cytokine interleukin Articles
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Inflammatory Cytokines Profile
Cytokines are classified according to their different roles in the inflammatory response: pro-inflammatory cytokines and anti-inflammatory cytokines. Pro-inflammatory Cytokines Interleukin-1 (IL-1) IL-1 is a proinflammatory cytokine that activates a variety of immune and inflammatory cells and is secreted mainly by monocytes/macrophages, neutrophils and endothelial cells. IL-1 consists of two ...
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Cytokines in CAR-T Cell Therapy
What is CAR T-cell therapy? Car-t cell therapy involves genetically engineering T cells isolated from patients or allogeneic donors to express chimeric antigen receptors (CAR) that specifically recognize and kill tumor cells. As a "living" drug, CAR-T therapy is very different from traditional drugs. It is a new type of precision targeted therapy for the treatment of tumors. Compared with ...
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Targeting Interleukin-6 Helps to Mitigate the Side Effects of Immunotherapy
Researchers at The University of Texas MD Anderson Cancer Center have identified a new strategy to reduce immune-related adverse events by targeting immunotherapy with the cytokine interleukin-6 (IL-6). The study, published in Cancer Cell, provides evidence for the concept of combining immune checkpoint blockers and cytokine blockers to selectively inhibit inflammatory autoimmune responses. ...
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Characteristics and Applications of Luminex Multiplex Technology
Luminex multiplex assays is a multi-functional, multi-indicator parallel analysis system that organically integrates color-coded beads, laser technology, applied fluidics, the latest high-speed digital signal processor and computer algorithms to create a high degree of specificity and sensitivity for multi-factor detection. It can be widely used in immunoassay, nucleic acid research, enzymatic ...
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Cytokines: The Master Regulators of Immunity and Inflammation
Cytokines are a broad class of tiny proteins that are essential for controlling inflammation and immunological responses. Numerous cell types, including fibroblasts, endothelial cells, immunological cells, and epithelial cells, produce these signaling molecules. Serving as intermediaries, they synchronize various cell functions to elicit the body's defense mechanisms against infections, tissue ...
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Bioaccesible heavy metals‐sediment particles from Reconquista River induce lung inflammation in mice
The Reconquista River (RR), one of the most polluted watercourses in Argentina, receives effluent discharges from heavily industrialized and highly populated settlements. During winter and summer, the floodplain remains dry, producing the oxidation of sulfide and organic matter present in the sediment, making heavy metals more bio‐accessible. Dispersion of this sediment occurs, and thus harmful ...
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Understanding IL-36 Cytokines: Their Role & Potential in Treating Inflammatory Diseases
Introduction to IL-36 Family Twenty years ago, Interleukin 36 (IL-36) was discovered as a member of the IL-1 superfamily. Its gene is located on chromosome 2 in an IL gene cluster, including IL1A - IL1B - IL37 - IL36G - IL36A - IL36B - IL36RN - IL38 - IL1RN, with IL-36 encoding genes transcribed far away from the centromere. There are four known subtypes of IL-36, which have been renamed multiple ...
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Administration of Lactobacillus fermentum KBL375 Causes Taxonomic and Functional Changes in Gut Microbiota Leading to Improvement of Atopic Dermatitis
Abstract Gut microbiota play an important role in immune responses and energy metabolism. In this study, we evaluated whether administration of Lactobacillus fermentum (L. fermentum) KBL375 isolated from healthy Korean feces improves the atopic dermatitis using the house dust mite (Dermatophagoides farinae)-induced atopic dermatitis (AD) mouse model. Administration of L. fermentum KBL375 ...
By KoBioLabs
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Lactobacillus paracasei KBL382 administration attenuates atopic dermatitis by modulating immune response and gut microbiota
ABSTRACT Administration of probiotics has been linked to immune regulation and changes in gut microbiota composition, with effects on atopic dermatitis (AD). In this study, we investigated amelioration of the symptoms of AD using Lactobacillus paracaseiKBL382 isolated from the feces of healthy Koreans. Mice with Dermatophagoides farinaeextract (DFE)-induced AD were fed 1 × 109 CFU ...
By KoBioLabs
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