in vitro biotransformation Articles
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TOWARDS IMPROVED MODELS FOR PREDICTING BIOCONCENTRATION OF WELL‐METABOLIZED COMPOUNDS BY RAINBOW TROUT USING MEASURED RATES OF IN VITRO INTRINSIC CLEARANCE
Models were developed to predict the bioconcentration of well‐metabolized chemicals by rainbow trout. The models employ intrinsic clearance data from in vitro studies with liver S9 fractions or isolated hepatocytes to estimate a liver clearance rate which is extrapolated to a whole‐body biotransformation rate constant (kMET). Estimated kMET values are then used as inputs to a mass‐balance ...
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Somatic and gastro‐intestinal in vivo biotransformation rates of hydrophobic chemicals in fish
To improve current bioaccumulation assessment methods, a methodology is developed, applied and investigated for measuring in vivo biotransformation rates of hydrophobic organic substances in the body (soma) and gastro‐intestinal tract of the fish. The method resembles the bioaccumulation OECD 305 dietary test but includes reference chemicals to determine both somatic and gastro‐intestinal ...
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