Inflammatory Diseases Articles & Analysis: Older
47 articles found
Antibody drugs are a kind of drugs that treat diseases through artificially synthesized antibodies, achieving therapeutic purposes by specifically binding with target molecules. ...
Antibody drugs are a type of drugs that treat diseases through artificially synthesized antibodies, which bind specifically to target molecules for therapeutic purposes. ...
It is involved in the breakdown of invading microorganisms and cellular debris during inflammatory responses. By degrading harmful entities, elastase helps in modulating immune responses and tissue repair. ...
Autophagy has also been implicated in pathological conditions including neurodegenerative diseases, cancer, and inflammatory diseases. Modulation of autophagy has become a potential therapeutic target in human diseases. ...
This test is commonly used to monitor a patient's immune response to biological agents or other drugs, especially in the treatment of chronic diseases such as autoimmune diseases, certain cancers, and inflammatory diseases. ...
In post-translational modification (PTM) of proteins, ubiquitination is considered one of the most critical processes in regulating cellular functions and various diseases. The identification of ubiquitination sites becomes very crucial for understanding the mechanisms of ubiquitination-related biological processes. ...
The versatility of nanobodies has led to the development of a wide range of nanobody-based drug delivery systems for various diseases, including cancer, infectious diseases, and inflammatory disorders. For example, nanobodies have been used to deliver anti-inflammatory drugs to inflamed tissues, resulting in reduced inflammation ...
Th1 cells suppress B-cell function and mediate cellular immunity by secreting inflammatory cytokines such as interleukin (IL) and interferon (IFN), and enhance anti-infective immunity by phagocytes. ...
The future of antibody-drug conjugate development appears to be very promising, with prospective improvements and advancements in multiple areas: Improved target selection: With the advancement in genomics and proteomics, the future may bring a better understanding of disease biology, leading to the identification of more disease-specific targets for ADCs. ...
Moreover, TREM1 activation augments the oxidative burst and microbicidal activity of phagocytes, illustrating its role in host defense mechanisms. Implications in Disease The dysregulation of TREM1 has been implicated in an array of inflammatory and infectious diseases. ...
Candidate drugs like ARV110 and ARV-471 have entered Phase I/II clinical trials, indicating the potential of PROTACs in the treatment of cancer and other diseases. The high selectivity, resistance-overcoming capabilities, and ability to target previously undruggable proteins make PROTACs effective in various diseases, including neurological disorders, ...
Diagnostic potential: Fluorescent liposomes can be loaded with imaging agents for specific diseases, potentially enabling non-invasive diagnosis and monitoring of various conditions. ...
Their immune-modulatory abilities make them a sought-after tool in treating autoimmune diseases, while their differentiation potential is harnessed for tissue repair and regeneration. In a clinical context, MSCs are instrumental in treating osteoarthritis, inflammatory bowel disease, graft-versus-host disease, myocardial ...
It usually binds to its inhibitory protein in a non-activated state in the form of P50-P65 dimer. Many inflammatory responses are strongly associated with NF-κB activation. By combining CPP (8K, octa-yLysine) with NF-κB essential regulator binding domain (NBD), Dave et al. treated mice with inflammatory bowel disease by ...
Furthermore, MMP-3 is a reliable biomarker for assessing disease activity, imaging monitoring, predicting disease outcomes, and treatment response in rheumatoid arthritis [4]. MMP-3 and Ankylosing Spondylitis (AS) AS is a chronic inflammatory disease that primarily affects the spine and sacroiliac joints. ...
Autoimmune disease target - IL-17 Family IL-17 plays an important role in promoting autoimmune diseases such as psoriasis, psoriatic arthritis, and ankylosing spondylitis (AS). ...
The binding of IL-36 Ra to IL-1R6 does not lead to the recruitment of IL-1RAcP. Therefore, the pro-inflammatory cascade reaction is not initiated, realizing the anti-inflammatory characteristics of IL-36 Ra. ...
Deficiencies in the IL-2R alpha and IL-2R gamma subunits disrupt this IL-2-mediated feedback regulation, ultimately leading to the occurrence of autoimmune/inflammatory diseases. IL-2 regulates innate immune cells In humans, monocytes express IL-2R under the stimulation of IFN-γ, but only activated monocytes can bind with IL-2. During the ...
Inflammation is a series of complex response events produced by the host system to pathogen infection and various tissue injuries. When the inflammatory response continues, it enters the stage of "uncontrollable inflammation", which plays an important role in the occurrence and development of complex diseases such as tumors. ...
In recent years, enzymes have been widely used in disease diagnosis, providing a quick and accurate way to detect and monitor diseases. Enzymes for disease diagnosis can be divided into two categories: those that are produced by the body in response to disease and those that are specific to the disease itself. ...