gastrointestinal tract Articles
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Impact of luxs and suppressor mutations on the gastrointestinal transit of lactobacillus rhamnosus GG
It is generally believed that probiotic bacteria need to survive gastrointestinal transit to exert a health-promoting effect. In this study, a genuine luxS mutant and a luxS mutant containing unknown suppressor mutations of the probiotic strain Lactobacillus rhamnosus GG were compared to the wild type for survival and persistence in the murine gastrointestinal tract. The LuxS enzyme, catalyzing ...
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Nanoparticulate systems for oral drug delivery to the colon
A review of oral drug delivery to the colon is a difficult but desirable method of administration. In order to target the colon the dosage form must overcome the barriers presented by the gastrointestinal tract including the steep pH gradient, binding to the mucus layer, premature clearance, and premature cellular uptake. Nanoparticles have been fabricated via a number of methods and designed ...
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Mucus barrier, mucins and gut microbiota: the expected slimy partners?
ABSTRACT The gastrointestinal tract is often considered as a key organ involved in the digestion of food and providing nutrients to the body for proper maintenance. However, this system is composed of organs that are extremely complex. Among the different parts, the intestine is viewed as an incredible surface of contact with the environment and is colonised by hundreds of trillions of gut ...
By A-Mansia
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Analysis of the genome sequence of lactobacillus gasseri atcc 33323 reveals the molecular basis of an autochthonous intestinal organism
This study presents the complete genome sequence of Lactobacillus gasseri ATCC 33323, a neotype strain of human origin and a native species found commonly in the gastrointestinal tracts of neonates and adults. The plasmid-free genome was 1,894,360 bp in size and predicted to encode 1,810 genes. The GC content was 35.3%, similar to the GC content of its closest relatives, L. johnsonii NCC 533 ...
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An in vitro method for determining the bioaccessibility of pharmaceuticals in wildlife
Wildlife can be exposed to human pharmaceuticals via prey that have accumulated the compounds from wastewater, surface water, sediment and soil. One factor affecting internal absorption of pharmaceuticals is bioaccessibility, the proportion of the compound that enters solution in the gastrointestinal tract. Currently, the bioaccessibility of most pharmaceuticals in prey remains unknown for ...
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Protection of gastrointestinal and haematopoietic systems by ascorbic acid-2-glucoside in mice exposed to whole-body gamma radiation
Whole-body exposure of mice to gamma radiation leads to depletion of tissue antioxidant defence and damages the haematopoietic and gastrointestinal systems in mice. Administration of ascorbic acid-2-glucoside (AsAG) at a dose of 100 mg/kg body weight could prevent the radiation-induced reduction of total White Blood Cell (WBC) count and decrease in bone marrow viability following whole-body ...
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Microencapsulation of bacteriophage felix o1 into chitosan-alginate microspheres for oral delivery
This paper reports the development of microencapsulated bacteriophage Felix O1 for oral delivery using a chitosan-alginate-CaCl2 system. In vitro studies were used to determine the effects of simulated gastric fluid (SGF) and bile salts on the viability of free and encapsulated phage. Free phage Felix O1 was found to be extremely sensitive to acidic environments and was not detectable after a ...
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Cutaneous Patches to Monitor Myoelectric Activity of the Gastrointestinal Tract in Postoperative Pediatric Patients
Abstract Purpose: Limited means exist to assess gastrointestinal activity in pediatric patients postoperatively. Recently, myoelectric gastrointestinal activity recorded by cutaneous patches has been shown in adult patients to be predictive of clinical return of gastrointestinal function postoperatively. The aim of this case series is to demonstrate the feasibility of this system in ...
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SmartTab Completes Successful Preclinical Animal Studies for TargetTab™ Platform
SmartTab is pioneering a wireless remote controlled drug delivery system, has completed pre-clinical animal studies and is preparing for human clinical trials for its core technology TargetTab™. This proprietary and patented wireless capsule will revolutionize targeted drug delivery and medicine adherence. DENVER, CO — Prescription pills are often delivered to the wrong site, at ...
By SmartTab
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Mechanism of Action (MOA) of Disintegrant Excipients in Drug Formulation
Disintegration is an early way to evaluate whether a drug is effective. The disintegration time is an important control index for tablets, capsules, and dripping pills. Disintegration means that the solid preparation disintegrates and dissolves or breaks into granules under specified conditions. Except for insoluble coating materials or broken capsule shells, all solid preparations should pass ...
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Broad Application Areas of Cellulase Release Strong Market Demand
Cellulase (β-1,4-glucan-4-glucanohydrolase) is a general term for a group of enzymes that degrade cellulose to produce glucose. Cellulase is a kind of complex enzyme, including C1 enzyme, CX enzyme and glucosidase and other components. Among them, C1 enzyme and CX enzyme can decompose cellulose into cellobiose, and glucosidase can decompose cellobiose into glucose, thereby providing ...
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How Probiotics Help Restore Balance to the Gut Microbiome
Probiotics are living microorganisms that offer numerous health benefits when consumed in adequate amounts. These beneficial bacteria can be found in various fermented foods such as yogurt, kefir, sauerkraut, and kimchi, as well as in dietary supplements. The term "probiotic" is derived from the Greek words "pro" and "biotic," which mean "for life." Probiotics have gained popularity in recent ...
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Antacids, Prescription Drugs or Digestive Enzymes? Your Best Bet for Better Digestion
Upset stomach, heartburn, diarrhea? There are few symptoms as disruptive to your daily life as ones that originate in the digestive system. And if you’re struggling with any of these symptoms, you know exactly how difficult they are to get rid of for good. Doctors recommend a variety of treatments, but there are three biggies they suggest most often for patients who are dealing with both ...
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Understanding Residual DNA Testing and Methods for Detecting Residual DNA
Most biological agents enter the body directly without passing through the gastrointestinal tract, so in addition to biological activity, relevant authorities have very strict requirements on impurities in drugs. Among them, the host cells residual DNA has always been the focus of regulatory agencies because of its special potential safety risks. Although recombinant protein drugs, antibody ...
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The Relationship Between Enzyme Function and Health
In the early 20th century, humans discovered vitamins, and then trace elements and minerals. It was only in the mid-1980s that humans realized the importance of enzymes. Nobel Prize in Physiology and Medicine Arthur Kornberg said: "For our lives, we can no longer find other substances as important as enzymes in nature." Enzymes control the entire body, and when enzymes function abnormally is ...
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8 Health Benefits of Taking Probiotics
Probiotics refer to a certain number of live microorganisms that can have a beneficial effect on the health of the host. At present, there are more than 20 kinds of probiotics used in China, mainly including Bifidobacterium, Lactobacillus, Clostridium butyricum, Saccharomyces boulardii, Enterococcus, Bacillus licheniformis and Bacillus cereus. Probiotics have eight major functions. 1. Maintain ...
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Four Novel Drug Delivery Systems You Should Know
In the field of medicine, effectively delivering drugs to the target site in the body is crucial for successful treatment. Over the years, several innovative drug delivery systems have been developed to improve drug efficacy and patient outcomes. In this article, we will discuss four novel drug delivery systems that have shown promising results in recent research. These systems include ...
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What Are the Health Benefits of Probiotics?
Probiotics are a type of beneficial bacteria that exist in the human gut itself. There are more than 100 trillion bacteria in the human gut, which are roughly divided into beneficial bacteria, intermediate bacteria and harmful bacteria. When the human body is healthy, the intestinal flora is in a balanced state, but when you have symptoms of constipation and diarrhea, it means that the number of ...
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Understanding the Benefits of Probiotic Formula for Gut Health
The gut microbiota, a diverse community of microorganisms residing in our gastrointestinal tract, plays a crucial role in maintaining our overall health. Probiotics, live microorganisms with potential health benefits, have garnered significant attention for their ability to promote gut health. In this article, we will delve into the science behind probiotic formulas, exploring their mechanisms of ...
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Detailed Introduction to the Four Effects of Probiotics
Probiotics, in simple terms, are a group of microorganisms that can effectively promote human health. They can resist gastric acid and bile acid, and can attach and colonize in the intestinal tract. According to statistics, the human gastrointestinal tract contains a rich and diverse microbial community, gathering more than 100 trillion microorganisms. These microbiomes encode more than 3 million ...
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