disease severity Articles
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Bachelor star Kelley Flanagan endorses IGeneX!
The lovely and talented former star of hit TV show The Bachelor is partnering with IGeneX to raise awareness for Lyme disease. The partnership arose organically, following Kelley’s Lyme disease diagnoses through IGeneX testing in 2021. The two have joined forces leading up to Lyme Awareness Month to bring attention to a critical second pandemic- Lyme and tick-borne disease- encouraging ...
By IGeneX
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High Frequency Jet Ventilation (HFJV) In Mature Infants With NonHomogeneous Lung Disease And Severe Gas Trapping
Infants with gas trapping are difficult to manage with conventional ventilation (CMV). HFJV has been used successfully in infants with severe gas trapping. The techniques used during HFJV in this situation are often described as a "low volume strategy". However, there is little published data to indicate optimal ventilator settings, both Jet and conventional, to achieve these aims. During HFJV ...
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A dual-antigen self-amplifying RNA SARS-CoV-2 vaccine induces potent humoral and cellular immune responses and protects against SARS-CoV-2 variants through T cell-mediated immunity
Self-amplifying RNA vaccines may induce equivalent or more potent immune responses at lower doses compared to non-repli- cating mRNA vaccines via amplified antigen expression. In this paper, we demonstrate that 1 mg of an LNP-formulated dual- antigen self-amplifying RNA vaccine (ZIP1642), encoding both the S-RBD and N antigen, elicits considerably higher neutral- izing antibody titers against ...
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02, 2020 Coronavirus Disease (Covid-19) Outbreak: Rights, Roles and Responsibilities of Health Workers, Including Key Considerations for Occupational Safety and Health
Coronaviruses are a group of viruses belonging to the family of Coronaviridae, which infect both animals and humans. Human coronaviruses can cause mild disease similar to a common cold, while others cause more severe disease (such as MERS – Middle East Respiratory Syndrome and SARS – Severe Acute Respiratory Syndrome). A new coronavirus that previously has not been identified in ...
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Omicron and Covid-19 Testing: What Healthcare Providers Need to Know
As the SARS-CoV-2 omicron variant (B.1.1.529) rapidly became the dominant strain in South Africa in late 2021, public health officials around the globe recognized that a new, highly transmissible form of the virus was likely emerging.1,2 However, understanding the specifics of what was different about omicron remained to be seen. Beyond higher transmissibility, questions around disease ...
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Improving Health in Ucayali, Peru: A Multisector and Multilevel Analysis
We review the key determinants of health in Ucayali, Peru, identified by researchers, and, according to these, propose a set of tools to improve health in this area. Women and indigenous peoples are recognized as two vulnerable groups in the region that face greater health risks, and these are the main focus of the development of tools for health improvement. Also, the growing economic ...
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Expression quantitative trait locus mapping of toxoplasma genes reveals multiple mechanisms for strain-specific differences in gene expression
Toxoplasma gondii is an intracellular parasite with a significant impact on human health, especially in cases where individuals are immunocompromised (e.g., due to human immunodeficiency virus/AIDS). In Europe and North America, only a few clonal genotypes appear to be responsible for the vast majority of Toxoplasma infections, and these clonotypes have been intensely studied to identify ...
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What is FGL2?
Inflammation is a series of complex response events produced by the host system to pathogen infection and various tissue injuries. When the inflammatory response continues, it enters the stage of "uncontrollable inflammation", which plays an important role in the occurrence and development of complex diseases such as tumors. Therefore, the key molecular events in the process of ...
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mRNA vaccine for the pregnant produces antibodies that are passed on to the child and remain for at least 6 months
As the COVID-19 pandemic enters its third year, efforts to mitigate the risk of infection remain critical, especially for vulnerable populations. Recently, Andrea Edlow et al. of Massachusetts General Hospital published a study in the journal JAMA entitled "Durability of Anti-Spike Antibodies in Infants After Maternal COVID-19 Vaccination or Natural Infection". The study showed that ...
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Challenging brain diseases continue to demand new, efficient treatment methods
During this spring, the COVID-19 pandemic has dramatically changed every aspect of life. The business environment has changed not to mention the healthcare sector where the very foundations have been tested around the world. The news have been filled with corona topics and at times the pandemic has seemed to hide other alarming issues: for example, it has been reported in the US that ...
By Nexstim Plc
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OCD: an "autoimmune disease"
Obsessive-compulsive disorder (OCD) is a serious and common psychiatric disorder with a prevalence of approximately 1-3% in adults. The onset of OCD has a bimodal age distribution, usually manifesting first in late childhood and early adolescence and later appearing in early adulthood. OCD is a multifactorial disorder with an interplay of biological, psychological, and external factors, and ...
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An in vitro evidence for caffeic acid, rosmarinic acid and trans cinnamic acid as a skin protectant against γ-radiation
Ionising radiation (γ or X-rays) is the mandatory tool to treat cancer despite its detrimental effects in particular on skin cells which lead to severe dermatological diseases and carcinogenesis. Natural antioxidants caffeic acid (CA), rosmarinic acid (RA), trans cinnamic acid (TCA), p -coumaric acid (PCA), and hydroxyphenyllactic acid (HPA) acid are known to be potent anticancer and ...
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Scientists Find Smart Human Antibody Neutralizes Ebola and Its Deadly Relatives
A research team's latest study shows that two human antibodies can simultaneously target two Ebola viruses: Ebola and Sudan. These two species have caused the largest and deadliest outbreaks. The new report suggests that researchers could combine these two potent antibodies to create an effective antiviral therapy. The work is published in Cell in the paper, “Asymmetric and ...
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`Facial Masking for Covid-19 — Potential for “Variolation” as We Await a Vaccine`
A new theory proposed by infectious disease specialists at UC San Francisco Dr. Monica Gandhi and Dr. George Rutherford in the New England Journal of Medicine claims that if you are infected with COVID-19 through a mask, the face covering can limit the severity of your symptoms. They note that masks reduce the number of viral particles in the air, which leads to a lower dose of the virus, if ...
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Enzymes for Disease Diagnosis: An Overview
Enzymes are protein molecules that catalyze chemical reactions in living organisms. They are involved in many metabolic processes and play a critical role in maintaining the health of the body. In recent years, enzymes have been widely used in disease diagnosis, providing a quick and accurate way to detect and monitor diseases. Enzymes for disease diagnosis can be divided into two categories: ...
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Nanostics is Developing and Validating a Simple Blood Test to Predict Severity of COVID-19 Disease in SARS-CoV-2 Positive Patients
Edmonton, Alberta - Nanostics Inc., a diagnostic healthcare company that focuses on developing tests to determine a patient's disease risk, announced today plans to develop and validate ClarityDX COVID-19; a simple blood test to predict the severity of COVID-19 disease in patients. Nanostics, in collaboration with the Canadian BioSample Repository (CBSR) at the University of Alberta and Century ...
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Nuclear factor I-A regulates diverse reactive astrocyte responses after CNS injury
Abstract Reactive astrocytes are associated with every form of neurological injury. Despite their ubiquity, the molecular mechanisms controlling their production and diverse functions remain poorly defined. Because many features of astrocyte development are recapitulated in reactive astrocytes, we investigated the role of nuclear factor I-A (NFIA), a key transcriptional regulator of astrocyte ...
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Runny or stuffy nose in children. What to do?
Just stay calm! We’re here to help you. A stuffy or runny nose is a struggle for the child, and as a result, for the whole family, but it should not be dangerous if you know how to treat it properly. In this article, you will learn what causes a runny/stuffy nose in a baby or infant, and how to relieve the symptoms. Why does a runny/stuffy nose occur? A runny or blocked nose is caused ...
By Nosiboo
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Cytokine Involvement in Inflammatory Immune Disorders
Cytokines, small molecules with potent biological activity, are primarily synthesized by immune and non-immune cells (e.g., vascular endothelial cells, epidermal cells, fibroblasts) in response to stimulation. These signaling molecules form intricate networks that contribute to immune responses, inflammatory reactions, cell proliferation, and growth. Cytokine Dysregulation in Systemic Immune ...
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Advances in siRNA Drug Research
siRNA, with a molecular weight of about 13 kDa, recruits the RNA-induced silencing complex (RISC) to mRNA through base pairing, thereby inhibiting protein translation. The mRNA is targeted for cleavage through the catalysis of the RISC protein Ago2, a member of the Argonaute family. In addition, other Ago proteins (Ago1, Ago3, and Ago4) catalyze endonuclease-mediated degradation of non-specific ...
By BOC Sciences
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