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Endotoxin Articles & Analysis
11 articles found
The Strategic Role of Downstream Processing The primary objective of downstream development is to separate the product of interest from a complex mixture containing host cell proteins, DNA, endotoxins, aggregates, and media components. Unlike small molecules, biologics are delicate and structurally complex, requiring gentle yet selective purification. ...
Therefore, the cytokines that can be used for its addition must also be animal-free, low endotoxin, and have good stability between batches. That's why GMP-grade cytokines are getting so much attention. ...
Lipopolysaccharides (LPS) are cell wall components of Gram-negative bacteria, also called endotoxins, which are normally confined to the intestinal lumen and are unable to cross the intestinal barrier, but when the intestinal barrier is weakened and an intestinal leak forms, endotoxins can enter the circulation and cause systemic inflammation. ...
In addition, antibody impurities need to be identified and characterized, including product-related impurities (dimers, multimers, degradation products, etc.) and process-related impurities (bacteria, endotoxins, HCPs, host cell DNA, etc.). If the impurity is present, its biological activity needs to be characterized and its potential impact on the in vivo activity of the ADC ...
Signaling through the A2B adenosine receptor dampens endotoxin-induced acute lung injury. J Immunol. (2010) 184:5271–9. doi: 10.4049/jimmunol.0903035 [10] Willingham SB, Ho PY, Hotson A, Hill C, Piccione EC, Hsieh J, et al. ...
Low Endotoxin Cytokines Matters Organoid culture, CAR-T cell therapy, stem cell therapy, and other topics have become broadly discussed among biomedical researchers. ...
Featured Product 1: Recombinant Human IL-2 Product Features: Designed for cellular therapy applications Expressed in E. coli, tag-free Produced using non-animal source materials and pharmaceutical excipients Sterile, free of aminobenzyl penicillin, no HBV, HCV, HIV and other pathogens, mycoplasma-free Endotoxins less than 10EU/mg, host protein residues less than 0.005%, ...
Therefore, the cytokines that can be used for its addition must also be animal-free, low endotoxin, and have good stability between batches. That's why GMP-grade cytokines are getting so much attention. ...
The analysis of intestinal barrier function changes in post-trauma animal models showed that small intestinal DAO activity was negatively correlated with plasma DAO activity, and changes in blood DAO activity reflected intestinal injury, and the changes were correlated with plasma endotoxin levels and bacterial translocation. The stress response produced by intestinal ...
Shape / Format Lyophilized from a 0.2 µm filtered solution of PBS, pH 7.4. Species: Human Endotoxin Fusion label N-8His and N-DYKDDDDK Preparation and storage Lyophilized protein should be stored at ISO certification Manufactured in an ISO 9001: 2015 certified laboratory. ...
MoDC were generated by 6 days of culture in the presence of IL-4 and GM-CSF and were then cultured for 24 or 48 h in medium with lipopolysaccharide (LPS), contact allergens [picrylsulphonic acid (TNBS), 1-chloro-2,4-dinitrobenzene (DNCB)] or irritants [sodium dodecyl sulphate (SDS), benzalkonium chloride (BAC)] that were free of detectable endotoxin contamination. The induction ...