Inflammatory Bowel Disease Articles & Analysis
24 articles found
Moreover, TREM1 activation augments the oxidative burst and microbicidal activity of phagocytes, illustrating its role in host defense mechanisms. Implications in Disease The dysregulation of TREM1 has been implicated in an array of inflammatory and infectious diseases. ...
These results suggest that oral delivery of mRNA-loaded LNP is a viable strategy for treating gastrointestinal diseases by reestablishing the intestinal microenvironment. 2) Inhalation is also a preferred route of administration. ...
Their immune-modulatory abilities make them a sought-after tool in treating autoimmune diseases, while their differentiation potential is harnessed for tissue repair and regeneration. In a clinical context, MSCs are instrumental in treating osteoarthritis, inflammatory bowel disease, graft-versus-host disease, ...
Extracellular adenosine provides protective effects by mitigating inflammation in conditions such as myocardial injury[7], acute lung injury[8], intestinal ischemia-reperfusion injury[9], and inflammatory bowel disease[10]. In the context of cancer, tumors harness extracellular adenosine to shield cancer cells. ...
It usually binds to its inhibitory protein in a non-activated state in the form of P50-P65 dimer. Many inflammatory responses are strongly associated with NF-κB activation. By combining CPP (8K, octa-yLysine) with NF-κB essential regulator binding domain (NBD), Dave et al. treated mice with inflammatory bowel disease ...
These signaling molecules form intricate networks that contribute to immune responses, inflammatory reactions, cell proliferation, and growth. Cytokine Dysregulation in Systemic Immune Diseases The perturbation of immune tolerance leads to disruption in cytokine homeostasis. ...
The binding of IL-36 Ra to IL-1R6 does not lead to the recruitment of IL-1RAcP. Therefore, the pro-inflammatory cascade reaction is not initiated, realizing the anti-inflammatory characteristics of IL-36 Ra. ...
Inflammation is a series of complex response events produced by the host system to pathogen infection and various tissue injuries. When the inflammatory response continues, it enters the stage of "uncontrollable inflammation", which plays an important role in the occurrence and development of complex diseases such as tumors. ...
Application in the diagnosis and prognosis determination of small intestinal clonorchiasis Small bowel clonorchiasis is an inflammatory disease of the intestine of unknown origin. It and chronic non-specific ulcerative colitis are collectively known as inflammatory bowel disease (IBD). The ...
It’s reported that persistent activation of NF-κB can lead to chronic inflammation, such as rheumatoid arthritis, Parkinson's disease, and inflammatory bowel disease. However, NF-κB activation requires interactions with NF-κB essential modulators and kinase complexes. A test was carried out by combining ...
Immune-related enterocolitis (irEC) is an inflammatory bowel disease that is the most common serious complication. ...
What are these diseases? Rare diseases are those that occur infrequently in the general population. ...
Furthermore, TNF-a represents the most validated clinical target for ulcerative colitis (UC) and inflammatory bowel diseases (IBD) with multiple emerging neutralizing/inflammation-reducing therapeutics targeting this cytokine for inactivation. TNF-a activation of intestinal epithelia can disrupt the intestinal barrier via mechanisms including ...
Observational study with retrospective and prospective data collection, for total of 24 months. This is an IBD technology study investigating quantitative metrics for endoscopy, histology and radiology for improved diagnosis and assessment of ...
The authors report that STAT1KO mice spontaneously develop inflammatory diseases characterized by bone marrow hyperplasia and splenic accumulation of hematopoietic stem cells. In addition, these animals developed inflammatory bowel disease. Analysis of intestinal bacteria revealed severe dysbiosis in the absence ...
Their relative population size is dynamic, depending on the state of the body (inflammatory bowel disease, diabetes, etc.). The intestinal microecosystem is rich in various compounds secreted by the host, such as glycoproteins, saliva, gastric juice, bile salts and mucus, and consumes about 1.5 kg of amino acids, short-chain fatty acids and ...
Key questions in intestinal health and disease require an understanding of how changes in intestinal niches cause, perpetuate, or allow recovery from injury. ...
Intestinal inflammatory diseases are highly complex, which has thus far prevented development of an effective in vitro disease model. With access to a donor-derived cell biobank and the ability to recapitulate region-specific environments of the intestine, Altis Biosystems is working toward the development of an in vitro RepliGut® model to ...
Abstract Gut microbiota play a major role in host physiology and immunity. Inflammatory bowel diseases (IBDs), the important immune-related diseases, can occur through immune system malfunction originating due to dysregulation of the gut microbiota. ...
The microbiome has been shown to play roles in many different disease processes and is implicated in many more, from infectious and gastrointestinal diseases to autoimmune and neurological disorders. ...