Cytokine Production Articles & Analysis
19 articles found
Pharmaceutical companies and manufacturers are increasingly required to evaluate the immunotoxic potential of their products to ensure they do not provoke adverse immune reactions. By identifying potential risks early in the development process, companies can make informed decisions and avoid costly setbacks. ...
Customer confirms that GMP-grade cytokines of interest are produced by the same cloning and manufacturing process as research-grade cytokines. ...
FC not only can detect intracellular and extracellular components, but also detect soluble analytes in serum or plasma samples, such as cytokines, drug complexes, or anti-drug antibodies (ADA). FC can perform single-cell analysis at a rate of hundreds to tens of thousands of cells per second. ...
Hematopoiesis: Cytokines regulate the production and maturation of blood cells in the bone marrow. ...
Cytokines in Cytokine Release Syndrome (CRS) CRS, a systemic inflammatory reaction stemming from diverse triggers such as infections, autoimmune inflammation, and medical causes, involves various cytokine classes including inflammatory effectors, initiators, modulators, chemokines, and colony-stimulating factors. ...
When an adjuvant activates PRRs, it triggers a cascade of signaling events leading to the activation of immune cells and the production of cytokines and chemokines. This activation, in turn, leads to the recruitment of immune cells to the site of vaccination, improving the immune response. ...
However, extracting them from samples such as blood is challenging due to low content, low purity, and high cost, which cannot meet market demands. Currently, cytokines are primarily produced through genetic engineering and DNA recombinant technology, enabling large-scale production. ...
IL-36 beta can activate M2-like macrophages and Langerhans cells; in bone marrow dendritic cells, IL-36 stimulation leads to increased production of pro-inflammatory cytokines (such as IL-1β, IL-6, IL-12, IL-23, and TNF), which may drive innate and adaptive immune responses. IL-36R is mainly expressed on naive CD4 + T cells, promoting differentiation into ...
Customer confirms that GMP-grade cytokines of interest are produced by the same cloning and manufacturing process as research-grade cytokines. ...
This conditioning regimen may improve the proliferation and durable viability of adoptive T cells in vivo by balancing cytokine production in vivo and removing some immunosuppressive cells (such as regulatory T cells and myeloid-derived suppressor cells) in vivo. ...
ImmTAC promotes T cell-mediated effector function by secreting multiple cytokines exhibiting multifunctional responses, such as TNF-α, IFN-γ, IL-6, MIP1α-β, and IFN-γ-inducible protein10. ...
Tumor Necrosis Factor Alpha (TNF-a) is a potent cytokine that is over-expressed by cells during chronic intestinal inflammation. Furthermore, TNF-a represents the most validated clinical target for ulcerative colitis (UC) and inflammatory bowel diseases (IBD) with multiple emerging neutralizing/inflammation-reducing therapeutics targeting this cytokine for ...
SFC is enabling automation of healthcare and remote professional monitoring into its product for better patient care during the times of major upheaval. ...
Oral administration ofL. paracasei KBL382 significantly reduced AD-associated skin lesions, epidermal thickening, serum levels of immunoglobulin E, and immune cell infiltration.L. paracasei KBL382-treated mice showed decreased production of T helper (Th)1-, Th2-, and Th17-type cytokines, including thymic stromal lymphopoietin, thymus, and activation-regulated ...
The isolated cells were characterized with respect to viability, growth kinetics, cytokine production, and phenotype. 3D bioprinted liver tissue was generated using either NPCs isolated from diseased donors combined with non-diseased hepatocytes, or hepatocytes isolated from diseased donors combined with non-diseased NPCs. 3D bioprinted liver tissue generated ...
Naïve and differentiated Orai1–/– T cells showed substantial reductions in store-operated Ca2+ entry, CRAC currents, and cytokine production. These features are consistent with the severe combined immunodeficiency and mild extraimmunological symptoms observed in a patient with a missense mutation in human ORAI1 and distinguish the ORAI1-null mice described here ...
Controlled, transient cytokine production by monocytes depends heavily upon rapid mRNA degradation, conferred by 3' untranslated region-localized AU-rich elements (AREs) that associate with RNA-binding proteins. ...
We aimed to assess the function of polysaccharide moiety of the cell wall of Lactobacillus casei strain Shirota as a possible immune modulator which regulates cytokine production by macrophages. A gene survey of the genome sequence of L. casei Shirota hunted down a unique cluster of 10 genes, most of whose predicted amino acid sequences had similarities to ...
As expected, three patients died and the clinical manifestations were improved in the other patients. The production of cytokines (TNF-, IL-6, and IL-10) by monocytes of patients with tetramine poisoning was much lower than normal controls (P<0.001), and was significantly increased after HP and CVVH in the survivors (TNF-, IL-6, IL-10, P<0.05, P<0.01, P<0.05, ...