Microscope System for Drug discovery and development - Chemical & Pharmaceuticals - Pharmaceutical
In this example, the aggregation of magnetic nanoparticles labeled with DiR is monitored in real time. Tumor microvasculature is labeled using FITC-Dextran.
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Control experiment: non-magnetic nanoparticles do not aggregate during the application of a magnetic field..
Magnetic nanoparticles aggregate during the application of a magnetic field. They aggregate near the tumor vessel wall. No vascular damage is observed.
Videos courtesy of K. T. Al-Jamal, Drug delivery group, Institute of Pharmaceutical Sciences, King's College London, UK.Article reference: Real-time monitoring of magnetic drug targeting using fibered confocal fluorescence microscopy. Journal of Controlled Release, 10.1016/j.jconrel.2016.07.026Effect drug treatment on tissue vasculature
This video confirms the integrity of the blood-brain barrier after epilepsy treatment.