Disease Mechanisms Articles & Analysis: Older
38 articles found
Stable cell lines are an indispensable tool in the realm of biomedical research, playing a crucial role in advancing our understanding of cellular processes and disease mechanisms. Unlike primary cells that have a limited lifespan, stable cell lines offer a consistent and renewable source of cells, making them invaluable for long-term studies and industrial ...
In the quest to unravel the complexities of infectious diseases, understanding the intricate interplay between pathogens and their hosts is paramount. ...
This mimetic action allows researchers to enhance or restore the expression of target genes that are otherwise downregulated in diseases such as cancer, neurodegenerative disorders, and cardiovascular diseases. ...
Precision-Cut Lung Slices (PCLS) have emerged as a innovative ex vivo model that allows researchers to explore deep into lung physiology, disease mechanisms, and pharmacological responses. By offering a unique combination of biological complexity and controlled experimental conditions, PCLS serve as a critical bridge between the limitations of traditional in ...
Observing such differential expression is crucial for understanding cellular physiology and disease mechanisms. For example, some proteins may be upregulated or downregulated in health and disease states, or between normal and treated cells.Detection MethodsThe most commonly used technique is mass spectrometry, particularly liquid ...
Signal Transduction ResearchBy detecting the phosphorylation level of specific proteins, the intracellular signal transduction pathways can be studied.2. Disease Mechanism ResearchProtein phosphorylation plays crucial roles in many diseases, including cancer, neurodegenerative diseases, and cardiovascular ...
The ability to immortalize cells that were previously resistant to traditional methods opens up new avenues for studying complex biological processes, disease mechanisms, and therapeutic interventions. Creative Bioarray's Epigenetic Induction of Cell Growth service represents a paradigm shift in cell immortalization technology. ...
This knowledge is vital when developing therapeutics, such as vaccines, or studying disease progression and drug resistance. Clonality analysis services also play a central role in quality control in biotechnology. ...
This technique allows for precise manipulation of the cytoskeleton, providing insights into its role in cellular functions and disease mechanisms. Applications: Functional Studies: Creating knockout models to study the roles of specific cytoskeletal components. ...
This is of great significance for understanding the normal function of cells and the mechanism of disease occurrence.How to Use Single-Cell Sequencing to Screen ...
Tau protein is a microtubule-associated protein, mainly present in nerve cells, and participates in the stabilization of microtubules. In certain neurodegenerative diseases, such as Alzheimer's disease (AD), Tau protein may undergo abnormal phosphorylation and aggregation, forming so-called Tau tangles or neurofibrillary tangles.Ubiquitination is a kind of ...
These post-translational modifications are not only vital for cell function, but their abnormal changes are also associated with cancer, neurodegenerative diseases, and other pathological conditions. Therefore, research on histone PTMs can help to deepen our understanding of disease mechanisms and develop new therapeutic strategies. ...
At the heart of this endeavor lies the art of drug design - the strategic and methodical approach to creating molecules that can effectively target and modulate biological pathways to treat disease. One of the primary strategies in drug design is known as de novo design. ...
MMP-2 and MMP-9 play a role in chronic kidney disease. MMP-9 has also been proposed as a therapeutic target for Alzheimer's disease and type 2 diabetes. ...
By utilizing a panel of stable cell lines, researchers can systematically investigate the impact of gene activation on various cellular processes, identifying potential therapeutic targets or biomarkers for disease. Furthermore, CRISPRa stable cell lines provide a platform for studying the functional consequences of genetic variants or mutations associated with human ...
Drug Discovery and Development: Due to their ability to provide real-time and highly visible readouts, reporter lentiviral systems play a critical role in drug efficacy and toxicology studies. Understanding Disease Pathways: As they enable the visualisation of biological processes in cells, reporter lentiviruses are instrumental in studying disease progression ...
This knowledge is crucial for understanding cell signaling, immune responses, and disease mechanisms. By screening a diverse library of glycans against a protein of interest, researchers can identify the specific glycan structure that bind to the protein, providing insights into its function and potential therapeutic targets. ...
Rare diseases, also known as orphan diseases, are a diverse group of disorders that affect a small percentage of the population. ...
This knowledge is vital when developing therapeutics, such as vaccines, or studying disease progression and drug resistance. Clonality analysis services also play a central role in quality control in biotechnology. ...
These models facilitate the study of disease pathology, identifying underlying mechanisms, and developing potential treatments. ...