Nuclear Receptor Screens Services

Puracyp offers single assays or panel screens at a discounted price. Our panels are designed to address the FDA’s recent guidance that CYP2B6, CYP1A2 and CYP3A4 induction by NCEs be evaluated. Puracyp’s cells contain the promoter/enhancer of these three P450 enzymes in addition to either CAR, AhR, or PXR. Panel screens are also useful for examining species differences in P450 induction and for toxicology studies using orthologs of human nuclear receptors. An example of results obtained in human cell lines utilizing our panel screen for PXR, AhR and CAR are shown below.