Drug Product Development Articles & Analysis
294 articles found
In preclinical respiratory studies, traditional methods like plethysmography often require animal restraint and extensive acclimation, limiting their ability to capture dynamic respiratory changes. To overcome these challenges, IPS Therapeutique Inc. validated a novel telemetry-based technique for continuous monitoring of intrapleural pressure and respiratory patterns in conscious, freely ...
In biotechnology and agriculture, analyzing sterols can help in developing new drugs or engineering more resilient crops. Therefore, a robust Sterol Lipids Analysis service is an indispensable tool for researchers, clinicians, and drug developers. ...
Virus-like particles (VLPs) have garnered significant attention in recent years for their potential applications in vaccine development, drug delivery, and as tools in various biotechnological fields. ...
These helper plasmids typically encode proteins that facilitate the production of the viral envelope and structural proteins. Virus Harvesting: After a designated culture period, the supernatant containing the newly formed lentiviral particles is collected. ...
Whether it is medical research or drug manufacturing, tablet press is a vital link. Let's see how to choose the one that suits you best.Grand pack.The field of drug delivery is constantly evolving, driven by the core goal of improving therapeutic outcomes—enhancing efficacy, reducing toxicity, boosting patient compliance, and even enabling entirely new medical treatments. The global drug delivery ...
Introduction PEGylation, the process of attaching polyethylene glycol (PEG) chains to therapeutic molecules, has become a cornerstone in pharmaceutical development. This technique improves the pharmacokinetic and pharmacodynamic properties of drugs, enhancing their stability, solubility, and circulation time while reducing immunogenicity. Since its first FDA-approved application in 1990 with ...
In this white paper, Predictive Oncology (POAI) highlights a recent successful project in partnership with the University of Michigan Natural Products Discovery Core (NPDC) through the ACE program. The ACE program supports academic researchers in their early drug discovery and development initiatives by providing access to the POAI ...
In the realm of pharmacology and drug development, the assessment of drug permeability is essential. One of the most widely recognized in vitro models for evaluating the intestinal absorption of compounds is the Caco-2 permeability assay. This assay plays a pivotal role in understanding how drugs are absorbed in the gastrointestinal tract and aids in predicting their bioavailability. Background ...
In recent years, the field of antibody drug design has become increasingly significant in the realm of therapeutic development, driven by the need for more effective and targeted treatments for various diseases, including cancer, autoimmune disorders, and infectious diseases. ...
In our last blog, Peter discussed how AI is accelerating the drug discovery process and putting pressure on chemists, who must find ways of developing these potential drugs for subsequent testing or production. ...
ByBUCHI
In recent years, the fight against cancer has seen significant advances, particularly with the emergence of targeted therapy. Among the most promising strategies in this domain is the development of radioactive drug conjugates(RDCs). These innovative therapeutic agents combine the targeting capabilities of antibodies with the cytotoxic effects of radioactive isotopes, providing a powerful ...
Histological image analysis has emerged as a pivotal domain in biomedical research and clinical diagnostics, allowing scientists and healthcare professionals to decipher the intricate structures of tissues at a microscopic level. This analysis encompasses the examination of biological tissues to understand their composition, organization, and pathology, which can be crucial for diagnosing ...
Alfa Cytology has officially released its antibody-drug conjugates(ADCs) development services which demonstrates the dedication to fighting cancer through advanced treatment methods. Alfa Cytology, which stands at the forefront of oncology service provision in New York United States, has announced its sophisticated antibody-drug conjugates(ADCs) development services for cancer. The pioneering ...
Understanding the metabolic stability of potential drug candidates is paramount in the realm of pharmaceutical development. S9 metabolic stability assays provide critical insights into how a compound behaves within biological systems, especially concerning its metabolism, stability, and overall pharmacokinetics. At the core of S9 metabolic stability is the S9 fraction, which is a liver extract ...
The MDCK permeability assay is a critical technique employed in pharmacology and drug development to evaluate the permeability of drug candidates across epithelial cell layers. ...
Development Process Developing an ADC involves several critical stages, including target selection, antibody engineering, linker optimization, and drug loading. ...
Cytokines are small proteins that play a crucial role in cell signaling, particularly in the immune system. They regulate inflammation, immunity, and hematopoiesis, making them essential for understanding various biological processes and disease mechanisms. For researchers working with rabbit models, the ability to accurately measure cytokine levels is vital. This is where Customized Rabbit ...
In the rapidly evolving field of cellular biology and genetic engineering, the development of efficient and reliable cell lines is vital for research and therapeutic applications. ...
In the realm of drug discovery, the search for innovative therapies often leads to new paradigms. One such paradigm that has gained significant traction in recent years is the development of PROTAC (Proteolysis Targeting Chimeras) technology. This groundbreaking approach unlocks new potential in targeting previously “undruggable” proteins, paving the way for transformative therapies ...
Alfa Cytology unveils advanced PD-1 inhibitor development service for cancer research. Alfa Cytology, a prominent service provider in the oncology landscape, has recently launched its innovative PD-1 inhibitor development services. This initiative marks a significant advancement in the quest for more effective cancer therapies, focusing on enhancing precision and adaptability in treatment ...