CD Formulation -Melatonin Microneedle Patch Preparation
FromCD Formulation
Advantages of Melatonin Microneedle Patch Preparation
The polymeric material PVA is widely used in pharmacy and has good skin compatibility. aqueous PVA solution can be solidified into a gel after freeze-thaw cycles, the more cycles, the higher the cross-linking of the gel.
In order to separate the microneedle from the mold better, the backing layer is prepared with the same polymer solution as the needle tip, and polyvinyl alcohol is used as the backing film composition material to support the microneedle dot matrix, so that the backing layer and the microneedle tip are closely bonded, thus the backing film and the needle tip can be consistently detached from the mold when the film is uncovered, and there is no needle breakage problem during the process.