human serum Articles
-
Preparation of human serum albumin nanospheres labelled with 188Re
The aim of this paper is to present a method for the labelling human albumin nanospheres with the short lived beta emitter 188Re. In this method stannous chloride is used as reducing agent and potassium sodium tartrate as transchelation agent. Optimal parameters of the labelling reaction and also, the stability of the radiolabelled nanospheres were established. Under optimal reaction condition, ...
-
Labelling of albumin microspheres with 188Re: a possible agent for radiotherapy
Regional administration of labelled particles by intra-arterial infusion is an effective method for endoradiotherapy of tumours. The goal of the study was to develop an efficient method for radiolabelling of biodegradable human serum albumin microspheres with the beta emitter 188Re. The influence of different factors, as the reagents concentration, temperature, time, etc., on reaction yield was ...
-
Antioxidant therapy and its stability on Chernobyl clean-up workers
This paper describes the effects of prolonged antioxidant therapy, its stability and association with spectral parameters of the fluorescent probe ABM in blood plasma and indices of albumin auto-fluorescence in Chernobyl clean-up workers from Latvia. Patients were divided into two groups. Group 1 received placebos of identical appearance to antioxidants. Group 2 received antioxidants (vitamin E + ...
-
Biochemical and Clinical Applications of Glucose Oxidase (GOD)
Glucose oxidase (GOD) is a typical oxidoreductase found in honey and molds such as Penicillium notatum. It can highly specifically catalyze the β-D-glucose reaction to generate gluconic acid, which has the function of converting glucose and removing oxygen. Since GOD can quantitatively generate hydrogen peroxide, it is widely used in the field of biochemistry and clinical examination as a ...
-
ADC Cleavable Linker : Classification and Mechanism of Action
Antibody-drug conjugates (ADCs), as emerging anticancer drugs, can deliver highly cytotoxic molecules directly to cancer cells to kill them. ADC is a monoclonal antibody covalently bound to cytotoxic chemical substances (payload) through linker. ADC linker plays a key role in the therapeutic effect of ADC, and its characteristics greatly affect the therapeutic index, pharmacodynamics and ...
By BOC Sciences
-
Review of ADC Linker and Research Progress
The linker is not only the molecule part of the covalent link between the antibody and the small molecule payload, but also a key element with design properties in targeted drug therapy. The addition of the linker should not induce aggregation and needs to ensure acceptable PK characteristics, while limiting the premature release of the payload in plasma and enabling the effective release of ...
By BOC Sciences
-
Nanobodies Definition, Structure, Advantages and Applications
What is a Nanobody?Nanobodies are the smallest functional single-domain antibodies known to be able to stably bind to antigens, and have unique structural and functional advantages. The molecular weight of nanobodies is only 12-15 kDa, which retains the antigen binding ability of traditional antibodies. However, nanobodies have higher solubility and stability, and have unique advantages in ...
By BOC Sciences
-
Overcoming Immunological Challenges Limiting Capsid-Mediated Gene Therapy With Machine Learning
A key hurdle to making adeno-associated virus (AAV) capsid mediated gene therapy broadly beneficial to all patients is overcoming pre-existing and therapy-induced immune responses to these vectors. Recent advances in high-throughput DNA synthesis, multiplexing and sequencing technologies have accelerated engineering of improved capsid properties such as production yield, packaging efficiency, ...
-
Recent Advances in ADC Linker
The development of antibody-drug conjugates (ADCs) has progressed significantly over the past decade due to improvements in payloads, linkers, and conjugation methods. In particular, linker design plays a key role in regulating ADC stability in systemic circulation and payload release efficiency in tumors, thereby affecting ADC pharmacokinetics (PK), efficacy, and toxicity profiles. Some key ...
By BOC Sciences
Need help finding the right suppliers? Try XPRT Sourcing. Let the XPRTs do the work for you