Cypre - 3D Tumor Model Platform
Cypre’s 3D Tumor Models combine the tumor, stromal and immune compartments in a high throughput format to screen targeted drugs and immunotherapy. In 2021, we partnered with Charles River to offer our 3D Tumor Models for drug discovery and preclinical screening services. Cypre Panels rapidly screen small molecules, biologics and cell therapy in 3D hydrogel in vitro tumor models.
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The tumor microenvironment (TME) involves the complex interplay of tumor, stromal and immune cell populations in an extracellular matrix. Successful cancer therapy - whether targeted or immunotherapy - must navigate the TME in order to reach and kill the tumor. Cypre’s 3D Tumor Models reconstruct the TME to assay therapeutic efficacy in a physiologically relevant setting.
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Tumor Growth
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Tumor Death
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Immune-mediated Killing
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T cell infiltration
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Cytokine multiplexing
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Immune profiling
A seamless workflow for growing 3D patient-derived tumors models and assaying targeted and immunotherapy drugs using high content analysis and advanced analytics (flow cytometry, cytokines).
For immunomodulators interrogating the innate or adaptive immune systems, or engineered immune cells (e.g. CAR-T) which require 3D TME analysis in vitro at high throughput, the Cypre 3D tumor model platform enables rapid efficacy assessment for your immunotherapy programs.
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Tumor Size
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Tumor Killing
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Immune Infiltration (e.g. CD45+)
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Cytokines
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Immune Phenotyping
Whether you are agnostically screening tumor indications or have a specific target in mind, Cypre tumor models rapidly screen pre-fixed and bespoke Panels which fit your needs and speed of execution, helping you accelerate to the next phases of your program.
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Tumor Size
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Tumor Death
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Apoptosis
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