G Protein Coupled Receptors Articles & Analysis
9 articles found
For researchers, CCR1 is more than a seven-transmembrane G protein–coupled receptor (GPCR)—it is a molecular switch that can reshape immune landscapes under stress, infection, or pathological remodeling. ...
Each chemokine binds to a corresponding G-protein-coupled receptor (GPCR), enabling specific cellular responses depending on the receptor-ligand pairing. ...
A pivotal group in this arena is G Protein-Coupled Receptors (GPCRs). These receptors play a crucial role in transmitting signals across cell membranes, significantly influencing numerous physiological processes. ...
Further complexity arises as cancer cells also express the adenosine A1 receptor (ADORA1) and A3 receptor (ADORA3). The binding of adenosine to these receptors triggers tumor cell migration and proliferation through signaling pathways involving Gαi proteins. ...
Why target GPCRs with antibodies? The G Protein-coupled receptor (GPCR) superfamily represents the largest and single most important family of human drug targets. ...
The receptor activates one or more intracellular signaling pathways, involving a series of signaling proteins. ...
Cardiolipids are structurally unique phospholipids located primarily in the inner mitochondrial membrane, where they control mitochondrial respiration and act as a signaling platform in the induction of apoptosis. 3、Protein acylation The abundance and saturation of cellular fatty acids determine the activity of signaling proteins that require acylation ...
There are docking stations called receptors on the surface of our cells. Various compounds ranging from caffeine and dopamine to heroin, tetrahydrocannabinol (THC) and lysergic diethylamine (LSD) all bind to these receptors. Indeed, G protein-coupled receptors are the intended target of action ...
Pituitary adenylate cyclase-activating polypeptide 38 (PACAP38) is a potent neuropeptide that acts through G-protein-coupled receptors. While it is well established that PACAP mediates both neurotrophic and neurodevelopmental effects, the signaling cascades that underlie these diverse actions remain incompletely characterized. ...