Clinical Study And Develop Articles & Analysis
68 articles found
For centuries outbreaks of numerous diseases called pandemics would plague human populations in large regions or even world-wide. Throughout history there have been a number of widespread pandemics the most devastating being the Black Death pandemic that killed over 75 million people in the 1350’s and the latest being influenza outbreaks, also known as the Spanish flu, in 1918 and ...
Preclinical drug discovery represents a critical phase in the development of new therapeutics. It is the process that bridges the gap between basic research and clinical testing, allowing for the evaluation of potential drug candidates in biological systems before they are tested in humans. ...
These cell lines serve as essential models for studying the biology of colorectal cancer, testing new therapies, and exploring the mechanisms of drug resistance. ...
Recombinant protein drugs refer to protein products that originate from animals and plants and are developed through biotechnology research. These protein drugs exhibit certain biological activity and can prevent, diagnose, and treat diseases in humans, animals, and plants. Compared with small molecular drugs, recombinant protein drugs offer advantages such as high activity, high specificity, and ...
What Is PROTAC Technology? Proteolytic targeting chimera (PROTAC) is a new type of drug design technology that works by inducing the degradation of target proteins. Unlike conventional small molecules that typically inhibit protein function, PROTACs facilitate the ubiquitination and subsequent degradation of specific proteins. This bifunctional molecule consists of two distinct elements: a ...
Medical advancement relies on clinical trials, which are essential for the development of safe and effective innovative treatments. However, the success and general applicability of these treatments heavily depend on the diversity of the participants involved¹?³. This blog explores the importance of achieving data diversity in clinical trials to enhance clinical trial results and ...
When we talk about antibody sequencing, we often think of issues related to disease treatment and improving human health. Nanobody sequencing provides us with a more precise and efficient solution. Nanobodies, also known as single-domain antibodies, are antibodies composed of a single functional domain. They have the advantages of small size, high stability, and good penetration, and therefore ...
Dr. Kate Sasser from Tempus led a discussion on the potential of antibody-drug conjugates (ADCs), their challenges in targeting tumor antigens, and the future of cancer treatment with Dr. Daniel Johnson, Dr. Funda Meric-Bernstam, and Dr. Kellogg Parsons. The oncology field is rapidly advancing with the development of antibody-drug conjugates (ADCs), offering new hope for ...
ByTempus
Currently, RDC drugs have made significant breakthroughs in cancer treatment alongside the development of antibody drugs and ADCs. Antibodies are relatively effective for hematologic malignancies. ...
Therefore, nanobodies are preferred tracers with wide applications in the field of molecular diagnostics.Non-invasive molecular diagnostics based on nanobodies are in the development stage. Studies have reported that EGFR nanobodies labeled with radioactive element 99mTc can accurately detect EGFR-positive tumor cells. ...
Therefore, there is a need to deepen our understanding of the physical, chemical, and biological properties of these adjuvants to provide a theoretical basis for determining the quality attributes of each adjuvant and selecting the appropriate type of adjuvant as early as possible in the clinical development phase. Type of Aluminum Adjuvants The two main types of ...
Maternal serum samples were collected between 20 and 37 weeks of gestation. Clinical suspicion of preeclampsia was defined as presence of new-onset proteinuria, or clinical symptoms of preeclampsia. Subjects with a clinical diagnosis of preeclampsia at the time of enrollment were excluded. ...
The opioid crisis in the United States is a devastating public health issue, with over 70,000 overdose deaths annually, largely driven by the highly potent synthetic opioid fentanyl. The urgency to address this crisis has spurred the development of innovative therapies to prevent and reverse fentanyl overdoses. In this blog, we will explore the groundbreaking preclinical work on CSX-1004, a fully ...
With the rapid development of antibody-drug conjugate (ADC), more and more companies have entered the field of ADC research and development, and various types of ADC technologies and branches have emerged. ...
By profiling patient samples using scRNA-seq, researchers can identify cell types that are relevant to the disease and develop more accurate disease models. These models can be used to study disease progression, test drug candidates, and gain insights into drug mechanisms of action. In the clinical development phase, ...
As of January 1, 2023, global vaccine development includes a total of 966 vaccine candidates, of which 23% (220) are traditional inactivated or attenuated vaccines. Advances in molecular technology have facilitated the development of other platforms, such as recombinant protein vaccines, nucleic acid vaccines, and viral vector vaccines, which have further diversified global vaccine development. ...
Profiling patient samples using scRNA-seq helps identify cell types relevant to the disease and develop more accurate disease models. These models facilitate the study of disease progression, testing of drug candidates, and gaining insights into drug mechanisms of action. During the clinical development phase, scRNA-seq informs ...
Patricia A. Pellikka from Mayo Clinic will share some of the evidence around EchoGo® Heart Failure, including her research with Ultromics and her involvement in the development of their AI algorithm. ...
After more than 20 years of development, ADC biopharmaceuticals are becoming the main force in the treatment of cancer. ...
Preliminary results of a large-scale study demonstrating the clinical benefits of EchoGo® Heart Failure were shared at the American College of Cardiology (ACC 2023) conference last month. ...