Killer Cells Articles & Analysis
25 articles found
They are synthesized and secreted by a range of immune cells, including monocytes, macrophages, T cells, B cells, and natural killer (NK) cells, as well as certain non-immune cells like endothelial cells, epidermal cells, and fibroblasts. Cytokines are produced ...
In addition, the prolonged interaction interval between antigen and presenting cells also enhances the induced immune response. Recruitment of Immune Cells When injected intramuscularly, the aluminum adjuvant stimulates the body’s innate immunity. The major players in innate immunity include dendritic cells, macrophages, monocytes, ...
This cutting-edge technology holds great potential in treating diseases through targeted drug delivery. CAR-T/CAR-NK Cells Development for Drug Delivery Systems As a groundbreaking advancement in immunotherapy, CAR-T (Chimeric Antigen Receptor T-cell) and CAR-NK (Chimeric Antigen Receptor Natural Killer) cells have shown ...
It achieves this by binding to the adenosine A2A receptor (ADORA2A), which is expressed by various immune cells like T cells, natural killer (NK) cells, and dendritic cells (DCs). ...
They facilitate the recognition and binding of immune cells, such as T cells, B cells, and antigen-presenting cells, during immune responses. ...
Researchers state that enoblituzumab, as a new treatment approach, primarily works by relieving the inhibition of the immune system's recognition and elimination of cancer cells by B7-H3. It triggers the physiological process of antibody-dependent cell cytotoxicity (ADCC), activating cytotoxic immune cells such as macrophages and natural ...
IL-17D IL-17D is expressed in many cells and organs, but its expression in immune cells such as lymphocytes and monocytes is weak. IL-17D induces endothelial cells to produce IL-6, IL-8, and GM-CSF. It also has an inhibitory effect on hematopoiesis of bone marrow precursor cells. Other studies suggest that IL-17D is associated ...
For example, matrix-targeting ADC drugs have the potential to cause cancer cell death by reducing the concentration of growth factors produced by matrix-resident cells. ...
Abstract Natural killer (NK) cells are emerging as a new tool for cell therapy of cancer. However, some cancer subtypes are relatively resistant to NK cell cytotoxicity. Expression of anti-CD19 chimeric signaling receptors can enhance NK-cell reactivity against CD19+ leukemia and lymphoma ...
In hematological malignancies, complete response rates to CAR-T cells can exceed 80%. These responses are often durable in nature and have attracted considerable excitement and investment in the development of cell therapies for an expanded range of indications, particularly in solid tumors. ...
Cytokines are small soluble proteins that are secreted by immune cells and tissue cells to play a regulatory role between cells, including interferon (IFN), interleukin (IL), chemokines, colony-stimulating factors (CSF), tumor necrosis factors (TNF) and so on. ...
T cells can be separated into two subpopulations based on the expression of T-cell receptors (TCRs). αβ T cells, expressing expressing αβ TCR, recognize peptide antigens, such as those expressed by cancer cells. αβ T cells are the effector cells of adaptive immunity, which exert cytotoxicity in a ...
For example, IL-2 is produced by activated T cells and can enhance the growth and proliferation of T cells themselves; IL-12 can be produced by dendritic cells, B cells, and monocytes-macrophages and can induce the directed differentiation of T cells into type 1 helper T cells. ...
CD94 (Group of Differentiation 94), also known as Killer cell lectin-like receptor subfamily D member 1 (KLRD1), is expressed on the surface of natural killer cells in the innate immune system. ...
Spacing between posts, along with a brief electric field, allows for T cells to flow through without significant physical deformation or perturbation of the cell state. The vortices created by the posts apply hydrodynamic forces to the cell membrane which cause temporary pores allowing for the diffusion and electrophoretic transfer of constructs ...
Bispecific antibodies that target tumors by engaging innate-like T cell subsets with inherent antitumor activity Bispecific antibodies that target tumors by engaging innate-like T cell subsets with inherent antitumor activity CD1d can be expressed by several hematologic malignancies Bispecific Vγ9Vδ2-T cell engager Unique ...
Killer T-Cells are responsible for destroying bacteria and viruses in healthy people, but for those with type 1 diabetes they attack beta cells. Tregs (regulatory T-Cells) usually keep the killer T-Cells at bay by “turning them off”, but become outnumbered for people with type 1. ...
The resulting therapeutics have been shown to produce remission rates exceeding 80% in patients with CD19+ B-cell lymphoma, making them nothing short of remarkable [1]. Unfortunately, CAR-T cells seem to have several caveats, which have limited their translation to other types of cancer [2]. ...
Abstract Viral infection of the liver is a major risk factor for hepatocellular carcinoma (HCC). Natural killer (NK) cells recognize virally infected and oncogenically transformed cells, suggesting a therapeutic role for NK-cell infusions in HCC. ...
San Francisco, CA –Aelan Cell Technologies, with an international research team, today released a study that reveals that age is a key determining factor in the efficacy of cell-based or pharmacological treatments. ...