Understanding NPDX ASD Test Results

The NPDX ASD Test v 2.0 is comprised of two metabolic panels that measure the levels of metabolites in blood plasma using Mass Spectrometry. One panel measures 32 amines (CPT Code 0063U) and the other panel measures 16 metabolites involved in energy metabolism, mitochondrial metabolites, microbiome derived products and others (CPT Code 0139U). Algorithmic analysis of these metabolite levels is used to identify 23 metabolic subtypes (metabotypes) known to be associated with autism spectrum disorder (ASD) classification using the ADOS-2 behavioural assessment as the reference method. The metabolic subtypes were validated in a clinical study of children 18-48 months old (1,2).