Locus - Product Development Services
From Locus Manufacturing
We built a world-class biologics manufacturing facility, enabling the manufacture of our precision therapeutics while providing the capability to also manufacture gene therapy vectors and other advanced biologics. Our facility design allows for parallel production of multiple drug substances simultaneously, in isolated production suites, without risk of cross-contamination. It is optimized for viral vector manufacturing, including bacteriophage, adenovirus, AAV, and other vectors. Taken together, our facility and proprietary production processes allow for all viral products manufactured by Locus to meet or exceed US and international regulatory standards for parenterally administered drug products for clinical and commercial use.
Our advanced biologics manufacturing facility was designed to provide the company with the ability to optimize viral vector production end-to-end.
The site supports upstream and downstream development focused on amplification titer optimization and removal of impurities through a serious of DOEs studying various excipients and concentrations across surfactants and buffers. In addition to the facility, there are processes in place for phage and bacteria bank production and release, as well as processes to maximize viral titer amplification while removing host cell protein and endotoxin.