Orthopedics & Pain Management Services
Orthopedics and pain management are the initial and most active research areas of Orthogen AG. Our methods find clinical application in these fields for over 25 years. We play a leading role in orthobiological discoveries and treatments.
Molecular orthopedics, as a major part of our research, has long shown that many orthopedic diseases are conditions not merely generated by mechanical wear and tear but result from a complex interplay of molecular and biochemical signals.
Most orthopedic diseases are impacted by inflammation, other biomolecular changes and often regenerative deficiency in the short- or long-term. These factors are ascribed to diseases of any tissue type including joints, nerves, muscles, tendons. We strive for resolutions on biomolecular level and the restoration of tissue health; for this can result in clinical success with a pain alleviating, function and quality of life improving effect.
To give an example: Osteoarthritis is a highly prevalent chronic disease with rising incidence, that could potentially affect anyone throughout lifetime. Osteoarthritis is commonly perceived as a widespread incurable but harmless condition. However, the disease actually constitutes an undervalued international health crisis. Osteoarthritis is associated with severe individual suffering, serious comorbidities, premature mortality and a large financial socioeconomic burden (OARSI White Paper, 2016).
Currently approved treatment options are largely palliative (suppressing symptoms) without a regenerative effect. In scientific consensus, the spectrum of currently available treatments is limited and lacks appropriate efficacy as well as safety. Many are associated with severe risks including cardiovascular diseases, gastric bleeding, persistent disability and premature death. Analgesics overuse cannot merely lead to severe consequences individually but also socioeconomically, as the opioid crisis has demonstrated.
We intend to address these issues with our platform technologies in a scientific, robust manner.
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