creative biogene -Oncolytic Virus
FromCreative Biogene
Oncolytic viruses (OVs) are a class of viruses that can selectively replicate in and lyse cancer cells, and subsequent spread with a tumor while not causing damage to normal cells. Besides the direct oncolytic activity, OVs are also effective in stimulating the body immune responses which can further help recogonize, control or destroy cancer cells. Through the combination of the tumor-specific cell lysis and immune stimulation, OVs act their antitumor activities in situ.
OVs encompass a broad diversity of DNA and RNA viruses, typically fall into 2 classes: 1) viruses that are naturally cancer-selective such as reovirus, 2) viruses that are genetically-manipulated including measles virus, adenovirus and herpes simplex virus (HSV-1) and so on.