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Assay Product Applications For The Served Medical Health Care Industry
26 applications found
However, as applications increasingly rely on ultra low variant allele frequency detection, NGS-based assays are beset with significantly more noise below 0.5% VAF that increases the rate of false positives. Laboratories looking to implement ctDNA assays need better quality controls that can ensure accurate detection and reporting by variant calling algorithms.Standardizing within patient measurements and across sites and platforms are equally critical to ensuring accurate ...
ByAccuGenomics, Inc. based in Wilmington, NORTH CAROLINA (USA)
Real-time Viral Titer Assay Capability. Current viral titer assay methods, a crucial component of vaccine & CGT development and production efforts, are generally slow, labor intensive, subjective, and difficult to standardize, often resulting in large errors or failures during critical production ...
ByLumaCyte, Inc. based in Charlottesville, VIRGINIA (USA)
A challenge to widespread adoption of RNASeq transcript abundance measurement for clinical studies and diagnostics is yield biases between targets affecting accuracy and reproducibility of the assay. Implementing a unique molecular index (UMI) approach can reduce bias, but at a cost of >8 fold increase in read ...
ByAccuGenomics, Inc. based in Wilmington, NORTH CAROLINA (USA)
Their activities have generally been established by specific cellular and molecular assays to determine mode of action. While frequently well tolerated, side-effects are nevertheless commonplace and can be the result of unexpected interference with unintended pathways in poorly understood ways. ...
ByCambridge Protein Arrays Ltd. (CPAP) based in Cambridge, UNITED KINGDOM
Clinical diagnostics as e.g. measurement of bacteria in urine with a luciferase based assay of bacterial ATP can be used in the diagnosis of urinary tract infection (UTI). Screening for Duchenne’s Muscular Dystrophy (DMD) has been performed in 528,410 newborn boys in a German study. Luciferase based assays of ATP and ATP+AMP is more and more used to control hospital hygiene. ...
ByBioThema AB based in Handen, SWEDEN
With Quasi Vivo, Kirkstall’s flow system, you can quickly and easily set up and run in vitro assays to detect hepatotoxicity of novel compounds. ...
ByKirkstall Ltd. based in York, UNITED KINGDOM
Tracking SARS-CoV-2 viral strain evolution is critical for monitoring new regional outbreaks, contact tracing, infection control and verifying the performance of front-line RT-PCR diagnostic assays. Being able to report accurate sequence variations confidently, is critically ...
ByAccuGenomics, Inc. based in Wilmington, NORTH CAROLINA (USA)
In recent years, however, many examples have come to light where poor validation of antibodies has led to misleading or erroneous conclusions for assays in which they are used as reagents, due to unrecognised cross-reactions and even a failure to react with their supposed target altogether. ...
ByCambridge Protein Arrays Ltd. (CPAP) based in Cambridge, UNITED KINGDOM
The concept behind protein arrays is the immobilisation of sets of proteins, up to very large numbers, on solid supports, to perform miniaturised, multiplexed binding assays with a variety of potential ligands or interactants (see powerpoint presentation on right). ...
ByCambridge Protein Arrays Ltd. (CPAP) based in Cambridge, UNITED KINGDOM
Rheumatoid Arthritis (RA) is a common systemic autoimmune disease affecting between 0.5-1% of the adult population. RA is characterised by inflammation of the synovial joints which can lead to progressive joint destruction and consequently impair quality of life. ...
ByAxis-Shield Diagnostics Ltd. based in Dundee, UNITED KINGDOM
The Opto™ Cell Therapy Development workflow accelerates the creation of better therapeutics by performing multiple functional assays across 1,000s of individual T cells in a matter of days. Deeply characterize, profile, and map your T cell populations at the single-cell level to directly link phenotype to gene ...
ByBruker Corporation based in Billerica, MASSACHUSETTS (USA)
Radiance enhances the highly complex biomanufacturing process for cell therapies by providing new insights to cell therapy research and process development. Current process development assays are fraught with difficult and time-consuming steps requiring highly skilled scientists and bioengineers to produce these life saving treatments and ...
ByLumaCyte, Inc. based in Charlottesville, VIRGINIA (USA)
Combining the industry-standard Taqman assay with innovative engineering concepts, our XDive™ Superfast Real-Time PCR system can perform accurate pathogen detection, including the coronavirus, in as short as 5 minutes for 40 PCR cycles with no loss of sensitivity and ...
ByOnsiteGene Inc. based in San Diego, CALIFORNIA (USA)
The new standard for quality, capacity, and speed. Deliver the best cell lines. Set your IND up for success by getting FDA-accepted monoclonality assurance in just ...
ByBruker Corporation based in Billerica, MASSACHUSETTS (USA)
Determining adverse immune responses to monoclonal ...
ByAlcyomics Ltd. based in Newcastle Upon Tyne, UNITED KINGDOM
Determine the interactome of your favourite protein. HuProt arrays provide a primary platform for screening proteins for binary interactions with the world's largest collection of human proteins immobilised on a single microarray. Over 20,000 potential interactions are assessed in a single experiment. Array screening facilitates detection of interactors with low abundance in cellular systems. Combined with other data, the array output can confirm known interactors and discover new ones, illuminating the protein ...
ByCambridge Protein Arrays Ltd. (CPAP) based in Cambridge, UNITED KINGDOM
Protein arrays are exposed to enzymes to identify targets for post-translational modifications. Many key protein functions require the protein to undergo a post-translational modification (PTM), examples ranging from phosphorylations and glycosylations to histone modifications and ubiquitinations. HuProt human proteome microarrays can be used for profiling the targets of enzymes producing PTMs and have been used in studies of phosphorylation, glycosylation, sumoylation, ...
ByCambridge Protein Arrays Ltd. (CPAP) based in Cambridge, UNITED KINGDOM
Identify interacting proteins for your DNA/RNA molecule of interest. Profiling of nucleic acid binding on HuProt human proteome microarrays can reveal interactions with the largest collection of individual human proteins available on a single slide. Nucleic acid-protein interactions regulate many aspects of gene expression and thus cell physiology and pathology. DNA-protein interactions occur via a range of binding motifs present in transcription factors and nuclear receptors (e.g. DNA-binding domains, zinc ...
ByCambridge Protein Arrays Ltd. (CPAP) based in Cambridge, UNITED KINGDOM
The manufacture of biopharmaceutical agents such as therapeutic monoclonal antibodies, vaccines and cell-based therapies like CAR-T cells require the highest quality control against the contamination of adventitious agents. These pathogens can enter the manufacturing process at multiple stages and impact yield and safety. Current methods for detection of adventitious agents are expensive, lack sensitivity and have long turn around times to results. Moreover, many of the current adventitious agent testing methods ...
ByAccuGenomics, Inc. based in Wilmington, NORTH CAROLINA (USA)
Discover autoantigens in autoimmune diseases, delineate new candidate biomarkers. Autoantibodies are present in the blood of all healthy individuals. However, when directed at high levels against protein targets in specific tissues, autoantibodies can be a major cause of autoimmune diseases. They are also important biomarkers for diagnosis of these conditions. ...
ByCambridge Protein Arrays Ltd. (CPAP) based in Cambridge, UNITED KINGDOM