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Gastrointestinal Articles & Analysis: This-Year
6 articles found
While effective, oral dosing requires high systematic concentrations, which often lead to gastrointestinal side effects and liver toxicity. A targeted approach that delivers these drugs directly to the lungs offers a transformative ...
Film coatings often use polymers like hydroxypropyl methylcellulose (HPMC) or other enteric coatings to ensure that the drug is released in the desired part of the gastrointestinal tract. Stabilizers: These excipients develop pharmacological formulations' physical and chemical stability. ...
This assay plays a pivotal role in understanding how drugs are absorbed in the gastrointestinal tract and aids in predicting their bioavailability. Background of Caco-2 Cells Caco-2 cells are derived from human colorectal carcinoma and possess characteristics that mimic intestinal epithelial cells. ...
Importance of the MDCK Permeability Assay Drug absorption in the gastrointestinal tract is a significant factor that influences the efficacy of oral medications. ...
· Organoid Disease Modeling – Our models provide a controlled and physiologically relevant setting for studying complex diseases, including cancer, neurological disorders, and gastrointestinal conditions. · Drug Screening & Toxicity Testing – Patient-derived organoids aid in high-throughput drug screening and predictive toxicity evaluations while ...
CH4 production has been linked to slower gastrointestinal motility, contributing to symptoms such as constipation, a common issue in children with IMO. ...