Innovative technology, human expertise, and a clinical data sharing network: Clinical Genomics Knowledgebase enables you to identify and classify variants with confidence to help patients get the right answer the first time.
Genomic Variant Interpretations that are Clinically Derived
The Pierian Knowledgebase is not a variant lookup table. It's built on the foundation of a powerful rules engine that accurately delivers the richest set of rationalized medical interpretations from our clinical customers and Genomic Interpretation Services team, as well as expertly curated genomic data, clinical practice guidelines, FDA therapeutics, and clinical trials.
Rapid and Accurate
In addition to expertly curated sources such as NCCN/ASCO guidelines, FDA therapies, clinical trials, and published literature, our partner sharing network allows for the comparison of classifications and interpretations across medical directors at one or more sites. This unique aspect of the Pierian KnowledgeBase enables the use of real-world evidence to make knowledge assertions more rapidly and accurately.
The Pierian Knowledgebase encompasses over 10 megabases of sequence coverage (ten million genomic variants) and supports all variant types (eg. single nucleotide variants, insertions/deletions, copy number variants, and structural variants) for somatic cancer and germline applications, making it the most comprehensive genomic knowledgebase available.
All shared genomic interpretations in the Pierian Knowledgebase are expertly curated by our clinical customers or Interpretation Services team with an acute focus on their impact for clinical care. Each interpretation has medical oversight by our board certified Medical Director or is signed out directly by a board certified molecular pathologist or clinical geneticist.
With real-time publishing of medical interpretations and weekly updates to industry guidelines, FDA therapies and clinical trials, the Pierian Knowledgebase contains the most up-to-date and clinically actionable information for next generation sequencing data.