drug discovery research Articles
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bit.bio CEO features in Charles River Laboratories Disruptor series
bit.bio CEO Mark Kotter is featured as part of the Disruptor series from Charles River Laboratories (CRL). The series, created by CRL, celebrates the work of their partners, engaging in meaningful conversation about the current state of human health and future of scientific innovation and its impact. Mark discusses bit.bio's software approach to biology and how human cells that are programmed ...
By bit.bio
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Towards a fourth generation R&D management model-research networks in knowledge management
Research and development (R&D) management is increasingly about managing knowledge rather than simply managing its generation. Better management of knowledge is a key success factor for industry competitiveness through continuous innovation. R&D management processes developed in the past, which can be described as the first, second, or third generation models, deal with concepts, techniques and ...
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The Protein Data Bank has Over 200,000 Structures
Structural biology is an important field in drug discovery as it helps researchers understand the three-dimensional structure of proteins and how they interact with other molecules. This knowledge is crucial in developing new drugs as it allows scientists to target specific proteins and understand how they contribute to diseases. One of the most important resources in structural biology is the ...
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Advanced Approaches in Inducible Expression Stable Cell Line Development
Harnessing the power of cell biology, scientists across the globe are perpetually invested in the pursuit of understanding the complexities of cellular mechanisms and their adaptability. One such venture is the creation of Inducible Expression Stable Cell Line (IESCL) development. IESCL signifies a consolidated methodology designed to explore the potentialities of modulated gene expression. This ...
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Decoding the Language of Proteins: Insights from Molecular Dynamics Simulation
Molecular dynamics simulation is a powerful and widely employed computational method that investigates the motion and interactions of molecules under different conditions, revealing the structure, dynamics, and physical-chemical properties of molecules. This article aims to delve into the fundamental principles, applications, and key techniques of molecular dynamics simulation, providing you with ...
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Ion Channel Screening & Profiling: Unlocking a New Dimension in Drug Discovery
In the realm of drug discovery, researchers are constantly striving to unlock new possibilities for the treatment of diseases. One crucial aspect of this endeavor is the understanding and exploration of ion channels - integral membrane proteins that regulate the flow of ions across cell membranes. These channels play a fundamental role in numerous physiological processes and are essential targets ...
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How much do animal models play a role in drug development?
Published by Vijay K Singh and Thomas M Seed on September 3, 2021, in Expert Opinion on Drug Discovery and deals with the necessity of animal models for modern drug research in the direction of animal strains, animal models, requirements, and pathways for developing new drugs. The use of experimental animal models in drug development aids in the understanding of disease and/or related conditions' ...
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Decoding the Secrets of Post-Translational Modifications: Unveiling the Power of PTM Predictions
Post-translational modifications (PTMs) are essential chemical alterations that occur on proteins after their synthesis. These modifications play a crucial role in regulating protein function, cellular signaling, and overall biological processes. To unravel the mysteries of PTMs and understand their functional implications, scientists have developed PTM prediction tools that utilize computational ...
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The Key Factor of Excellent Drug Efficacy: Chemical Structure of Drug
How to keep the drug active and give full play to its therapeutic effect has always been the primary problem to be solved by researchers in the field of pharmacy. It is a very complex process from drug administration to the generation of drug efficacy. Scientists have divided this process into three phases: Pharmaceutical phase, pharmacokinetic phase and pharmacodynamic phase. Only by ensuring ...
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90 Days as a Recursionaut
Throughout my career, I always heard about finding your “dream job” but had honestly dubbed the concept a myth. I never imagined that one day, that myth would become my reality. On April 5th, 2021 my now-manager Ben Sukow called with a job offer that changed my perspective. For almost a decade, I have wanted to work in the field of computational biology. I wanted to learn and grow ...
By Recursion
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Unraveling the Complexity of Glycans: Exploring Glycan Arrays and Their Applications
Introduction Glycans, also known as carbohydrates, are complex molecules that play a crucial role in various biological processes. They are involved in cell signaling, immune responses, and cell adhesion, among other functions. Glycan arrays have emerged as powerful tools for studying the interactions between glycans and other molecules. In this blog post, we will delve into the world of glycan ...
By CD BioGlyco.
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A Closer Look at Reporter Lentiviral Particles: Tool for Biomedical Research
Introduction For years, scientists have leveraged the brilliant potentialities of genetic science to explore how cells function and interact in living organisms. Among the numerous tools employed are "reporter systems," which use a visible marker to track gene expression, protein interactions, and other vital biological processes. One such system employs reporter lentiviral particles, using the ...
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Understanding Drug-Disease Relationship Analysis: A Key to Drug Discovery
In the realm of modern medicine, the quest for new and effective drugs to combat various diseases is a continuous journey. Drug discovery, the process of identifying compounds that can potentially treat diseases, has seen a significant transformation in recent years, thanks to advancements in computational biology and artificial intelligence (AI). In this article, we will delve into the ...
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bit.bio CEO featured in Technology Networks
Technology Networks interviews Dr. Mark Kotter, CEO of bit.bio. The interview digs deep into how bit.bio’s next generation cellular reprogramming technology, opti-ox™, is enabling scientists in research and drug discovery to overcome the shared challenges presented by human muscle models. Mark explains how pioneering work conducted in the 1980’s sparked the development of ...
By bit.bio
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Protein-DNA Docking in Drug Discovery: Identifying Small Molecules for New Drug Development
Protein-DNA docking is a complex and critical technique used in the field of structural biology. It involves the study of the three-dimensional structure of biological macromolecules, which play vital roles in many biological processes such as transcription, replication, and DNA repair. Protein-DNA docking allows researchers to predict how proteins and DNA interact with each other, providing ...
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What Are Sphingolipids?
Structure and metabolism of sphingolipids Recently, more than 300 species of sphingolipids have been identified and characterized as long-chain sheath-like base backbones. Ceramide is the aminoacylation product of sphingosine at the 2-carbon position, which has strong biological activity and is a basic structural unit of sphingolipids. The simplest forms of sphingolipids include phosphoceramides ...
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A Commitment to Standards
An Interview with Philip Piqueira, Global Standards Leader for GE’s Industrial Solutions Business General Electric participates in standards development through its work on numerous committees and organizations. Philip Piqueira discusses why this business strategy and its continuance is crucial for GE. From your perspective as the global standards leader for General Electric’s ...
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A Primer in Biological Data Analysis and Visualization
With the development of next-generation sequencing (NGS) technologies and new sequencers, the exponential growth of biological information generated by the scientific community has brought benefits as well as new challenges to researchers. In the era of big data, the field of bioinformatics has made significant progress in the analysis and interpretation of biological data. Therefore, there is a ...
By CD Genomics
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