gut microbiota Articles
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Understanding the Benefits of Probiotic Formula for Gut Health
The gut microbiota, a diverse community of microorganisms residing in our gastrointestinal tract, plays a crucial role in maintaining our overall health. Probiotics, live microorganisms with potential health benefits, have garnered significant attention for their ability to promote gut health. In this article, we will delve into the science behind probiotic formulas, exploring their mechanisms of ...
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Roseburia spp. Abundance Associates with Alcohol Consumption in Humans and Its Administration Ameliorates Alcoholic Fatty Liver in Mice
Highlights The depletion of Roseburia is associated with alcohol consumption in human cohorts R. intestinalis ameliorates the experimental ALD in mice regardless of viability Flagellin from R. intestinalis protects on ethanol-disrupted gut barrier functions The ethanol-induced gut microbiota dysbiosis is restored by R. intestinalis Summary Although a link between the gut microbiota ...
By KoBioLabs
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Microbes4U - Case study
The Microbes4U® study is the first randomized double-blind placebo-controlled pilot study to evaluate the effects of pasteurized Akkermansia muciniphila administered in humans. The main objectives of the Microbes4U® study were to determine the safety, tolerance and metabolic parameters (i.e., insulin resistance, circulating lipids, visceral adiposity, body mass) after 3 months of daily ...
By A-Mansia
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Alleviation of DSS-induced colitis via Lactobacillus acidophilus treatment in mice
Abstract Gut microbiota play a major role in host physiology and immunity. Inflammatory bowel diseases (IBDs), the important immune-related diseases, can occur through immune system malfunction originating due to dysregulation of the gut microbiota. The aim of this study was to investigate the capabilities and mechanisms of Lactobacillus acidophilus (L. acidophilus) KBL402 and KBL409 treatment ...
By KoBioLabs
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Metabolomics in Gut Microbiota Research
With rapid development in sequencing technology, researchers can better assess the effect of the gut microbiome on human health. Human beings have a symbiotic relationship with the microbiota since birth. The environment, proximity to other humans and animals, diet, genetics, and time changes can all affect the microbial composition of our skin, mouth, and intestines. Compared with other ...
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Amplicon Sequencing Technology Unveils the Enigmas of Microbial Populations
Amplicon sequencing is a cutting-edge technique that involves sequencing PCR products or captured fragments of specific lengths, enabling the analysis of sequence variations. Among the diverse applications of this technology, the 16S rRNA gene has emerged as a fundamental tool for sequence-based bacterial analysis, boasting decades of significance. The process of 16S/18S/ITS amplicon sequencing ...
By CD Genomics
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Human Intestinal Ecosystem Analysis
The gut is a complex ecosystem that contains an extremely large community of microbes known as the gut microbiome. The gut microbiome is made up of bacteria, archaea, viruses, fungi, and other eukaryotic microorganisms, including yeasts, flagellates, ciliates, and protozoa. The gut microbiota of a healthy individual consists of six phyla (Firmicutes, Bacteroidetes, Proteobacteria, ...
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A "miracle" fruit that can enhance the immune response to tumors
The advent of immune checkpoint inhibitors (ICI) has improved the overall survival of patients with a variety of malignancies. However, the problem of drug resistance to ICI therapy remains a major obstacle limiting its clinical application. The development of drug resistance is associated with multiple factors, including the level of PD-L1 expression in tumor cells, the tumor microenvironment, ...
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Mucus barrier, mucins and gut microbiota: the expected slimy partners?
ABSTRACT The gastrointestinal tract is often considered as a key organ involved in the digestion of food and providing nutrients to the body for proper maintenance. However, this system is composed of organs that are extremely complex. Among the different parts, the intestine is viewed as an incredible surface of contact with the environment and is colonised by hundreds of trillions of gut ...
By A-Mansia
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Akkermansia muciniphila secretes a glucagon-like peptide-1-inducing protein that improves glucose homeostasis and ameliorates metabolic disease in mice
The gut microbiota, which includes Akkermansia muciniphila, is known to modulate energy metabolism, glucose tolerance, immune system maturation and function in humans1,2,3,4. Although A. muciniphila is correlated with metabolic diseases and its beneficial causal effects were reported on host metabolism5,6,7,8, the molecular mechanisms involved have not been identified. Here, we report thatA. ...
By KoBioLabs
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Exploring the Intricate Link Between Bile Acids and Disease
Bile acids are synthesized in the liver from cholesterol as a raw material. As a natural "emulsifier", they can promote the dissolution, digestion and absorption of fats, fat-soluble vitamins, etc. Meanwhile, as an important signaling molecule, bile acids can activate the relevant receptors to maintain the homeostasis of hepatic glucose and lipid metabolism, and interact with gut bacteria to ...
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Enzymatic Mechanism by Which Dolphin Gut Microbes Degrade Plant Polysaccharides Unveiled
Symbiotic microbial groups within the digestive tract of herbivores are the main source of depolymerized lignocellulases. The dolphin is the largest extant rodent, usually living in the Pantanal wetland and Amazon basin, and is also known as the "king of grass" due to its diet based on grasses and aquatic plants. They can efficiently depolymerize and utilize lignocellulosic biomass through ...
By CD BioGlyco.
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Amplicon Sequencing for Microbiome Research: Introduction, Advantages, and Applications
The identification of microbial groups is an important step in understanding the interrelationship of microorganisms in a community. It is done to determine all present microbial taxa and their relative abundance, and as well their phylogenetic relationships. One of the methods used to establish phylogenetic relationships is by sequencing common genes. One of the easiest genes to be sequenced are ...
By CD Genomics
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Lactobacillus paracasei KBL382 administration attenuates atopic dermatitis by modulating immune response and gut microbiota
ABSTRACT Administration of probiotics has been linked to immune regulation and changes in gut microbiota composition, with effects on atopic dermatitis (AD). In this study, we investigated amelioration of the symptoms of AD using Lactobacillus paracaseiKBL382 isolated from the feces of healthy Koreans. Mice with Dermatophagoides farinaeextract (DFE)-induced AD were fed 1 × 109 CFU ...
By KoBioLabs
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Unleashing the Potential of Bacterial Genome Editing: A Gateway to the Future
Technological advancements and innovative research have continuously led to the discovery and development of new methodologies in the field of biological and medical sciences. One such breakthrough discovery is bacterial genome editing, which opens a new world of opportunities and challenges in the field of biotechnology and genomics. Understanding Bacterial Genome Editing Bacterial genome ...
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Exploring Advanced Industrial Development Services for Probiotics
In the realm of modern health and wellness, the symbiotic relationship between humans and their gut microbiota has taken center stage. Probiotics, or "friendly bacteria," have garnered immense interest for their potential to influence various physiological processes, from digestive health to immune modulation. The expedition of harnessing the therapeutic potential of probiotics is intricately ...
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Administration of Lactobacillus fermentum KBL375 Causes Taxonomic and Functional Changes in Gut Microbiota Leading to Improvement of Atopic Dermatitis
Abstract Gut microbiota play an important role in immune responses and energy metabolism. In this study, we evaluated whether administration of Lactobacillus fermentum (L. fermentum) KBL375 isolated from healthy Korean feces improves the atopic dermatitis using the house dust mite (Dermatophagoides farinae)-induced atopic dermatitis (AD) mouse model. Administration of L. fermentum KBL375 ...
By KoBioLabs
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Detailed Introduction to the Four Effects of Probiotics
Probiotics, in simple terms, are a group of microorganisms that can effectively promote human health. They can resist gastric acid and bile acid, and can attach and colonize in the intestinal tract. According to statistics, the human gastrointestinal tract contains a rich and diverse microbial community, gathering more than 100 trillion microorganisms. These microbiomes encode more than 3 million ...
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The Relationship Between the Gut Microbiome and Drugs Is Greater Than We Thought
Gut microbes are considered "virtual organs" that influence host health and are involved in disease research. The human gut microbiota has a large gene pool, encoding approximately 100-150 times more genes than the human genome, and contains a rich resource of enzymes with the ability to metabolize drugs. The diversity of gut bacteria also affects the mental health of the host. Microbiomes from ...
By CD Genomics
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Distinct signatures of gut microbiome and metabolites associated with significant fibrosis in non-obese NAFLD
Nonalcoholic fatty liver disease (NAFLD) is associated with obesity but also found in non-obese individuals. Gut microbiome profiles of 171 Asians with biopsy-proven NAFLD and 31 non-NAFLD controls are analyzed using 16S rRNA sequencing; an independent Western cohort is used for external validation. Subjects are classified into three subgroups according to histological spectra of NAFLD or ...
By KoBioLabs
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