Surgical Scalpels Articles
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It turns out that p53 is destroyed in a whole new way
Glioblastoma is a deadly brain cancer with a dire prognosis. Unlike most cancers, it still grows in the presence of the p53 protein. Scientists have been unable to solve the case for decades...until now. CSHL scientists have discovered that a protein called BRD8 goes out of control in glioblastoma, paralyzing P53. The discovery could help turn this deadly cancer into a treatable disease. Brain ...
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A New Concept of Mosaicplasty: Autologous Osteoperiosteal Cylinder Graft Covered With Cellularized Scaffold
Abstract: A concern regarding osteochondral autograft transfer for chondral defects is donor-site morbidity of the knee, the most common source of the autograft. To avoid the drawbacks of osteochondral autograft transfer, a cylindrical osteoperiosteal graft harvested from the iliac crest covered by a same-sized cylinder of hyaluronic acidebased polymer scaffold pretreated with bone marrow ...
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Restriction Enzymes – Molecular Scalpels
The biological function of restriction enzymes is derived from the defense of foreign DNA from invading cells. The restriction-modification system of bacteria makes the DNA bases of bacteria to be methylated and modified, so that they are not recognized and cut by their own restriction enzymes. The development of restriction endonucleases In the early 1960s, Werner Arber came up with the idea ...
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What Are the 6 Steps for the Use of NovoSorb BTM?
NovoSorb® BTM (Biodegradable Temporizing Matrix) is a biocompatible device designed to temporize dermal injuries where tissue has been decimated or lost and to facilitate dermal repair by providing temporary wound closure and a scaffold for the generation of new dermal tissue. NovoSorb BTM is intended for single application and shouldn’t be applied into overtly infected wounds. ...
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Addressing Medical Negligence: Is It More Common than We Think?
It may surprise you to learn that the third most common cause of death in the U.S. is reputed to be medical negligence. The figures vary on the actual average number of deaths due to medical negligence each year. A John Hopkins study put the number at approximately 250,000 but other sources suggest it’s over 400,000 cases annually. The situation is so dire that the doctors involved with ...
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Suture Practice Kits - What It Should Include
Suture practice kits should be identical to the ones you use on the job. The goal is to familiarize yourself with the tools you use in a hospital or medical office setting. Practicing suturing is the best way to perfect the procedure, but only if your kit has the right tools. Here's what your suture practice kit should include. Used when applying intermediated-weight sutures, a Hegar Needle ...
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Detailed Introduction to Common Enzymes Used in Gene Cloning
The basic technology of genetic engineering is artificial cutting, splicing, and combination of genes. A gene is a DNA molecule with a certain function. To accurately cut out the DNA linear molecular fragments of different genes, various restriction endonucleases are required. To connect different fragments together, DNA ligase is required. To synthesize a gene or one of its fragments, DNA ...
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Best Material To Practice Your Suturing Skills
You've probably heard amazing stories of surgeons performing successful, yet extremely delicate and risky procedures such as open-heart surgery, separation of conjoined twins, craniotomy, thoracic aortic dissection repair, oesophagectom, spinal osteomyelitis surgery, and many more. As a medical student, you wonder how a surgeon can do such an incredible job. Well, the answer lies in lots of ...
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Cancer stem–like cells photothermolysed by gold nanorod–mediated near–infrared laser irradiation
Several studies have recently identified CD133 as a marker of cancer stem–like cells (CSCs) for various tumours. Such findings make CD133 a potential molecular target for tumour–selective therapeutic approach. In this study, fluorescence–tagged CD133 monoclonal antibody (anti–CD133) was conjugated to gold nanorods (GNRs), which are one of the anisotropic nanomaterials that can absorb ...
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