Intestinal Inflammation Articles & Analysis
6 articles found
Seminal research further revealed that A2AR signaling plays an essential role in quelling tissue-damaging inflammation[6]. Extracellular adenosine provides protective effects by mitigating inflammation in conditions such as myocardial injury[7], acute lung injury[8], intestinal ischemia-reperfusion injury[9], and inflammatory bowel disease[10]. ...
Li et al constructed a novel siRNA delivery system sTOLP(loaded with siRNAOA-R8 / TF-modified LNP) for cell penetrating peptioyl-octadecarginine (OA-R8) transferrin (Tf)-modified multifunctional lipid nanoparticles (LNP). siRNA encapsulated in sTOLP showed strong tumor inhibition (61.7%) and was preferentially absorbed by hepatocytes and tumor cells in HepG2-containing mice without inducing ...
Inflammatory effectors are key cytokines driving major clinical symptoms, like INF-γ inducing fever and hematopoiesis, TNF-α causing fever and depression, and IL-6 contributing to fever, acute kidney injury, and NK cell dysfunction. Inflammation initiation factors involve virus recognition by macrophage pattern receptors, triggering inflammasome assembly and the ...
In addition, drug activity was also observed in paclitaxel-resistant cells. 3. Targeted Treatment of Inflammation The nuclear transcription factor kappaB (NF-κB) is a vital transcriptional regulator in cells. ...
Tumor Necrosis Factor Alpha (TNF-a) is a potent cytokine that is over-expressed by cells during chronic intestinal inflammation. Furthermore, TNF-a represents the most validated clinical target for ulcerative colitis (UC) and inflammatory bowel diseases (IBD) with multiple emerging neutralizing/inflammation-reducing therapeutics targeting this ...
” Limitations of Animal Models The obvious approach to study intestinal inflammation is to make an animal model; however, to generate animal models of intestinal diseases involving inflammation, it is first necessary to induce damage in a manner similar to disease initiation. ...