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Solid Tumour Product Applications
4 applications found
Several of the Navigo-created, ready-to-go Affilin molecules against solid tumor targets are currently developed as protein-drug conjugates (PDCs), by combining them to a half-life extending module and an engineered toxin-carrying moiety. Compared to notoriously difficult-to-produce and inhomogeneous Antibody-Drug Conjugates (ADCs), Affilin®-based PDCs have clear advantages. They are easily assembled from a specificity-conferring Affilin®, a half-life extending module and a toxin-carrying moiety. Each of ...
ByNavigo Proteins GmbH based in Halle, GERMANY
Solid tumor-specific Affilin molecules are currently being evaluated as CAR-T ligands. Specifically, they were confirmed to be functionally expressed on the effector cell surface, mediate target cell-binding and effective target cell-killing in a dose-dependent fashion. Importantly they were just as effective as commonly used antibody ...
ByNavigo Proteins GmbH based in Halle, GERMANY
A critical factor in ensuring complete resection of a solid cancer tumor is the ability to determine where diseased tissue ends and healthy tissue begins. Our research, as well as our clinical collaborators, confirm that there is a pressing unmet clinical need: the ability to rapidly and globally assess the status of marginal tissue adjacent to a tumor while the patient is in the ...
ByAkrotome Imaging, Inc. based in Cleveland, OHIO (USA)
Advances in diagnostic methods have enabled the detection of cancer at the earliest stages when the chances for successful intervention are highest. For many solid tumors, the best chance for a cure is surgery. A surgical cure depends upon the complete removal of all cancer tissue from a patient (a “complete resection”). The main challenge of this approach is that it is very difficult for a surgeon to determine where diseased tissue ends and healthy tissue begins. The result is that many surgical ...
ByAkrotome Imaging, Inc. based in Cleveland, OHIO (USA)