Hepatic Glucose Articles & Analysis
6 articles found
Meanwhile, as an important signaling molecule, bile acids can activate the relevant receptors to maintain the homeostasis of hepatic glucose and lipid metabolism, and interact with gut bacteria to regulate the development of the intestine and the inflammatory response of the body. ...
Mechanism action of Canagliflozin Canagliflozin is a sodium-glucose cotransporter (SGLT2) inhibitor. Glucose filtered in the renal tubular lumen is mainly reabsorbed by SGLT2 expressed in the proximal renal tubule. By inhibiting SGLT2, cagliegin reduces the renal reabsorption of filtered glucose, lowers renal glucose threshold ...
Introduction Nonalcoholic fatty liver disease (NAFLD) is characterized by hepatic manifestations of metabolic disorders, ranging from simple steatosis to nonalcoholic steatohepatitis (NASH), an aggressive histological form, ultimately leading to advanced fibrosis and cirrhosis. ...
Clamp studies work by varying an infusion of glucose or insulin so that blood glucose concentration is maintained (clamped) at a specific level. This quantifies the reaction to glucose or insulin, (usually how sensitive an individual is to insulin or to how well someone metabolises glucose). ...
Previously, we demonstrated that SRSF3 regulates splicing of the insulin receptor gene (INSR) (8) and plays an important role in hepatocyte differentiation and hepatic glucose and lipid metabolism (9). Furthermore, we have shown that hepatocyte-specific deletion of the SRSF3 gene (SRSF3H-KO) promotes hepatocellular carcinoma (HCC) in aged SRSF3H-KO mice (10, 11), ...
Insulin controls glucose homeostasis and lipid metabolism, and insulin impairment plays a critical role in the pathogenesis of diabetes mellitus. ...