clinical significance Articles
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Management of Type 2 Diabetesusing non-invasive CGM
There is compelling evidence suggesting Type 2 diabetes may be managed by use of a Continuous Gucose Monitor (CGM) on non consecutive days, leading to clinically significant outcomes. Invasive CGMs are generally designed for wear periods of up to 14 consecutive days: with the associated cost. The additional costs are not justified where significant clinical outcomes can potentially be achieved ...
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Clinical significance of low-dose radiation therapy: radiation hormesis
This study was designed to investigate the clinical significance of low-dose radiation therapy, radiation hormesis, and accuracy of therapeutic regimen. Radiation hormesis was performed in six patients (four patients with malignant diseases and two patients with benign diseases) in the experimental room where they could be exposed to a low level of direct gamma ray and inhale radon gas ...
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Detailed Introduction to Clinical Significance of Amylase
As a kind of enzymes for diagnostic use. Serum amylase (AMS) is the main type of amylase in serum. It belongs to glycoside chain hydrolase, which is mainly derived from the pancreas. In addition, there are also a small amount of secretion in the proximal duodenum, lung, uterus, and breast during lactation. Amylase plays an important role in the digestion of polysaccharide compounds in food. The ...
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Case Study B - Liquid Biopsy
X-ZELL is collaborating with Singapore General Hospital (SGH) and the National University Hospital Singapore (NUH) to explore how X-ZELL single-cell diagnostics may aid in the early detection of clinically significant prostate cancer in whole blood. The prospectively blinded, 400-patient multi-centre study officially commenced in 2020 and will lay the foundation for the launch of a commercially ...
By X-Zell Inc.
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Validation of ClarityDX Prostate as a Reflex Test to Refine Prediction of Clinically Significant Prostate Cancer: ClinicalTrials.gov ID: NCT03957252
Summary This study is designed to determine the accuracy of the blood test ClarityDX Prostate to predict the results of prostate biopsies in men who have PSA (Prostate Specific Antigen) greater than 3 and no higher than 10 ...
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Value of BWT Measurement in Bladder Scanner
Being the first bladder scanner in the world which can measure BWT bladder wall thickness, M5 makes it possible that BWT can be monitored easily and quickly on daily basis. This feature fosters research on coorelation between BWT and different urological diseases. During the interview with Dr. Xu Kexin from Peking University People's Hospital whose team has been using M5 for about one year, we ...
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Filling Gaps in PTSD Care
People who live with trauma symptoms—and the people who care for them—know how challenging the condition can be to treat. Medications and talk therapy help many patients, but are ineffective for many others. The search continues for treatments that work and offer lasting benefits for the millions of Americans who live with PTSD. Sources of trauma Though PTSD is linked with ...
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Assessment of a urinary TRUS/biomarker-based risk score as inclusion criteria for multiparametric MRI to detect clinically significant prostate cancer
BACKGROUND Non-invasive techniques like urinary biomarkers and multiparametric Magnetic Resonance Imaging (mpMRI) show great promise for the detection of clinically significant prostate cancer (PCa), leading to a reduction of over-diagnosis and over-treatment. Apart from yet to be established diagnostic accuracy is the systematic use of mpMRI challenging due to the high cost of setting up, ...
By MDxHealth
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Nanostics Announces Study Data Supporting ClarityDX Prostate as a Reflex Test to Predict Clinically Significant Prostate Cancer
Real-world data shows that at a 94% sensitivity level for prostate cancer ClarityDX Prostate® is 147% more specific than the PSA test for predicting clinically significant prostate cancer. Using ClarityDX Prostate® as a reflex test vs. PSA test alone could have resulted in 37% fewer unnecessary biopsies. The clinical study recruited men from two sites in Alberta, Canada, and one site ...
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Nanostics Receives CE Mark for its ClarityDX Prostate Test to Detect Clinically Significant Prostate Cancer
Nanostics’ biomarker and machine learning-powered test, ClarityDX Prostate®, received a CE-IVD Mark. A CE-IVD Mark is required for all in vitro diagnostic (IVD) devices to be placed in the European Economic Area, Iceland, Norway, and Liechtenstein and allows Nanostics to market and sell ClarityDX Prostate® in these countries. The ClarityDX Prostate® test provides patients ...
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Landmark Study Shows a 0% Blood Culture Contamination Rate is Achievable with Steripath
As a professor in infectious disease and microbiology, epidemiologist, and Medical Director of Infection Prevention and Control at Stanford Health Care, Dr. Lucy S. Tompkins was skeptical that a 0% blood culture contamination rate could be achieved, especially in a major academic medical center. Study Results In an oral abstract of the Steripath Gen2 Initial Specimen Diversion Device® ...
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Cost-Effectiveness of Urinary Biomarker Panel in Prostate Cancer Risk Assessment
Abstract Purpose: SelectMDx (MDxHealth®) is a panel of urinary biomarkers used in conjunction with traditional risk factors to individualize risk prediction for clinically significant prostate cancer. In this study we sought to characterize the effectiveness of SelectMDx in a population of American men with elevated prostate specific antigen. Materials and methods: We developed a ...
By MDxHealth
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Nanostics Re-Opens ClarityDX Prostate Clinical Study with New US Recruitment Site
Summary Nanostics' clinical validation study for ClarityDX Prostate, a liquid biopsy test for the early diagnosis of clinically significant prostate cancer, re-opens recruitment after lifting of COVID-19 research restrictions A top-ranked research institute in the Northeast US will now partner with Nanostics' by recruiting patients for the clinical validation study This partnership will ...
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Impact of low anterior resection syndrome (LARS) on quality of life
Low anterior resection syndrome (LARS) has a substantial negative impact on quality of life and almost 70% of patients experienced major LARS 1-11 years after rectal surgery. Rectal cancer patients experience symptoms of low anterior resection syndrome (LARS) several years after their rectal surgery with a substantial impact on quality of life (QoL) as shown in this observational cohort study. ...
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Validation of a two-gene mRNA urine test for detection of high-grade prostate cancer in German men.
Organizations Martini-Klinik Prostate Cancer Center and Department of Urology, University Hospital Hamburg-Eppendorf, Hamburg, Germany, MDxHealth, B.V., Nijmegen, Netherlands, MDxHealth, Inc., Irvine, CA, Mathematical Modeling, Statistics and Bioinformatics, Ghent University, Ghent, Belgium, Martini-Klinik Prostate Cancer Center, University Hospital Hamburg-Eppendorf, Hamburg, Germany Abstract ...
By MDxHealth
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Inhalation vaccine promises to be a powerful tool in the prevention and control of Omicron
Omicron, as the most transmissible variant of SARS-CoV-2, is rapidly spreading over the world and has displaced Delta as the dominant strain in a number of regions. Some experts have indicated that mucosal immunization of the respiratory system with an inhaled form of the vaccine may be more efficient in dealing with the Omicron strain in light of recent results that demonstrate Omicron ...
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Freehand Transperineal Biopsy
“Freehand transperineal biopsy” seems to be the latest buzzword in the urology world, and for good reason. Compared to transrectal, transperineal is proven to be the cleaner and ultimately safer approach for prostate biopsies. The support for transperineal is growing, as mounting evidence continues to debunk previous misconceptions of tolerability, feasibility and accuracy. We ...
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Nanostics Announces the Launch of its Bladder Cancer Clinical Study Identifying Disease Predictors for Early Detection of Bladder Cancer
Clinical study launched in June 2022 with patient recruitment in Alberta with plans to expand to further sites across North America. The aim of the study is to validate a novel and minimally invasive liquid biopsy test for bladder cancer diagnosis using Nanostics’ ClarityDX® diagnostic platform. The study is supported in part by the Alberta Innovates AICE-Concepts Program with a ...
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UK Team to Test Robot-assisted Exercise to Improve Balance in MS Patients
Researchers at Kent and Canterbury Hospital, U.K., are recruiting 20 patients with multiple sclerosis (MS) who can walk at least eight meters with a walking aid to test the effectiveness of a five-week exercise program using assistive robotic technology. A patient completes balance and strengthening exercises using the Rex robot. (Photo courtesy of East Kent Hospitals University NHS ...
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One leg test balance! Very challenging
Standing on one leg is an essential task in activities of daily living (ADLs), from walking to stair climbing, shower transfer and lower body dressing (while standing). Besides that, it is necessary in many occupational and sports activities, making it an important stance to be included within a balance assessment session. One-leg stance duration is one the oldest balance tests using a simple ...
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