In Vivo Assays Articles & Analysis
10 articles found
These tests include the study of pharmacokinetics, drug interaction potentials, metabolic stability, metabolite identification, and more. Although in vivo assays provide more comprehensive information, in vitro DMPK studies are less expensive, have shorter turnaround times, and are considered more ethical as they reduce animal usage in pharmaceutical research. ...
These tests include the study of pharmacokinetics, drug interaction potentials, metabolic stability, metabolite identification, and more. Although in vivo assays provide more comprehensive information, in vitro DMPK studies are less expensive, have shorter turnaround times, and are considered more ethical as they reduce animal usage in pharmaceutical research. ...
The Clinical CRISPR Successes Are Stacking Up. But Where’s the Emphasis on Quality Control? In mid-September, Intellia released some promising data on two of their CRISPR-based therapeutics. These results are a significant milestone for genome editing and validation of its effectiveness in the clinic. However, the safety of CRISPR-based therapeutics has been a major concern and part of a ...
Compounds are required to be characterized thoroughly for ADME properties prior to regulatory approval, and during preclinical drug discovery/development act as key attributes that can determine the compound’s prioritization for further testing1.Thestandard in vivo assay for ADME characterization is the measurement of plasma concentrations over time after ...
The US Environmental Protection Agency has responsibility for assessing endocrine activity of more than 10 000 chemicals, a task that cannot reasonably be achieved solely through use of available mammalian and nonmammalian in vivo screening assays. Hence, it has been proposed that chemicals be prioritized for in vivo testing using data from in ...
Coumarin derivative anticoagulant rodenticides used for rodent control are posing a serious risk to wild bird populations. For warfarin (WF) a classic coumarin derivative, chicken have a high LD50 while mammalian species generally have much lower LD50. Large interspecies differences in sensitivity to WF are to be expected. We previously reported substantial differences in WF metabolism among ...
This experiment was conducted to establish a system for detecting trace cobalt ions in water and plant tissues using a voltammetric in vivo sensor. Cyclic and stripping voltammetry was devised from hand-made, macro-type implantable three-electrode systems. ...
We investigated the endocrine‐disrupting effects of PFOS using a combination of in vitro and in vivo assays. Reporter gene assays were used to detect receptor‐mediated (anti‐)estrogenic, (anti‐)androgenic, and (anti‐)thyroid hormone activities. ...
Nanoconjugates have matured from simple devices to multifunctional, biodegradable, non–toxic and non–immunogenic constructs, capable of delivering synergistically functioning drugs in vivo. The present study evaluates the efficacy of drug polymer self folding nano–conjugates of pectin–cisplatin to enhance blood circulating levels of cisplatin. ...
In this paper, we present data from exposed human patients, showing that a simple assay using blood can demonstrate variation in the extent and type of non-targeted effects and that exposure to radiation can modulate the subsequent non-targeted response to a later dose. ...