drug industry Articles
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A 5-minute Screening Method for Incoming Raw Materials in Pharmaceutical Manufacturing
Normal quality control procedures involve accepting a “lot” of a raw material from a supplier and then performing a series of tests to determine if the material is suitable for use in a manufacturing process. For the drug manufacturing industry, as well as many others, this is both a critical and time-consuming (and occasionally costly) step in the process. If the sample is not ...
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The changing role of technology suppliers in the pharmaceutical industry: the case of drug delivery companies
In this paper, preliminary results of a research project on strategies of drug delivery companies (DDC) are presented to discuss the changing role of technology suppliers in the pharmaceutical industry. Changes in the pharmaceutical industry are presented briefly and related to developments in the drug delivery industry. The early observations are contrasted with existing views from the ...
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Micro Flow Imaging Technology for Parenteral Applications
MFI™ for Parenteral Drugs USP Chapter 788 (Particulate Matter in Injections) describes physical tests to be performed for the purpose of enumerating subvisible particles within specific size ranges. Recently the FDA has published a Stimuli Article (reference USPC 30 (6) Pages 2272-2280) demonstrating that advances in apparatus and quality control merit reducing the permissible particle ...
By WIS Biomed
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How to Calculate the Excited State
Due to the bondage of the electric field of the nucleus, electrons in atoms, ions, or molecules generally have many different energy levels. When at the lowest possible energy level, the electrons in these molecules are in the ground state, and when at a higher energy level, these electrons are transferred to the excited state. As the electron grows from the ground state to the excited state, the ...
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Genomics-based drug innovation: visions and commercial viability
This paper tracks the development of genomics between 1990 and 2005 principally within the US context and reviews that development with specific respect to early expectations of genomics-based pharmaceutical innovation, the initial claims made for it, and the realities of its current position. Emphasis is placed on relations between the genomics sector and its larger pharmaceutical and ...
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Charles River Partners with Fios Genomics to Provide Bioinformatics Data Analysis Services - Case Study
As the complexity of advanced therapies continues to grow, more data is needed to establish a drug’s mode of action, efficacy, and long-term safety. It’s no wonder, then, that big data is fueling the drive for tomorrow’s therapies. However, most developers lack the in-house capabilities to produce it and/or the expertise to evaluate it. Charles River has created a complete ...
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Characterization of three classes of membrane proteins involved in fungal azole resistance by functional hyperexpression in saccharomyces cerevisiae
The study of eukaryotic membrane proteins has been hampered by a paucity of systems that achieve consistent high-level functional protein expression. We report the use of a modified membrane protein hyperexpression system to characterize three classes of fungal membrane proteins (ABC transporters Pdr5p, CaCdr1p, CaCdr2p, CgCdr1p, CgPdh1p, CkAbc1p, and CneMdr1p, the major facilitator superfamily ...
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A Computer Scientist`s Quest for Meaningful Work
I was born in a country at the intersection of Europe and the Middle East — both geographically and culturally. Turkey is a beautiful country, and also a challenging one in many aspects. My mom was not able to continue her education after fifth grade because the middle school for girls was miles away from her home. She has always been a big supporter of my education and career. Growing ...
By Recursion
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The Spark for Decoding Biology: An Origin Story
Recursion is entering an exciting period in our evolution as a clinical-stage biotechnology company. We recently announced that we’ve enrolled the first patient in the first human efficacy trial in our company’s history — a significant milestone for us, and for the patients we hope to serve. Our Phase 2 trial is investigating the treatment of a disease called cerebral ...
By Recursion
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Computer Vision-Based Digital Biomarkers Could Enable Faster and More Accurate In Vivo Assessment of Disease
At Recursion, we are working to decode biology and industrialize drug discovery. We have successfully executed over 82 million phenomic experiments and inferred over 179 billion biological relationships in our quest to identify promising novel therapeutic approaches. Now, we are extending our industrialized approach to petabytes of pre-clinical in vivo studies. Digitalizing in vivo studies ...
By Recursion
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Challenges to improving access to essential drugs: perspectives from across the divide
This paper examines the principal challenges to improving the accessibility to healthcare and medicines in developing countries. The analysis draws on current literature to provide an overview of the factors that have led to the disparity in healthcare access; the problems of developing nations in overcoming such impediments and the challenges faced by the providers of medicines, namely that of ...
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Virtual Screening: Revolutionizing Drug Discovery through Computational Intelligence
In the fast-paced realm of drug discovery, scientists constantly seek innovative approaches to efficiently and cost-effectively identify potential drug candidates. Virtual screening, a breakthrough computational technique, is poised to transform the pharmaceutical industry. In this article, we delve into the world of virtual screening and explore its remarkable potential to revolutionize drug ...
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From Black Box to Transparency: Pulling the Curtain Back on Machine Learning
The introduction of Good Machine Learning Practices (GMLP) and increasing buzz around the need for transparency and standardization of machine learning (ML) are significant steps to encourage adoption and trust in these tools across the healthcare industry. To do so, though, requires shifting these ideals from mere concepts into actionable processes without setting an unrealistic bar for ...
By AiCure
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Explosive Growth in Alcohol-Based Hand Sanitizer Production
Overview On January 31, 2020, the Secretary of Health and Human Services (“HHS”) declared a public health emergency related to the COVID-19 pandemic. Shortly thereafter, hand sanitizer began to disappear from U.S. retailers’ shelves, as anxious consumers (and, unfortunately, opportunistic hoarders and resellers as well) swept up all available stock. In the ensuing months, ...
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How Cloud QMS Simplifies Process Validation
Manufacturers who follow the CGMP regulations such as the pharmaceutical manufacturers need to perform process validation to ensure that all the drugs and medicinal products produced meet the quality standards as defined under 21 CFR 211.100(a) and 211.110(a). The validation cannot be effectively performed with a paper-based quality management system anymore especially when your quality teams ...
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What does the environment have to do with diseases that affect the immune system?
The rise in recent decades of diseases such as inflammatory bowel disease and rheumatoid arthritis suggests that factors in the environment are contributing. In 1932, New York gastroenterologist Burrill Crohn described an unusual disease in 14 adults. The patients had bouts of abdominal pain, bloody diarrhea, and lesions and scars on the bowel wall. Doctors in other parts of North America and ...
By Ensia
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Newly Released FDA Guidelines for Sepsis Detection & what it Means for Hospitals
Executive Brief On September 28, 2022, the FDA released Clinical Decision Support, Guidance for Industry and Food and Drug Administration Staff. This guidance is long overdue, and with it comes the elimination of any protections for EHRs, or any other vendors, to pretend it’s OK to sell or deploy solutions for patient monitoring and care for life-threatening conditions like sepsis, that ...
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