Ifn Alpha Articles & Analysis
14 articles found
Introduction PEGylation, the process of attaching polyethylene glycol (PEG) chains to therapeutic molecules, has become a cornerstone in pharmaceutical development. This technique improves the pharmacokinetic and pharmacodynamic properties of drugs, enhancing their stability, solubility, and circulation time while reducing immunogenicity. Since its first FDA-approved application in 1990 with ...
Some of the primary classes include interleukins (IL), interferons (IFN), tumor necrosis factors (TNF), colony-stimulating factors (CSF), chemokines, and growth factors (GF). ...
Type A ODNs, which feature a central palindromic CpG-containing phosphodiester (PO) structure followed by a phosphorothioate (PS) homopolymeric G-stretch, are robust inducers of interferon-α (IFN-α) production and dendritic cell maturation. Type B ODNs, in contrast, contain a full phosphorothioate backbone with one or more CpG ...
Cytokine Classification Cytokines are categorized into various subtypes, including interleukins (IL), interferons (IFN), tumor necrosis factor (TNF), colony-stimulating factor (CSF), chemokines, and growth factors (GF). ...
The use of IL-2 alone, or in combination with other cytokines such as TNF-α or IFN-γ, can increase the cytotoxicity of macrophages. Dendritic cells can express all three subunits of IL-2R. They translocate IL-2R alpha (CD25) to the initial T cells that need to bind with high affinity to IL-2, causing them to differentiate into cells ...
Polyethylene glycol (PEG), a compound composed of repeated ethylene glycol units [-(CH2CH2O)n], is also known as Macrogols. PEG and PEG derivatives have the characteristics of non-irritation, good water solubility, good compatibility, etc. . At the same time, they possess excellent lubricity, moisture retention and dispersibility so that they can be used as adhesives, antistatic agents and ...
Analysis of tissue staining and immunohistochemistry showed that the natural hydrogel significantly accelerated the granulation tissue regeneration, angiogenesis and collagen deposition in chronic wounds, and significantly down-regulate the expression levels of TNF-α, IFN-γ, IL-6 and other inflammatory cytokines in tissues. ...
Vero cellsare a continuous adherent cell line that is frequently used in cell culture and plays an important role in worldwide vaccine and vector production (manufacturing). Unlike other mammalian cells, they do not secrete interferon alpha or beta when infected by viruses – this is one of the reasons that efficient replication of many viruses can be achieved in Vero cells, ...
ByNuvonis
Various immune cells in the body such as macrophages, neutrophils, natural killer cells and dendritic cells can release various cytokines, such as IL-1, IL-2, IL-6, IL-8, IL-10, IL-12, chemokines, granulocyte colony-stimulating factor, granulocyte megakaryocyte colony-stimulating factor, IFN-γ, TNF-α and so on. Through a specific positive feedback ...
TCR-engineered T cells express tumor antigen-specific receptors with alpha and beta chains generated from high-quality, high-affinity clones of antigen-specific T cells. ...
Interleukin-12 (IL-12) IL-12 is the most potent NK cell activator that promotes the differentiation of CD4+ Th0 cells into Th1 cells and stimulates NK and T cells to produce various cytokines such as IFN-γ, IL-2, TNF-α, GM-CSF, IL-3, IL-8, etc., and then acts through these transmitters. ...
Protease formulations are without a doubt one of the most fully functional dietary supplements in terms of providing significant health benefits. Clinical studies have documented numerous effective benefits and support for people facing a variety of health challenges, including: a) Asthma b) Atherosclerosis c) Autoimmune disease d) Bronchitis e) Cancer f) ...
More than 10 types of interferons have been identified and can be classified into alpha, beta and gamma (α, β and γ) types, which are subdivided into different subtypes. α and β interferons are mainly produced by virus-infected cells, while γ interferons are mainly produced by activated T cells and natural ...
Analysis of intestinal bacteria revealed severe dysbiosis in the absence of potent IFN signaling, which triggers expansion of TH17 cells and loss of splenic Treg cells. ...