Hormone Receptor Articles & Analysis
8 articles found
Common markers include estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2). ...
The majority of patients with metastatic breast cancer (MBC) have hormone receptor-positive HER2-negative disease. For this subgroup, endocrine therapy is the key therapeutic option. ...
Opportunities * Small molecule degraders, including "molecular gels" and PROTACs, are becoming powerful research tools for the proteome. * Hormone receptors, kinases, and bromodomain are now the most common drug targets for PROTACs, while molecular gels mostly target transcription factors, and the pharmacologically relevant degradable proteome is likely to become ...
Microcystin‐LR (MC‐LR) has the potential to disturb thyroid hormone (TH) homeostasis, but little is known of the underlying mechanisms of MC‐LR in fish. ...
Also, an up‐regulation of hepatic lpl (lipoprotein lipase) and a down‐regulation of ar (androgen receptor) and star (steroidogenic acute regulatory protein) were observed in testes. ...
The incorporation of brominated flame retardants into industrial and household appliances has increased their occurrence in the environment resulting in deleterious effects on wildlife. With the increasing restraints on available compounds there has been a shift to using BFRs that has seen the production of alternative BFRs such as 1,2‐dibromo‐4‐(1,2 dibromoethyl) cyclohexane (TBECH). TBECH ...
The effects of PCP exposure on plasma thyroid hormone levels, and the expression levels of selected genes, were measured in the brain and liver. ...
Reporter gene assays were used to detect receptor‐mediated (anti‐)estrogenic, (anti‐)androgenic, and (anti‐)thyroid hormone activities. ...