Disease Severity Articles & Analysis
35 articles found
This process aims to infer the metabolic functions of microbial communities, shedding light on their roles in host metabolism and potential disease associations. Several robust tools are available for PMP, including PICRUSt, Tax4Fun, and Piphillin, each offering unique capabilities for predicting functional profiles based on 16S rRNA data. ...
Individuals with reduced bile production or impaired bile flow, such as those with gallbladder disease or liver dysfunction, may benefit from supplementation with ox bile extract powder to improve fat digestion and absorption, potentially alleviating symptoms related to malabsorption and steatorrhea. Additionally, by promoting the excretion of cholesterol, ox bile extract ...
Moreover, TREM1 activation augments the oxidative burst and microbicidal activity of phagocytes, illustrating its role in host defense mechanisms. Implications in Disease The dysregulation of TREM1 has been implicated in an array of inflammatory and infectious diseases. ...
This therapeutic gene, once inside the cell, generates a functional protein to correct or counter the effects of the disease-causing genetic mutation, providing a basis for curing several genetic diseases. ...
GalNAc can bind to the highly expressed sialic acid receptors in the liver and guide the siRNA bound to itself into liver cells, which has good application potential in treating liver-targeted diseases. GalNAc has become a prominent delivery carrier and has been applied to a variety of drugs. Clinical indications for siRNA drugs siRNA drugs are most widely used in oncology and ...
Cytokine Dysregulation in Systemic Immune Diseases The perturbation of immune tolerance leads to disruption in cytokine homeostasis. ...
It is predicted that the N-terminal domain α-helix and several serine residues can form a coiled-coil structure; the carboxy-terminal is composed of 229 amino acids and contains a highly conserved spherical domain-FRED. ...
Enzymes for disease diagnosis can be divided into two categories: those that are produced by the body in response to disease and those that are specific to the disease itself. ...
Abera’s vaccine delivery platform works as a plug-and-play system where known or novel antigens can be engineered onto our delivery platform to create effective, multivalent vaccines that are cost-effective and fast to produce. We actively work together with academia and industry to enable the use of our vaccine delivery platform in design and development of new vaccines. Many of these ...
HFJV has been used successfully in infants with severe gas trapping. The techniques used during HFJV in this situation are often described as a "low volume strategy". ...
Many neurological diseases, including Alzheimer’s disease, can be thought of as continuums, whether the presence and manifestation of the disease are different depending on the stage of the disease. In this article, we provide a high-level overview of the stages in the Alzheimer's disease continuum, with a focus on preclinical Alzheimer’s disease and its importance in patient care and ...
” The Ebolavirus genus has caused more than two dozen human disease outbreaks, each of which was unpredictable in terms of location, timing, scale, and the identity of the causative virus. Six different Ebola viruses are known, with Ebola virus (EBOV), Sudan virus (SUDV), and Bundibugyo virus (BDBV) known to cause more frequent severe ...
And the activation of ab initio synthesis is negatively correlated with prognosis and disease-free survival in several tumor types. This phenotype is mainly due to the upregulation of lipogenesis-related genes at multiple levels of transcriptional, translational and post-translational modifications, and enzymatic activity, as well as the impact on oncogene ...
Supported by these results, we encourage redirecting focus toward the induc- tion of multiple antigen-targeted cell-mediated immunity in addition to neutralizing antibody responses to bypass waning antibody responses and attenuate infectious breakthrough and disease severity of future SARS-CoV-2 ...
” The COVID-19 pandemic demonstrated the criticality of mRNA vaccines as a tool for quickly and effectively battling disease to improve lives around the world.And though several COVID-19 vaccines are now readily available, our work doesn’t stop there. ...
RNA-Seq is capable of annotating structural variants, allele-specific expression, and disease-associated SNPs by analyzing alternative splicing events. Coupled with bioinformatics pipelines, many extracellular RNAs (exRNAs) continue to be found as potential biomarkers. ...
When a child enters daycare and kindergarten, they bring home not only funny stories but also invisible unwanted guests – infectious diseases. Being exposed to people is a necessary and inevitable stage in a child’s life, but also associated with catching various types of infections, unknown to their body so far. ...
ByNosiboo
Although it is not clear how high a titer is needed to fully protect an infant from SARS-CoV-2 infection, we do know that levels of anti-spike protective immunoglobulin G (anti-spike IgG) are associated with protection from severe disease," said study corresponding author Andrea Edlow, MD, Ph.D., a maternal-fetal medicine specialist at Massachusetts General ...
PANDAS has been expanded to involve other diseases (Mycoplasma pneumoniae, Burkholderia spongiformis, Borna disease virus, and toxoplasmosis gondii) in recent years, and the name pediatric acute onset childhood neuropsychiatric syndrome (PANS) has been coined. ...
The lovely and talented former star of hit TV show The Bachelor is partnering with IGeneX to raise awareness for Lyme disease. The partnership arose organically, following Kelley’s Lyme disease diagnoses through IGeneX testing in 2021. The two have joined forces leading up to Lyme Awareness Month to bring attention to a critical second pandemic- Lyme and ...
ByIGeneX