Drug Safety Articles & Analysis: Older
28 articles found
Pharmacokinetics (PK) and pharmacodynamics (PD) are two fundamental pillars in the field of pharmacology and drug development. Understanding their intricate interplay is essential for determining the efficacy and safety of therapeutic compounds. ...
The world of drug development has long been marked by the rigorous assessment of cardiac safety. ...
Researchers can assess cellular responses to injury and test potential therapeutic agents aimed at promoting healing or preventing scarring. Toxicology and Drug Development: HCEC-12 cells are often utilized to evaluate the cytotoxic effects of various compounds on corneal epithelium. This application is fundamental in the development of ophthalmic drugs and ...
Alfa Cytology has introduced its advanced drug development services for brain tumors. Alfa Cytology, celebrated for its cutting-edge biotech solutions and extensive tumor research expertise, has recently introduced brain tumor drug development services, designed to empower researchers in understanding the intricacies and unique challenges associated with brain ...
Medical advancement relies on clinical trials, which are essential for the development of safe and effective innovative treatments. However, the success and general applicability of these treatments heavily depend on the diversity of the participants involved¹?³. This blog explores the importance of achieving data diversity in clinical trials to enhance clinical trial results and ...
While maintaining a close relationship with PK studies, Toxicokinetic studies primarily square on the adverse effects resulting from drug intake or exposure to a toxic substance. Fundamentally, TK studies provide an understanding of the systemic exposure-risk relation and delivery of safety data for the dose-response analysis. ...
The presence of these impurities can affect the efficacy, safety, and stability of drugs. Therefore, the detection and analysis of glycosylation impurities are crucial in ensuring the quality and therapeutic effectiveness of pharmaceutical products.What are Glycosylated Impurities?Glycosylated impurities refer to a kind of glycosylated product formed during the ...
Drug antibody testing is a laboratory testing method specifically designed to evaluate the immune response of the human body to certain drugs. ...
CD can differentiate the different chiral forms (enantiomers) of drugs, which is critical to ensuring drug safety and efficacy.2. Study of Drug and Target Molecule InteractionsCD can be used to analyze the binding mode of drugs to their biological targets (such as proteins, nucleic acids, etc.). This information ...
Drug development is a complex and multifaceted process that involves extensive research and testing to ensure safety, efficacy and quality for human use. One critical element in the drug development process is drug metabolism and pharmacokinetics (DMPK), which refers to how a drug is absorbed, distributed, ...
The Role of hERG (IKr, Kv11.1) in Drug Safety Due to its sensitivity to inhibition by various drugs, hERG-related cardiotoxicity has become a significant consideration during drug development. Numerous drugs have been withdrawn from the market due to their inadvertent proclivity to block hERG channels, causing ...
Drug development is a complex and multifaceted process that involves extensive research and testing to ensure safety, efficacy and quality for human use. One critical element in the drug development process is drug metabolism and pharmacokinetics (DMPK), which refers to how a drug is absorbed, distributed, ...
Their performance is as follows: (1) Two antigen-binding sites can bind tumor cells and immune cells, redirect immune cells, recruit immune cells to the surroundings of tumor cells, and enhance the killing power of tumors; (2) It can block two different signaling pathways at the same time to enhance cell killing toxicity; (3) Dual antibodies can target tumor cells more specifically, overcome ...
While formulating commonly used preparations, it's vital to examine the compatibility between APIs and excipients to select excipients that do not adversely effects the drug. Solid Dosage Forms Interactions between drug substances and excipients in solid dosage forms involve both physical and chemical interactions. The former can induce changes in the appearance, ...
In the world of pharmaceuticals, developing safe and effective drugs is a complex and time-consuming process. Before a new drug candidate can progress to clinical trials and ultimately reach the market, it needs to undergo rigorous testing in various model systems to assess its efficacy and safety. ...
This technique has emerged as a powerful tool in drug discovery and design. Docking services can be used to identify potential drug candidates, optimize the activity and selectivity of drugs, predict the toxicity of drugs, and design new proteins with specific functions. ...
Cardiovascular safety liabilities caused 52.3 % of 44 marketed data from 1980 to 2011, and cardiovascular disease remains the leading cause of death globally, yet only 8.7% of cardiovascular drugs successfully pass clinical trials. ...
Benefits of forced degradation test The degradation pathway of the drug is closely related to the molecular structure of the drug. The ester group or amide bond in the molecular structure may be hydrolyzed under acid-base catalysis conditions. Provide support for drug safety. When toxicologically relevant impurities are not ...
The purpose of formulation development is to ensure that the drug is safe, effective, stable, and convenient to use. If the dosage form is improperly selected and if the prescription and process design are unreasonable, it will have a certain impact on the quality of the drug product, and even affect the drug’s efficacy and ...
But there are times, when after years of sunk effort and resources, clinical trials fail to bring a viable drug to market. Frequently, a drug fails for safety or efficacy reasons that are beyond a sponsor’s control. However, to some degree, sponsors can control: The speed with which they identify which drugs are viable ...