Human Disease Articles & Analysis: Older
66 articles found
These protein drugs exhibit certain biological activity and can prevent, diagnose, and treat diseases in humans, animals, and plants. Compared with small molecular drugs, recombinant protein drugs offer advantages such as high activity, high specificity, and low toxicity, and are therefore favored by researchers. At present, recombinant protein drugs are widely ...
Researchers can add tags, fluorescent markers, or reporter genes to visualize cellular processes in real-time. Disease Modeling: Knockin cell lines mimic human disease conditions by introducing disease-related genetic mutations, thus offering a robust platform to study pathophysiology and screen potential therapeutic ...
For such critical samples, especially those from diseased human biopsies, high-quality media are required. This reduces the risk of contamination and saves time, labor and money by eliminating required preparation steps and replenishment. ...
These proteins possess certain biological activities and can prevent, treat, and diagnose diseases in humans, animals, and plants. Compared to small molecule drugs, protein drugs have advantages such as high activity, high specificity, and low toxicity, making them highly favored by researchers. Currently, protein drugs are widely used in various fields, ...
It can also be used to study the mechanisms of some diseases, such as cancer, genetic diseases, and infectious diseases.1. Medical ResearchGene knockout is often used in medical research to study human diseases. For example, by knocking out genes associated with diseases, scientists can better ...
Autophagy has also been implicated in pathological conditions including neurodegenerative diseases, cancer, and inflammatory diseases. Modulation of autophagy has become a potential therapeutic target in human diseases. ...
Recently developed CRISPR/Cas9-based screening methods have great potential for revealing the mechanisms and treatment strategies of human diseases, but there are still some biological studies that are not suitable for CRISPR knockout screening. ...
Genomic engineering in cell lines is a versatile tool for studying gene function, designing diseases models, biopharmaceutical research, drug discovery and many other applications. ...
Disturbances in metabolic pathways can lead to many common human diseases such as cancer, diabetes, obesity, hypoglycemia, hypolipidemia, phenylketonuria, neurodegeneration, etc. ...
MMP-2 and MMP-9 play a role in chronic kidney disease. MMP-9 has also been proposed as a therapeutic target for Alzheimer's disease and type 2 diabetes. ...
By utilizing a panel of stable cell lines, researchers can systematically investigate the impact of gene activation on various cellular processes, identifying potential therapeutic targets or biomarkers for disease. Furthermore, CRISPRa stable cell lines provide a platform for studying the functional consequences of genetic variants or mutations associated with ...
Dysbiosis of the intestinal flora is associated with a variety of human metabolic diseases, such as obesity, diabetes mellitus, and nonalcoholic fatty liver disease. ...
However, preclinical animal models have emerged as invaluable resources for advancing research and unraveling the mysteries surrounding rare diseases. Animal models play a critical role in biomedical research, as they allow scientists to study complex disease processes, develop new therapies, and test their safety and efficacy before moving into ...
Biomarkers for the detection of certain metabolic diseases could be methylated DNA, acetylated proteins, miRNA, specific substrates, cofactors, enzymes engaging in biochemical reactions linked to epigenomic procedures in body fluids. Epigenetic alterations induced by microbial invasion Numerous studies have exhibited that specific pathogens (Helicobacter pylori, Streptococcus ...
In vitro models use human cells cultured to mimic COPD conditions and are particularly used for studying the cellular and molecular mechanisms of the disease. ...
In vitro models use human cells cultured to mimic COPD conditions and are particularly used for studying the cellular and molecular mechanisms of the disease. ...
This information can lead to a better understanding of disease mechanisms and help identify novel therapeutic targets. By comparing healthy and diseased tissues, researchers can pinpoint differentially expressed genes and potential therapeutic targets specific to certain cell types or disease states. ...
By conducting cognitive behavioral tests, scientists can better understand the cognitive abilities of different animal species and how they compare to humans. 2. Comparative studies: Comparative cognition research is important for understanding the evolution of cognitive abilities across species. ...
These findings provide valuable insights into utilizing gut microbiota as biomarkers to evaluate the progression of lung cancer and offer potential intervention targets for future disease control strategies. Amplicon Sequencing Assists in Microbial Resistance Research Neonicotinoid insecticides, widely applied to control agricultural insect pests, face challenges due to the ...
Recent studies have also associated ASE with the susceptibility of a number of human diseases. RNA-seq and whole-genome DNA sequencing(WGS) allow identification of common disease variants, including SNPs and ASE. ...