liver cell Articles
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Identification and analysis of epitope-based malarial vaccine targets using computational biology
Malaria is a vector-borne infectious disease caused by protozoan parasite of the genus Plasmodium. The malaria vaccine which has been studied is designed to induce immunity to the sporozoite and to kill sporozoite-infected liver cells. A combination of bioinformatics approach and computational tools are used to screen and select antigen sequences as potential T-cell epitopes of supertype human ...
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Modeling NAFLD using 3D bioprinted human liver tissue
Publication Summary: Nonalcoholic fatty liver disease (NAFLD) is a chronic condition that originates as lipid accumulation within hepatocytes (steatosis) and progresses into nonalcoholic steatohepatitis (NASH), characterized by lipid accumulation, inflammation, oxidative stress, and fibrosis. NAFLD is now recognized as the most common cause of chronic liver disease, with a prevalence of 25% ...
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Modeling NAFLD using 3D bioprinted human liver tissue
Publication Summary: Nonalcoholic fatty liver disease (NAFLD) is a chronic condition that originates as lipid accumulation within hepatocytes (steatosis) and progresses into nonalcoholic steatohepatitis (NASH), characterized by lipid accumulation, inflammation, oxidative stress, and fibrosis. NAFLD is now recognized as the most common cause of chronic liver disease in the western world, with an ...
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The Pivotal Glutathione Reductase
Glutathione is a tripeptide containing sulfhydryl groups combined with glutamic acid, cysteine and glycine. Glutathione has two forms, reduced (G-SH) and oxidized (G-S-S-G), and reduced glutathione accounts for the vast majority under physiological conditions. Glutathione reductase catalyzes the interconversion between the two types. The coenzyme of this enzyme is NADPH provided by the ...
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Detection of biomarker p53 mutated gene by a silicon nanowire nanosensor
Among biosensors of various types, the silicon nanowire field–effect transistor (SiNW–FET) is believed to be the most sensitive and powerful device for bio–applications. In fact, these devices have demonstrated the ability to detect a variety of analyses such as particular DNA sequences, cancer biomarkers and larger entities such as viruses. The principle of sensing is based on the variation of ...
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Pooled Human Cryopreserved Hepatocytes
Hepatocytes are the chief functional cells of the liver, responsible for the selective uptake, metabolism and excretion of most drugs. Cells for use in plate cultures or suspension assays represent a key tool for predicting properties such as hepatotoxicity, metabolism, and potential drug-drug interactions. Since these cells mimic the properties of the liver, researchers can evaluate the ...
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Why Liver Health is so important? (Or, did you know that in the U.S. 100 million people may have fatty livers?)
Let's face it; the liver is the primary organ in the body that often gets overlooked when it comes to health. According to Traditional Chinese Medicine, the liver is the organ responsible for the smooth flow of emotions, as well as Qi (Energy) and blood. It is the organ that is most affected by excess stress or emotions.Ii] The liver is responsible for numerous functions in the body. Its primary ...
By Algatech
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Avail The Best Treatment of Liver Transplant in Delhi
The liver is one of the most vital organs of the body. It means one cannot live without the proper functioning of the liver. It performs many critical functions of the body which include enhancing metabolism of the body, removing degrading products, and synthesis of enzymes and proteins. The main function of the liver is that the blood enters the liver through two chains – one is the ...
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Acute and subacute oral toxicity of polychlorinated diphenyl sulfides in mice: Determining LD50 and assessing the status of hepatic oxidative stress
Polychlorinated diphenyl sulfides (PCDPSs), a series of dioxin‐like compounds, have been detected in various environmental samples. However, information on the toxicity of these compounds is limited. In the present study, the toxic effects of PCDPSs were assessed after acute and subacute exposure in mice. Relationships between acute toxicity, number, and position of substituted Cl atoms were ...
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Bioartificial liver: review of science requirements and technology
Social development in health services is concerned as a global issue. More than nine million people die due to internal organ failure and one percent of this number is due to liver disease. In 1990, more than 27,000 deaths in the USA were caused by liver failure. From the numerous reviews on liver failure and associated support therapies, there is increasing interest in this field throughout the ...
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Research Progress of Tetrahydrocurcumin
Tetrahydrocurcumin (THC), as the most active and main metabolite produced in the metabolism of curcumin in vivo, can be isolated from the cytoplasm of the small intestine and liver after curcumin administration in human or mouse. Tetrahydrocurcumin can effectively inhibit tyrosinase, inhibit the generation of Oxygen Free Radicals and scavenge the formed free radicals. It has obvious antioxidant ...
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Expanding Our Commitment to Rare Disease Therapeutics
Each year, the last day of February serves as a reminder to pause and reflect on the challenges and unique needs of patients and families living with rare diseases. It is an opportunity for all members of the patient, medical, and scientific communities to shine a light on the urgent need to improve the care and support for those impacted by such conditions. At Moderna, we are working to ...
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Catalase, a Common Antioxidant Enzyme
Catalase is an antioxidant enzyme commonly found in almost all living organisms, mainly in chloroplasts, mitochondria, endoplasmic reticulum of plants, liver and red blood cells of animals. It is the marker enzyme of the peroxisome, accounting for about 40% of the total peroxisomal enzymes. Catalase is a homotetramer composed of four polypeptide chains, each containing more than 500 amino acid ...
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Long-term performance of implanted bioprinted human liver tissue in a mouse model of human alpha-1 antitrypsin deficiency
Publication Summary: Conventional cell therapy and tissue engineering approaches to treating liver diseases and injury are limited by low cell retention, poor engraftment, poor graft durability and complications including portal hypertension. Integration of next generation technologies such as 3D bioprinting is an essential step towards the clinical success of these promising approaches and has ...
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Understanding Induced Pluripotent Stem Cell Differentiation and the Role of iPSC Differentiation Kits in Biological Research
Pluripotent stem cells — cells with the ability to differentiate into nearly any cell type in the body, constituting a significant potential for regenerative medicine. Among these, induced Pluripotent Stem Cells (iPSCs), in particular, have garnered substantial interest from the scientific community due to their ability to be produced from adult cells, eliminating the ethical quandaries ...
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Advances in siRNA Drug Research
siRNA, with a molecular weight of about 13 kDa, recruits the RNA-induced silencing complex (RISC) to mRNA through base pairing, thereby inhibiting protein translation. The mRNA is targeted for cleavage through the catalysis of the RISC protein Ago2, a member of the Argonaute family. In addition, other Ago proteins (Ago1, Ago3, and Ago4) catalyze endonuclease-mediated degradation of non-specific ...
By BOC Sciences
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Nonalcoholic Fatty Liver and How Fucoxanthin Might Help
Many may not have heard of nonalcoholic fatty liver (NAFL) yet it is a very common condition. If NAFL is not addressed, it can progress to a serious condition known as Nonalcoholic fatty liver disease (NAFLD) Non-alcoholic fatty liver is the buildup of extra fat in liver cells that is not caused by alcohol. It is normal for the liver to contain some fat. However, if more than 5% -10% percent of ...
By Algatech
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Basic Information and Application of Alcohol Dehydrogenase
Alcohol dehydrogenase is abundant in human and animal liver, plant and microbial cells. It is a zinc-containing metalloenzyme with broad substrate specificity. Alcohol dehydrogenase can use nicotinamide adenine dinucleotide (NAD) as a coenzyme to catalyze the reversible reaction between primary alcohols and aldehydes: CH3CH2OH+ NAD+→ CH3CHO +NADH+ H+. In humans and mammals, alcohol ...
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Development of mRNA-Directed Delivery - LNP Delivery System
During the COVID-19 pandemic, the success of mRNA vaccines has greatly propelled the development of mRNA therapeutics. mRNA is a negatively charged nucleic acid that serves as a template for protein synthesis in ribosomes. Despite its utility, the instability of mRNA necessitates appropriate carriers for in vivo delivery. Currently, lipid nanoparticles (LNPs) are the most mature approach for ...
By BOC Sciences
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Introduction of Chitosan as Nano-drug Delivery Carrier
Chitin is the second largest natural polymer after cellulose, and it exists widely in nature, such as shells of crustaceans such as shrimps, crabs, insects, and cell walls of fungi. Although chitin has good biocompatibility and biodegradability, its poor solubility limits its practicality in the field of biomedicine. The product of chitin deacetylation is chitosan. Chitosan is structurally ...
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