Cytokine Il Articles & Analysis
23 articles found
What Are Cytokines and Chemokines? Cytokines are small proteins secreted by cells that have a profound influence on the behavior of other cells. ...
Additionally, several cytokines are undergoing clinical trials, including interleukins like IL-1, IL-3, IL-4, IL-6, and IL-11, as well as transforming growth factor beta (TGF-β) and macrophage colony-stimulating factor (M-CSF). ...
Th2 cells mediate humoral immune responses by secreting cytokines such as IL-4 and IL6, which promote B-cell differentiation and antibody production. ...
In a mouse model, oral administration of IL-22 mRNA-loaded LNP significantly increased IL-22 expression in the colonic mucosa and accelerated the healing of colitis. ...
The IL-1 superfamily of cytokines includes IL-1α, IL-1β, IL-33, IL-1Ra, IL-18, IL-37, IL-36Ra, IL-36α, IL-36β, IL-36γ, and IL-38, which play important ...
The results showed that the activation of NF-κB was inhibited in the treated mice, and inflammatory cytokines TNF-α, IL-6 and IL-1 showed a decreasing trend, and intestinal inflammation was improved. ...
Cytokine Involvement in Rheumatoid Arthritis (RA) RA, an immune-related polyarticular inflammatory disorder, involves a spectrum of cytokines, including IL-1B, IL-6, IL-12, IL-15, and TGF-β. ...
Studies show that IL-17F and IL-17A have a synergistic effect: unlike inhibiting IL-17A alone, inhibiting these two cytokines at the same time can significantly increase the down-regulation of inflammatory mediators in skin and joint fibroblasts. ...
N-terminally truncated IL-36α, IL-36β, and IL-36γ are 1000 to 10,000 times more active than the non-truncated cytokines, and the antagonistic activity of IL-36Ra depends on the removal of its N-terminal glutamic acid. ...
Indeed, it has been suggested that the overexpression of cytokines IL-17 and IL-6 by Th17 could contribute to the maintenance of pathogenic inflammatory phenomena and to the production of autoantibodies. ...
Cytokines-mediated signaling is a primary way of immune system communication. The common gamma-chain family of cytokines is a set of six cytokines that signal through the common cytokine γ chain receptor (γc/CD132/IL2RG). These cytokines include IL-2, IL-4, ...
More importantly, this new therapy has been validated in mouse solid tumor models of melanoma and pancreatic cancer, providing new strategies for the study and application of adoptive T cells in the treatment of solid tumors. IL-2 is a cytokine required for proliferation, survival, and functional maintenance of effector T cells and is an important therapeutic ...
The results showed that the intestinal inflammation was improved in the treated mice since the activation of NF-κB was inhibited and the inflammatory cytokines TNF-α, IL-6, and IL-1 were reduced. 4. Bactericidal Effect Broad-spectrum antibiotics are difficult to inhibit or kill intracellular bacteria, which cause great harm to ...
Various immune cells in the body such as macrophages, neutrophils, natural killer cells and dendritic cells can release various cytokines, such as IL-1, IL-2, IL-6, IL-8, IL-10, IL-12, chemokines, granulocyte colony-stimulating factor, granulocyte megakaryocyte colony-stimulating ...
Researchers at The University of Texas MD Anderson Cancer Center have identified a new strategy to reduce immune-related adverse events by targeting immunotherapy with the cytokine interleukin-6 (IL-6). The study, published in Cancer Cell, provides evidence for the concept of combining immune checkpoint blockers and cytokine blockers to ...
Pro-inflammatory Cytokines Interleukin-1 (IL-1) IL-1 is a proinflammatory cytokine that activates a variety of immune and inflammatory cells and is secreted mainly by monocytes/macrophages, neutrophils and endothelial cells. ...
CTLA-4 is highly expressed in regulatory T cells, where it interacts with the same ligands as the T cell co-stimulatory receptor CD28 but with a higher affinity. IL-2 therapy The use of the cytokine IL-2 to selectively amplify Treg cells is another immunotherapeutic strategy for targeting T cells. Because of IL-2's role in ...
Tumor Necrosis Factor Alpha (TNF-a) is a potent cytokine that is over-expressed by cells during chronic intestinal inflammation. Furthermore, TNF-a represents the most validated clinical target for ulcerative colitis (UC) and inflammatory bowel diseases (IBD) with multiple emerging neutralizing/inflammation-reducing therapeutics targeting this cytokine for ...
Various colitis symptoms of mice, including disease activity index score [4.55 ± 0.99 (P < 0.001) and 5.12 ± 0.94 (P < 0.001), respectively], colon length [6.18 ± 0.43 mm (P < 0.001) and 6.62 ± 0.47 mm (P < 0.001), respectively], and colon histological score [(5.33 ± 1.03 (P < 0.001) and 4.00 ± 0.89 (P < 0.01), respectively)], were ...
Effects of oral administration ofL. rhamnosus KBL365 orL. paracasei KBL382 on Th1, Th2, Th17, and anti-inflammatory cytokine production in the skin of AD mice. Protein levels of the T helper (Th)2-type cytokines (A) interleukin (IL)-4, (B) IL-5, and (C) IL-13, Th1-type cytokine (D) IFN-γ, ...