antiviral drug Articles
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Significance of fomites in the spread of respiratory and enteric viral disease
Worldwide annually there are 1.7 million deaths from diarrheal diseases and 1.5 million deaths from respiratory infections (56). Viruses cause an estimated 60% of human infections, and most common illnesses are produced by respiratory and enteric viruses (7, 49). Unlike bacterial disease, viral illness cannot be resolved with the use of antibiotics. Prevention and management of viral disease ...
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Demographic projections of future pharmaceutical consumption in the Netherlands
Over the next few decades, many Western European countries will undergo a large demographic transformation introduced by the retirement of the "baby boomers" and the possibility of striking increases in longevity. The aim of this study was to estimate the effect of a growing and ageing Dutch population on the future consumption of pharmaceuticals, so as to be able to anticipate the potential ...
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The 3rd AIDS patient is "cured"! Has mankind finally conquered AIDS?
At an academic conference on Feb 15, U.S. experts announced the world's first female AIDS "cure," making it the third case of HIV infection to be cured. After therapy and withdrawal of antiviral drugs, HIVs were not identified in the patient's body for more than 14 months, indicating that the virus was in complete remission, according to academics. The key to this patient's recovery was a blood ...
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Huateng Pharma Supplies Ensitrelvir Intermeidates Against COVID-19
Ensitrelvir (code name S-217622, brand name Xocova), is a new inhibitor of the SARS-CoV-2 major protease (Mpro), also known as 3C-like protease, has been shown to reduce the viral load and help alleviate the severity of SARS-CoV-2 in infected hamsters. In cells, low nanomolar to sub-micromolar doses of Ensitrelvir suppress viral growth. In hamsters, oral treatment of Ensitrelvir showed excellent ...
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Protein-DNA Docking in Drug Discovery: Identifying Small Molecules for New Drug Development
Protein-DNA docking is a complex and critical technique used in the field of structural biology. It involves the study of the three-dimensional structure of biological macromolecules, which play vital roles in many biological processes such as transcription, replication, and DNA repair. Protein-DNA docking allows researchers to predict how proteins and DNA interact with each other, providing ...
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Rational`s Experimental Herpes Vaccine Shows Preclinical Promise
Rational Vaccines said findings from a pilot study showed that RVX201 led to a reduction in recurrent genital lesions when compared to gD2-alum/MPL vaccine in animal studies. Rational's Experimental Herpes Vaccine Shows Preclinical Promise Rational Vaccines said findings from a pilot study showed that RVX201 led to a reduction in recurrent genital lesions when compared to gD2-alum/MPL vaccine ...
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New structural target against COVID-19
A new structural target for drug development against COVID-19 has been unveiled today by Sibylla Biotech in collaboration with the Italian National Institute of Nuclear Physics (INFN), the University of Trento and University of Perugia.The breakthrough drug discovery strategy pioneered by Sibylla in this study would not only promise to reduce the risk of drug resistance and harmful side effects, ...
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Unraveling the Complexity of Glycans: Exploring Glycan Arrays and Their Applications
Introduction Glycans, also known as carbohydrates, are complex molecules that play a crucial role in various biological processes. They are involved in cell signaling, immune responses, and cell adhesion, among other functions. Glycan arrays have emerged as powerful tools for studying the interactions between glycans and other molecules. In this blog post, we will delve into the world of glycan ...
By CD BioGlyco.
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Applications of Liposomal Drug Delivery System Technology
Liposomes are a novel drug delivery system (DDS). They are bimolecular vesicles that form spontaneously when phospholipids are dispersed in water. Liposomes vary in size, composition and charge and can be used as carriers for a wide range of drug molecules, such as chemotherapeutic agents, antimicrobial and antiviral drugs, antiparasitic drugs, genetic material, vaccines, therapeutic proteins, ...
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An Overview of the Lipase and Its Industrial Applications
Lipase, also known as glyceride hydrolase, is a glycoprotein composed of 2%-15% sugar bases, the basic unit of which is mannose. Lipase exists in fat-containing animal, plant and microbial (such as mold, bacteria, etc.) tissues, including phosphatase, sterolase and carboxylesterase, fatty acids are widely used in food, medicine, leather, daily chemicals, etc. The Role of Lipase Lipase is an ...
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Nipah virus glycoprotein structure suggests therapeutic strategies
Recent molecular discoveries have provided new details on how Nipah and Hendra viruses attack cells, and the immune responses that fight back against this attack. The findings point to a multi-pronged strategy for preventing and treating these deadly diseases. The study was published in Science recently. Both Nipah virus and Hendra virus are carried by indigenous bats in some parts of the ...
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How to activate the "first responders" of the immune system - NK cells
About NK Cells Natural Killer (NK) cells play a critical role in the innate immune surveillance against cancer and viral infections. They are the "first responders" capable of spontaneously recognizing abnormal cells in the body, swiftly eliminating them through targeted cytotoxic mechanisms, and effectively producing pro-inflammatory cytokines and chemokines to recruit and activate other immune ...
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Influenza A virus replication has a stronger dependency on Raf/MEK/ERK signaling pathway activity than SARS-CoV-2
The recent COVID-19 pandemic again highlighted the urgent need for broad-spectrum antivirals, both for therapeutic use in acute viral infection and for pandemic preparedness in general. The targeting of host cell factors hijacked by viruses during their replication cycle presents one possible strategy for development of broad-spectrum antivirals. By inhibiting the Raf/MEK/ERK signaling pathway, ...
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Coronavirus: continued updates in basic research, vaccine development and testing
Researchers have delved further into our understanding of coronavirus, while the race to develop a vaccine continues. New advances in coronavirus understanding New research has put paid to some of the conspiracy theories surrounding coronavirus. A team comprising researchers from both the US, Australia and the UK has analyzed the receptor-binding domain (RBD) and the cleavage site present on ...
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Comprehensive protein interaction network helps discover candidate drugs for the treatment of COVID-19
Treatment options for COVID-19 remain limited. Researchers at the University of Helsinki and the University of Eastern Finland first searched for appropriate drug targets and reusable drugs and finally discovered six candidates with antiviral effects against SARS-CoV-2. Understanding viral pathogenesis at the molecular level is key to the development of effective therapies for COVID-19. The ...
By Profacgen
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Using AI to Fight a Pandemic: Insilico Medicine Announces Novel Preclinical Candidate for COVID-19 Treatment
Insilico Medicine announced the nomination of a novel preclinical therapeutic candidate for treating COVID-19, designed using the generative chemistry AI platform Chemistry42. The new drug candidate is a 3CL protease inhibitor unique from existing drugs in its class because it can be rapidly produced. While this nomination is a potentially important development for the ongoing COVID-19 pandemic ...
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The Crucial Role of Cytokines in Biomedical Research and Drug Development
Low Endotoxin Cytokines Matters Organoid culture, CAR-T cell therapy, stem cell therapy, and other topics have become broadly discussed among biomedical researchers. In fact, it is not difficult to see that these advanced technologies are all related to cell culture. In order to maintain efficient growth, proliferation, and differentiation during in vitro cell culture, many cell cultures require ...
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