cancer drug Articles
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Preparation and characterisation of 5–fluorouracil containing PLGA nanospheres coated with chitosan, for drug delivery
The aim of this study was to design a new Drug Delivery System (DDS) based on poly (lactide–co–glycolide) (PLGA) biodegradable nanospheres (NS) coated with Chitosan (CTS), in order to prolong its residence time and to deliver the nanoparticles more specifically to cancer cells. We have tried three methods of incorporation of Chitosan in the nanoparticles, but only one was efficient. The first ...
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Gold nanoparticle–based platforms as cancer–targeted molecules delivery systems
Cancer is a major cause of deaths. More recently, drug delivery systems (DDSs) using gold nanoparticles (GNPs) have been widely developed in cancer therapy for their easily synthesised, functionalised, better biocompatible, and low toxicity properties. Gold nanoparticle–based platforms as cancer–targeted molecules delivery to tumour tissues have been proposed as an effective strategy by ...
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Novel nanoplatform for oral delivery of anti–cancer biomacromolecules
Oral administration of bio–macromolecules is an uphill task and the challenges from varying pH and enzymatic activity are difficult to overcome. In this regard, nanotechnology promises the new hope and offers advantages such as controlled release, target specific delivery, combinatorial therapy and many more. In this study, we demonstrate the formulation of a novel alginate enclosed, chitosan ...
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Curcumin loaded organically modified silica (ORMOSIL) nanoparticle; a novel agent for cancer therapy
Curcumin is a polyphenol compound extracted from the rhizome of turmeric (Curcuma longa) and has a well established anticancer property. However poor aqueous solubility is a major hindrance for its bioavailability and therapeutic use. Nanoparticle based system can be developed to overcome this problem. Present study has been undertaken with curcumin loaded organically modified silica (ORMOSIL) ...
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Nanodrug potential in cancer therapy: efficacy/toxicity studies in cancer cells
The interest of nanotechnology to find a more effective approach for drug delivery is growing fast. Nanoparticles as drug vehicles potentially improve the pharmacokinetic and pharmacodynamic properties of various types of drugs, and provide a tool to visualise molecules and tumour target cells that otherwise cannot be detected through conventional imaging. However, there are many aspects of ...
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Institute of Cancer Research Makes Groundbreaking Treatment Discoveries With NM30LA - Case Study
The Institute of Cancer Research or ICR, is a world leading institution in cancer gene discovery, cancer drugs and innovations in radiotherapy. With the help of Peak's NM30LA gas generator ICR have managed to streamline their workflow. Name: Amin Mirza Job title: Head of Structural Chemistry Company: Institute of Cancer Research Location: London, UK One of ICR’s main priorities is to ...
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Regulation of abcg2 expression at the 3` untranslated region of its mrna through modulation of transcript stability and protein translation by a putative microrna in the s1 colon cancer cell line
ABCG2 is recognized as an important efflux transporter in clinical pharmacology and is potentially important in resistance to chemotherapeutic drugs. To identify epigenetic mechanisms regulating ABCG2 mRNA expression at its 3' untranslated region (3'UTR), we performed 3' rapid amplification of cDNA ends with the S1 parental colon cancer cell line and its drug-resistant ABCG2-overexpressing ...
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Synthesis and characterisation of new designed protoporphyrin-stabilised gold nanoparticles for cancer cells nanotechnology-based targeting
Nanotechnology has entered the field of medicine in recent dacades and especially, in drug delivery systems, nanoparticles have shown an ability to improve pharmacokinetics, pharmacodynamics, efficacy and to reduce the toxicity of associated drugs. In this study, we have designed a new protoporphyrin-conjugated gold nanoparticle to selectively target and photo- or sonodynamic therapy of tumoural ...
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Nuclea Launches Strategic Partnership with Aelan in Field of Epigenetics
CAMBRIDGE, MA--(Marketwired - Jun 30, 2015) - Nuclea Biotechnologies Inc. announced today that it is partnering with Aelan Cell Technologies Inc. (San Francisco, California) for the development, validation and commercialization of novel biomarker tests and companion diagnostics using human STEM cells as models. Their collaboration has the potential to impact disease monitoring and drug ...
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Structural Characteristics and Functions of Glycoproteins, Proteoglycans and Glycolipids
Sugar is an important nutrient for the human body, and its primary physiological function is to provide energy and carbon sources for life activities. In addition, sugar also participates in the composition of glycoproteins and glycolipids, and regulates cell information transmission. Monosaccharides are polymerized by glycosidic bonds to form oligosaccharides or polysaccharides, also called ...
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Ozette’s computationally-driven analysis aids advancement of cancer drug development - Case study
Summary Inflammation is a hallmark of the tumor microenvironment and an area of active investigation. To better understand how tumor inflammation differs from general inflammation, such as in gum disease, Drs. Prilic, Mair, and Erikson employed novel methods, which included high parameter flow cytometry and Ozette’s foundational technology–full annotation using ...
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Augmentation of anti–tumour activity of cisplatin by pectin nano–conjugates in B–16 mouse model: pharmacokinetics and in–vivo biodistribution of radio–labelled, hydrophilic nano–conjugates
Nanoconjugates have matured from simple devices to multifunctional, biodegradable, non–toxic and non–immunogenic constructs, capable of delivering synergistically functioning drugs in vivo. The present study evaluates the efficacy of drug polymer self folding nano–conjugates of pectin–cisplatin to enhance blood circulating levels of cisplatin. Physical characterisation was done by DLS, zeta ...
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Applications of nanotechnology in drug delivery systems for the treatment of cancer and diabetes
This paper discusses potential applications of nanotechnology in drug delivery systems and pharmacotherapeutics. There are a few limitations in the use of conventionally available drug delivery systems as pharmacological agents in disease treatment. Lack of target specificity, altered effects and diminished potency due to drug metabolism in the body, cytotoxicity of certain anti-carcinogenic ...
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Mesoscopic studies on toxic effect of doxorubicin on rat cardiac muscles
The anthracycline antibiotic doxorubicin (DOX) is one of the most effective anti-tumour agents used to treat human malignancies. Long-term treatment with DOX is limited by its cardiotoxicity. The purpose of the present study was to evaluate the cardiotoxic effect of DOX using nanoscale. Twelve adult male rats were divided into two groups: control group, group 2A, DOX one week (DOX 1wk), group2B, ...
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Symberix Featured in Nature
Durham, NC (February 3, 2020) - An article in Nature highlights Symberix's efforts to understand the complex relationship between drugs and the microbiome. The paper discusses recent contributions to the emerging field of “pharmacomicrobiomics” -- the study of how microbes impact drug disposition, efficacy, and toxicity. Symberix is developing bacteria-targeted small molecules that ...
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Hoffmann-La Roche - Ozone oxidation for the elimination of active pharmaceutical ingredients from wastewater - Case Study
Hoffmann-La Roche has set up a new facility in Toluca, Mexico for the production of two highly effective cancer treatment drugs. The wastewater generated in this context poses an ecotoxicological risk. Therefore, it needs to be eliminated at the source. Various methods were tested and evaluated from an ecological and economic perspective. According to preliminary studies, the best way to ...
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Structure-based Design of Protein Kinase Inhibitors
Protein kinases are effective anti-cancer drug targets that have been proven in many experiments and facts. Many small molecule protein kinase inhibitors approved by the FDA can be used for cancer treatment. The effectiveness of kinases as targets for other diseases, including neurological disorders, inflammation and metabolic diseases, is also being tested. Human protein kinase consists of more ...
By BOC Sciences
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Idience: developing selective and potent PARP inhibitor IDX-1197 for solid tumors
The first wave of PARP inhibitors has improved outcomes in people with a variety of solid tumors. However, Idience has identified opportunities to improve the efficacy of existing drugs and overcome resistance. The company plans to target homologous recombination repair-proficient patients with a clinical-phase PARP inhibitor that is now available for licensing. Ildong Holdings, a major ...
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Non–covalent surface integration: optimising a novel technique for preparing targeted polymeric nanoparticles for cancer therapeutics
Targeting anticancer drugs to their specific molecular targets is a major challenge in cancer therapy. However, advances in biomedical and protein engineering have led to novel nanoparticle targeting approaches. In this study, we used a novel non–covalent insertion of a homo–bifunctional spacer for targeted delivery of drugs to various cancer cells. Functionalised blank nanoparticles for antibody ...
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New Method to Produce Ring-Opening Metathesis Polymers with Facile Degradability
A team of chemists at MIT has formulated a method to produce polymers that can disintegrate more readily in the body as well as in the environment. A new type of polymer designed by MIT chemists incorporates a special monomer (yellow) that helps the polymers to break down more easily under certain conditions. (Image credit: Demin Liu) A chemical reaction known as ring-opening metathesis ...
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