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Liver Cell Articles & Analysis

22 articles found

Preclinical Models of Non-Alcoholic Fatty Liver Disease

Preclinical Models of Non-Alcoholic Fatty Liver Disease

Non-alcoholic fatty liver disease (NAFLD) has emerged as a significant public health concern, associated with obesity, insulin resistance, and a spectrum of metabolic disorders. ...

ByCreative Bioarray


Pooled Human Cryopreserved Hepatocytes

Pooled Human Cryopreserved Hepatocytes

Hepatocytes are the chief functional cells of the liver, responsible for the selective uptake, metabolism and excretion of most drugs. ...

ByCreative Bioarray


Development of mRNA-Directed Delivery - LNP Delivery System

Development of mRNA-Directed Delivery - LNP Delivery System

Subsequently, apolipoprotein E (ApoE) binds with the LNP to form a corona, which is recognized by low-density lipoprotein receptors on liver cells and promotes LNP internalization. Many studies have followed the prescription of Onpattro to prepare liver-targeted LNPs. ...

ByBOC Sciences


Advances in siRNA Drug Research

Advances in siRNA Drug Research

It has good biofilm property and containment and can promote cell uptake and endosomal escape while avoiding nuclease degradation. The positive charge carried by cationic liposomes can neutralize the negative charge carried by siRNA to form a tightly structured complex that greatly extends the cycle time and facilitates the delivery of siRNA. Peptide-siRNA Conjugates ...

ByBOC Sciences


Understanding Induced Pluripotent Stem Cell Differentiation and the Role of iPSC Differentiation Kits in Biological Research

Understanding Induced Pluripotent Stem Cell Differentiation and the Role of iPSC Differentiation Kits in Biological Research

Pluripotent stem cells — cells with the ability to differentiate into nearly any cell type in the body, constituting a significant potential for regenerative medicine. Among these, induced Pluripotent Stem Cells (iPSCs), in particular, have garnered substantial interest from the scientific community due to their ability to ...

ByCreative Bioarray


Research Progress of Tetrahydrocurcumin

Research Progress of Tetrahydrocurcumin

The results showed that tetrahydrocurcumin could significantly reduce the blood glucose of diabetic rats and improve the plasma insulin level, indicating that tetrahydrocurcumin has a good hypoglycemic effect on type 2 diabetes. 2.Anti-oxidative Stress Effect Murugan P et al. used niacinamide to induce diabetic rats, and the results showed that tetrahydrocurcumin could significantly improve the ...

ByHunan Huateng Pharmaceutical Co. Ltd.


Introduction of Chitosan as Nano-drug Delivery Carrier

Introduction of Chitosan as Nano-drug Delivery Carrier

By comparing the toxicity of chitosan oligosaccharides with different molecular weights and different degrees of deacetylation to prostate cancer cells PC3, lung cancer cells A549 and liver cancer cells HepG2, the researchers found that chitosan with low molecular weight and low degree of deacetylation has Better anti-tumor ...

ByCD Bioparticles


Catalase, a Common Antioxidant Enzyme

Catalase, a Common Antioxidant Enzyme

Catalase is an antioxidant enzyme commonly found in almost all living organisms, mainly in chloroplasts, mitochondria, endoplasmic reticulum of plants, liver and red blood cells of animals. It is the marker enzyme of the peroxisome, accounting for about 40% of the total peroxisomal enzymes. ...

ByCreative Enzymes


The Pivotal Glutathione Reductase

The Pivotal Glutathione Reductase

Loss of glutathione reductase makes cells more sensitive to oxidants and antibiotics. For patients with liver damage, the detection of glutathione reductase can enable us to understand whether the function of the body's glutathione antioxidant system is sound. The reduction of glutathione reductase indicates that the detoxification function and antioxidant ...

ByCreative Enzymes


Basic Information and Application of Alcohol Dehydrogenase

Basic Information and Application of Alcohol Dehydrogenase

Alcohol dehydrogenase is abundant in human and animal liver, plant and microbial cells. It is a zinc-containing metalloenzyme with broad substrate specificity. ...

ByCreative Enzymes


Avail The Best Treatment of Liver Transplant in Delhi

Avail The Best Treatment of Liver Transplant in Delhi

The liver is one of the most vital organs of the body. It means one cannot live without the proper functioning of the liver. ...

ByLiver Transplant India


Nonalcoholic Fatty Liver and How Fucoxanthin Might Help

Nonalcoholic Fatty Liver and How Fucoxanthin Might Help

Many may not have heard of nonalcoholic fatty liver (NAFL) yet it is a very common condition. If NAFL is not addressed, it can progress to a serious condition known as Nonalcoholic fatty liver disease (NAFLD) Non-alcoholic fatty liver is the buildup of extra fat in liver cells that is not caused by alcohol. It is ...

ByAlgatech


Why Liver Health is so important? (Or, did you know that in the U.S. 100 million people may have fatty livers?)

Why Liver Health is so important? (Or, did you know that in the U.S. 100 million people may have fatty livers?)

Studies shows that silymarin may help with the regeneration of liver cells, decrease inflammation and protect liver cells from damage in an antioxidant type mannerriiil « Read: Study shows FucoVital to be more effective than silvmarin in preventing harmful fat accumulation in liver cells ...

ByAlgatech


Modeling NAFLD using 3D bioprinted human liver tissue

Modeling NAFLD using 3D bioprinted human liver tissue

NAFLD is now recognized as the most common cause of chronic liver disease in the western world, with an estimated prevalence of 25% worldwide, and is projected to become the leading indication for liver transplant by 2025. ...

ByOrganovo Holdings Inc.


Expanding Our Commitment to Rare Disease Therapeutics

Expanding Our Commitment to Rare Disease Therapeutics

Rather than replacing proteins or genes, mRNA instructs cells to produce specific proteins. The patient’s cell then becomes the factory that produces the needed protein. ...

ByModerna, Inc.


Modeling NAFLD using 3D bioprinted human liver tissue

Modeling NAFLD using 3D bioprinted human liver tissue

Publication Summary: Nonalcoholic fatty liver disease (NAFLD) is a chronic condition that originates as lipid accumulation within hepatocytes (steatosis) and progresses into nonalcoholic steatohepatitis (NASH), characterized by lipid accumulation, inflammation, oxidative stress, and fibrosis. NAFLD is now recognized as the most common cause of chronic liver ...

ByOrganovo Holdings Inc.


Harmful Effects of Arsenic on Human Health

Harmful Effects of Arsenic on Human Health

Ingestion of this specific type of arsenic can also cause a reduction in blood cell production, liver enlargement, loss of sensation in the limbs, and brain damage. ...

ByChartWater™ - A Chart Industries Company


Harmful Effects of Arsenic on Human Health - Case Study

Harmful Effects of Arsenic on Human Health - Case Study

Ingestion of this specific type of arsenic can also cause a reduction in blood cell production, liver enlargement, loss of sensation in the limbs, and brain damage. ...

ByChartWater™ - A Chart Industries Company


Long-term performance of implanted bioprinted human liver tissue in a mouse model of human alpha-1 antitrypsin deficiency

Long-term performance of implanted bioprinted human liver tissue in a mouse model of human alpha-1 antitrypsin deficiency

Publication Summary: Conventional cell therapy and tissue engineering approaches to treating liver diseases and injury are limited by low cell retention, poor engraftment, poor graft durability and complications including portal hypertension. Integration of next generation technologies such as 3D bioprinting is an essential step towards the ...

ByOrganovo Holdings Inc.


Detection of biomarker p53 mutated gene by a silicon nanowire nanosensor

Detection of biomarker p53 mutated gene by a silicon nanowire nanosensor

In this study, we have used two different processes for surface modification of silicon nanowire. As the DNA of liver cancer cells has mutation at codon 249 which changes one base guanine (G) by base thymine (T), we thus designed 17–mer DNA oligonucleotides, which were used as a receptor to capture the DNA of p53 mutated gene. The fabricated SiNW biosensor could ...

ByInderscience Publishers

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