TOL Revolutionary Treatment for Advanced Cancer
Targeted Osmotic Lysis (TOL) is a revolutionary treatment for advanced cancer, combining a generic drug (a cardiac glycoside) with a proprietary pulsed electric field device.
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TOL operates at the cellular level on cancers (most cancers, mesothelioma) that overexpress sodium channels and pumps. We can block sodium pumps and sodium outflow using a cardiac glycoside. Then we electrically stimulate to open Voltage Gated Sodium Channels (VGSC), letting sodium into the cell. Because advanced cancer cells overexpress sodium channels by 10-50 times compared to normal tissue, normal cells take in less sodium, less water, and their compliant membranes let them swell but not rupture; when the drug wears off they return to normal. Cancer cells take in much more sodium, much more water, and explode.
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