human cancer Articles
-
Identification of a posttranslational mechanism for the regulation of herg1 k+ channel expression and herg1 current density in tumor cells
A common feature of tumor cells is the aberrant expression of ion channels on their plasma membrane. The molecular mechanisms regulating ion channel expression in cancer cells are still poorly known. K+ channels that belong to the human ether-a-go-go-related gene 1 (herg1) family are frequently misexpressed in cancer cells compared to their healthy counterparts. We describe here a ...
-
Recovery of low-dose hyper-radiosensitivity following a small priming dose depends on priming dose-rate
T-47D human breast cancer cells were irradiated with 60Co γ-radiation and radiation response was measured by loss of ability of single-cells to form colonies. The influence of the dose-rate on the ability of priming irradiation to abolish Low-Dose Hyper-Radiosensitivity (LDHRS) was investigated. In agreement with previous reports, the LDHRS was abolished by an acute priming dose of 0.3 Gy given 6 ...
-
Study of 6-propyl-2-thiouracil as a radioprotector for the thyroid gland
The objective of the paper was to study the application of 6-propyl-2-thiouracil (PTU) as a radioprotector for the thyroid gland. Rat thyroid epithelial cells (FRTL-5) and human colon cancer cells (ARO81-1) were exposed to γ-irradiation with or without 1 mM PTU. Radiation response was analysed by clonogenic survival assay. Cyclic AMP levels were measured by Radioimmunoassay (RIA). The results ...
-
Poly(propyleneimine) dendrimers as potential siRNA delivery nanocarrier: from structure to function
The goal of the present investigation is to reveal the role of the Poly(propyleneimine) (PPI) dendrimer structure on the siRNA nanoparticles formation, facilitation of cell internalisation, and sequence specific knockdown of targeted genes. It was found that the higher generations of PPI dendrimers (G4 and G5) most effectively initiated the complexation of siRNA into discrete nanoparticles when ...
-
Mapk4 May Be a New Target for the Treatment of Triple-Negative Breast Cancer
There is now growing evidence that the MAPK4 enzyme may be involved in cancer growth and resistance to specific therapies. Recently, an article titled " MAPK4 promotes triple negative breast cancer growth and reduces tumor sensitivity to PI3K blockade" was published in Nature Communications. By analyzing public genome databases, the researchers found that a large number of triple-negative ...
-
Demonstration of radiation-induced bystander effect in a human lung cancer cell line
The purpose of this study was to investigate whether a bystander effect is manifested in a large cell lung tumoural cell line (QU-DB). For induction of a bystander effect in non-irradiated cells the 'medium transfer' technique was employed, and to observe the effect the cytokinesis-block micronucleus assay was applied. Results showed that irradiated and bystander cells demonstrated higher numbers ...
-
Chromosomal aberrations induced by a low dose of neutron irradiation and hyperthermia
The purpose of this study was to investigate the effect of Hyperthermia (HT) on the Frequency of Chromosomal Aberrations (FCA) induced by a low dose of neutron irradiation. Blood samples were exposed to HT, 6cGy neutrons, HT + neutrons and neutrons + HT, and the FCA was scored in metaphase. HT alone at 41.5°C had no effect on FCA; however, the FCA was significantly higher at 43°C (p Keywords: low ...
-
Synthetic lethal kinases in Ras/p53 mutant squamous cell carcinoma
Abstract The oncogene Ras and the tumor suppressor gene p53 are frequently co-mutated in human cancer and mutations in Ras and p53 can cooperate to generate a more malignant cell state. To discover novel druggable targets for cancers carrying co-mutations in Ras and p53, we performed arrayed, kinome focused siRNA and oncology drug phenotypic screening utilizing a set of syngeneic Ras mutant ...
-
Raman ‘optical biopsy’ of human breast cancer
Abstract Raman imaging (RI) is a novel method of medical diagnostics of human breast cancer and has a potential to become a routine optical biopsy. Up to date the present study is the most statistically reliable Raman analysis based on data of normal, benign, and cancerous breast tissues for 146 patients. This paper present the first Raman ‘optical biopsy’ images of the normal and ...
-
Revealing the molecular mechanism of mutant protein-induced melanoma in the body
The RNA surveillance pathway detects and interprets defective transcripts to ensure RNA fidelity. Recently, in a research report entitled "Oncogenic CDK13 mutations impede nuclear RNA surveillance" published in Science, scientists from Howard Hughes Medical Institute and other institutions discovered a new type of mechanism that affects the occurrence of melanoma, providing broad and important ...
-
Abstract 4842: A comparative preclinical study of PARP inhibitors demonstrates superb properties for IDX-1197
Abstract Background PARP inhibitors have demonstrated clinically meaningful increase in progression-free survival as a single agent in women with recurrent ovarian cancer following a response to platinum-based chemotherapy. We aimed to develop a novel PARP inhibitor that may have potent antitumor efficacy. IDX-1197 is a novel, potent, selective, and orally bioavailable poly (ADP-ribose) ...
-
Formaldehyde – a dangerous chemical
It’s amazing all the places that formaldehyde is found. It’s best known uses are in insulating material and particleboard. The most publicized use has been in manufactured homes and mobile homes. FEMA has been overwhelmed with actions related to exposure to formaldehyde in temporary housing for Hurricane Katrina survivors, and other disasters. There are both short term and long ...
-
Cancer incidence in areas with elevated levels of natural radiation
It has been reported that on reaching a certain level of cell damage the production of repair enzymes is triggered which decreases the chromosome aberrations. If this happens, prolonged exposure to high levels of natural radiation in areas with elevated levels of background radiation could decrease the frequency of chromosome aberrations. Recent epidemiological studies indicated that there is an ...
-
Protein Acetylation and Ubiquitination Interactions Control MCL1 Protein Stability
The anti-apoptotic myeloid cell leukemia 1 (MCL1) protein belongs to the BCL2 family that supports survival and is frequently amplified or upregulated in human cancers. MCL1 is highly unstable and its stability is regulated by phosphorylation and ubiquitination. Here, the authors suggest that acetylation is another key post-translational modification that regulates MCL1 protein instability. The ...
-
Evaluation of radioinduced damage and repair capacity in human breast cancer cells, MCF-7 and T-47D
Ionising radiation is an established etiological agent for breast cancer, but is also a therapeutic modality used in cancer treatment. The accumulation of deoxyribonucleic acid (DNA) damage and deficient DNA repair are considered susceptibility factors that predispose individuals to breast cancer development. In the present study, the genetic damage induced by gamma radiation and repair capacity ...
-
Non-cancer disease mortality and risk analysis among medical X-ray workers in China
The non-cancer disease mortality (1950-1995) among 27 011 medical diagnostic X-ray workers was compared to that of 25 782 other medical specialists employed between 1950 and 1980 to provide evidence of human non-cancer disease death produced by protracted and fractionated exposure to ionising radiation and assess the resultant non-cancer disease death risk. The total non-cancer disease mortality ...
-
How the Breuer Lab tracks their sample information at every step of their research
Dr. Eun-Kyoung Breuer is an Assistant Professor and an Associate Director of the Radiobiology Program in the Department of Radiation Oncology at Loyola University Chicago. Her lab's research focuses on understanding the role that tumor suppressor genes play in the DNA damage response pathway and in breast cancer regulation. A centralized information management approach Doing research focuses on ...
-
Raman imaging at biological interfaces: applications in breast cancer diagnosis
Abstract Background: One of the most important areas of Raman medical diagnostics is identification and characterization of cancerous and noncancerous tissues. The methods based on Raman scattering has shown significant potential for probing human breast tissue to provide valuable information for early diagnosis of breast cancer. A vibrational fingerprint from the biological tissue provides ...
-
A Plant Immune Protein May be Expected to Completely Cure Cancer!
Cancer, caused by abnormal cell proliferation, is one of the world's major public health problems. Recently, in a research report entitled "A plant immune protein enables broad antitumor response by rescuing microRNA deficiency" published in Cell, Scientists from institutions such as Peking University have found that a special plant immune protein may achieve a broad spectrum of anti-tumor ...
-
New Technology of PROTACs
Most of the drugs currently in clinical use are based on small molecules and use the "occupancy-driven" mode of action to inhibit the function of proteins and play a role in the treatment of diseases. Different from traditional small molecule inhibitors and antagonists, protein degradation technology has developed rapidly in recent years because of its ability to induce the degradation of ...
Need help finding the right suppliers? Try XPRT Sourcing. Let the XPRTs do the work for you