Gastrointestinal Tract Articles & Analysis: Older
29 articles found
The permeability of compounds is evaluated by measuring the transport across this cell monolayer, providing information on how well a drug might be absorbed in the gastrointestinal tract. PAMPA (Parallel Artificial Membrane Permeability Assay): PAMPA utilizes a synthetic membrane to assess the passive diffusion of drugs. ...
Despite its benefits, curcumin has a major drawback: it is poorly absorbed in the gastrointestinal tract and is quickly metabolized by the liver, leading to diminished effects. ...
The reasons include: 1) Protein is easy to denature in acidic gastric juice; 2) Protein is easily degraded by a large number of hydrolytic enzymes in the gastrointestinal tract; 3) Protein is large and polar, so it is not easily absorbed by gastrointestinal epithelial cells through diffusion. ...
Trillions of microorganisms live in the gastrointestinal tract, far outnumbering the body's own cells. The intestinal flora is involved in many physiological and pathological processes in the host, including digestion and absorption of food, metabolism of certain nutrients and pharmaceutical compounds, development of host immunity, intestinal inflammatory states, ...
However, these drugs have various side effects, such as adverse reactions in the gastrointestinal tract and skin, as well as the potential to trigger respiratory and urinary tract infections. ...
The advantages of transdermal patches include sustained release, improved patient adherence, and bypassing the gastrointestinal tract. Nanoparticle Development for Drug Delivery System Nanoparticles have emerged as versatile carriers for drug delivery due to their unique properties, such as high surface area, tunable size, and the ability to encapsulate both ...
However, it poses significant challenges for mRNA delivery due to the susceptibility of mRNA molecules to nucleases and the harsh acidic environment of the gastrointestinal tract. In this regard, researchers at the Georgia State University Center for Diagnostics and Therapeutics prepared LNPs loaded with IL-22 encoding mRNA for oral administration. ...
The gut microbiome consists of trillions of microorganisms, including bacteria, viruses, and fungi, that reside in the gastrointestinal tract. The balance of these microorganisms plays a vital role in regulating the immune system, maintaining gut health, and influencing mental health. ...
In addition, there are many digestive enzymes in the gastrointestinal tract that help digest and absorb nutrients. It can convert food into water-soluble substances, such as sugar into monosaccharides, protein into amino acids, and fat into fatty acids or glycerin, so that the body can absorb use. ...
Product Overview Ingestible, wireless, remote-controlled and powered drug delivery as a capsule Swallowed by patient, traveling through gastrointestinal tract Releases therapeutics at the right place at the right time Relays real-time data to doctors, apps, and mobile devices With 72% of all prescription drugs’ consumption not compliant and $285 ...
BySmartTab
For patients and parents recently affected by or managing short bowel syndrome, TPN is likely new to their vocabulary. While any clinical acronym may sound overwhelming, TPN is not such a complicated one to understand. ...
No parent wants to hear their child has a condition that might affect their education, family life, and overall well-being. Unfortunately, there’s currently no restorative treatment for short bowel syndrome (SBS). Monitoring nutrition is a lifelong necessity for anyone with this disorder. This means that no matter the cause of SBS, there are certain things you should know about nutrition ...
Disintegrant used in disintegration test Disintegrants refer to excipients that promote the rapid disintegration of tablets into small particles in the gastrointestinal tract. Since the drug is compressed into a tablet by a large pressure, the porosity is small and the binding force is very strong. ...
This manifests as keratinization of the lining of the nose, throat, larynx, and other respiratory, gastrointestinal, and genitourinary tracts, weakening the natural barrier against bacterial attack and thus making it susceptible to infection. ...
RT-101 is being evaluated for acromegaly, and Rani expects to run trials for neuroendocrine tumor of the gastrointestinal tract as well as carcinoid syndrome, the CEO said. Imran qualified the market potential for RT-101 in all the three indications as "significant." ...
In addition to the secretion of S-amylase by the salivary glands, it can also be produced by other organs, such as the lungs, sweat glands, breast, gastrointestinal tract, and genitourinary system. In addition, a small number of malignant tumors can also synthesize and secrete S-amylase. ...
There are distinct regions within the gastrointestinal tract, which starts with the mouth and ends with the anus. ...
However, these studies can be lengthy and expensive and may not accurately recapitulate the behavior of the human gastrointestinal tract. Drugs are thus often developed with undesired gut side effects that are not apparent until clinical trials. ...
Abstract Purpose: Limited means exist to assess gastrointestinal activity in pediatric patients postoperatively. Recently, myoelectric gastrointestinal activity recorded by cutaneous patches has been shown in adult patients to be predictive of clinical return of gastrointestinal function postoperatively. The aim of this case series is to demonstrate the feasibility of this system in ...
Antacids work by neutralizing the incredibly caustic acid that can travel backward through your gastrointestinal tract, moving from the stomach into the esophagus, where it burns the lining and causes heartburn. ...