kinases, which regulate cell signaling by transferring phosphate groups to target proteins. Contemporary research extensively focuses on targets ...
by:Base Pair Biotechnologies, Inc. based inPearland, TEXAS (USA)
Receive one vial of Aptamer Resuspension Buffer and one vial of Aptamer Folding Buffer FREE with any Catalog Aptamer Purchase*. Base Pair offers catalog aptamers to a diverse range of target molecules, including proteins, antibodies, small molecules, toxins, bacterial proteins, cytokines, and more. Aptamers can be purchased with a wide range of ...
by:Reaction Biology Corp. based inMalvern, PENNSYLVANIA (USA)
Cell-based assays are valuable to probe new drug candidates in the environment of intact cells with physiologic concentrations of substrates, co-factors and ...
by:RASA Life Science Informatics based inPune, INDIA
How Our Protein Modelling Service / Homology modeling Service Can Help You? Rasa Bioinformatic CRO Lab offer high quality protein tertiary structures custom modeling services based on your own amino-acid sequences. Combination of modeling and short term simulations under controlled parameters will ensure the reliability of modeled structure for further studies RASA’s protein modeling ...
Manufactured by:Echelon Biosciences, Inc (EBI) based inSalt Lake City, UTAH (USA)
Nanobodies are single domain antibodies produced from camelids by immunization with a target antigen, similar to the process used in mice and rabbits for traditional antibody generation. However, because of the single heavy chain found in camelid antibodies, cDNAs can be generated from this single domain which can then be expressed recombinantly. This opens up a wide variety of applications that ...
Manufactured by:Preclinics GmbH based inPotsdam, GERMANY
Their heavy-chain antibodies lack the light chain and therefore can be used to develop recombinant single-domain antibodies (VHH fragments) with several benefits: Small size: With a molecular weight of approximately 15 kDa, Easier production, High stability: As there is only one protein chain, correct refolding after physical stress keeps the functionality.We can immunize your ...